All Stories

  1. A necroptotic-to-apoptotic signaling axis underlies inflammatory bowel disease

    Article • Science, August 2026, American Association for the Advancement of Science

    Dr Andre L Samson

  2. Author Correction: In situ visualization of endothelial cell-derived extracellular vesicle formation in steady state and malignant conditions

    Article • Nature Communications, October 2025, Springer Science + Business Media

    Dr Andre L Samson

  3. In situ visualization of endothelial cell-derived extracellular vesicle formation in steady state and malignant conditions

    Article • Nature Communications, October 2024, Springer Science + Business Media

    Dr Andre L Samson

  4. Mapping where and when necroptotic cell death occurs in disease

    Article • Cell Death and Differentiation, June 2024, Springer Science + Business Media

    Dr Andre L Samson

  5. MLKL deficiency protects against low-grade, sterile inflammation in aged mice

    Article • Cell Death and Differentiation, February 2023, Springer Science + Business Media

    Dr Andre L Samson

  6. The web of death: the expanding complexity of necroptotic signaling

    Article • Trends in Cell Biology, February 2023, Elsevier

    Dr Andre L Samson

  7. Development of a carotid artery thrombolysis stroke model in mice

    Article • Blood Advances, September 2022, American Society of Hematology

    Dr Andre L Samson

  8. A common humanMLKLpolymorphism confers resistance to negative regulation by phosphorylation

    Article • September 2022, Cold Spring Harbor Laboratory Press

    Dr Andre L Samson

  9. Endothelial Caspase-8 prevents fatal necroptotic hemorrhage caused by commensal bacteria

    Article • Cell Death and Differentiation, July 2022, Springer Science + Business Media

    Dr Andre L Samson

  10. Ubiquitylation of RIPK3 beyond-the-RHIM can limit RIPK3 activity and cell death

    Article • iScience, July 2022, Elsevier

    Dr Andre L Samson

  11. Human RIPK3 C-lobe phosphorylation is essential for necroptotic signaling

    Article • Cell Death and Disease, June 2022, Springer Science + Business Media

    Dr Andre L Samson

  12. Tankyrase-mediated ADP-ribosylation is a regulator of TNF-induced death

    Article • Science Advances, May 2022, American Association for the Advancement of Science

    Dr Andre L Samson

  13. The Lck inhibitor, AMG-47a, blocks necroptosis and implicates RIPK1 in signalling downstream of MLKL

    Article • Cell Death and Disease, April 2022, Springer Science + Business Media

    Dr Andre L Samson

  14. Membrane permeabilization is mediated by distinct epitopes in mouse and human orthologs of the necroptosis effector, MLKL

    Article • Cell Death and Differentiation, March 2022, Springer Science + Business Media

    Dr Andre L Samson

  15. Ferroptosis mediates selective motor neuron death in amyotrophic lateral sclerosis

    Article • Cell Death and Differentiation, December 2021, Springer Science + Business Media

    Dr Andre L Samson

  16. Membrane permeabilization is mediated by distinct epitopes in mouse and human orthologs of the necroptosis effector, MLKL

    Article • May 2021, Cold Spring Harbor Laboratory Press

    Dr Andre L Samson

  17. Conformational interconversion of MLKL and disengagement from RIPK3 precede cell death by necroptosis

    Article • Nature Communications, April 2021, Springer Science + Business Media

    Dr Andre L Samson

  18. A toolbox for imaging RIPK1, RIPK3, and MLKL in mouse and human cells

    Article • Cell Death and Differentiation, February 2021, Springer Science + Business Media

    Dr Andre L Samson

  19. Location, location, location: A compartmentalized view of TNF-induced necroptotic signaling

    Article • Science Signaling, February 2021, American Association for the Advancement of Science

    Dr Andre L Samson

  20. Necroptosis is dispensable for the development of inflammation-associated or sporadic colon cancer in mice

    Article • Cell Death and Differentiation, November 2020, Springer Science + Business Media

    Dr Andre L Samson

  21. A toolbox for imaging RIPK1, RIPK3 and MLKL in mouse and human cells

    Article • October 2020, Cold Spring Harbor Laboratory Press

    Dr Andre L Samson

  22. MLKL trafficking and accumulation at the plasma membrane control the kinetics and threshold for necroptosis

    Article • Nature Communications, June 2020, Springer Science + Business Media

    Dr Andre L Samson

  23. Identification of MLKL membrane translocation as a checkpoint in necroptotic cell death using Monobodies

    Article • Proceedings of the National Academy of Sciences, March 2020, Proceedings of the National Academy of Sciences

    Dr Andre L Samson

  24. Necroptosis is dispensable for motor neuron degeneration in a mouse model of ALS

    Article • Cell Death and Differentiation, November 2019, Springer Science + Business Media

    Dr Andre L Samson

  25. VDAC2 enables BAX to mediate apoptosis and limit tumor development

    Article • Nature Communications, November 2018, Springer Science + Business Media

    Dr Andre L Samson, Andrew Morokoff

  26. Endogenous fibrinolysis facilitates clot retraction in vivo

    Article • Blood, October 2017, American Society of Hematology

    Dr Andre L Samson

  27. Protein aggregation or liberation during cell necrosis

    Article • Open Biology, November 2016, Royal Society Publishing

    Dr Andre L Samson, Professor Robert L Medcalf

  28. Passenger mutations and aberrant gene expression in congenic tissue plasminogen activator-deficient mouse strains

    Article • Journal of Thrombosis and Haemostasis, June 2016, Wiley

    Dr Andre L Samson

  29. MouseMove: an open source program for semi-automated analysis of movement and cognitive testing in rodents

    Article • Scientific Reports, November 2015, Nature

    Dr Andre L Samson

  30. Dendritic Cell-Mediated Phagocytosis but Not Immune Activation Is Enhanced by Plasmin

    Article • PLOS One, July 2015, PLOS

    Dr Andre L Samson

  31. Activated platelets rescue apoptotic cells via paracrine activation of EGFR and DNA-dependent protein kinase

    Article • Cell Death and Disease, September 2014, Nature

    Dr Andre L Samson

  32. Oxidation of an Exposed Methionine Instigates the Aggregation of Glyceraldehyde-3-phosphate Dehydrogenase

    Article • Journal of Biological Chemistry, August 2014, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Andre L Samson

  33. Tissue-type plasminogen activator is an extracellular mediator of Purkinje cell damage and altered gait

    Article • Experimental Neurology, November 2013, Elsevier

    Dr Andre L Samson

  34. Nucleocytoplasmic Coagulation: An Injury-Induced Aggregation Event that Disulfide Crosslinks Proteins and Facilitates Their Removal by Plasmin

    Article • Cell Reports, October 2012, Elsevier

    Dr Andre L Samson

  35. The tissue-type plasminogen activator-plasminogen activator inhibitor 1 complex promotes neurovascular injury in brain trauma: evidence from mice and humans

    Article • Brain, July 2012, Oxford University Press (OUP)

    Dr Andre L Samson

  36. Neovascularization Is Attenuated With Aldosterone Synthase Inhibition in Rats With Retinopathy

    Article • Hypertension, January 2012, Wolters Kluwer Health

    Dr Andre L Samson

  37. Compartment- and context-specific changes in tissue-type plasminogen activator (tPA) activity following brain injury and pharmacological stimulation

    Article • Laboratory Investigation, April 2011, Nature

    Dr Andre L Samson

  38. Thrombin-induced activation of astrocytes in mixed rat hippocampal cultures is inhibited by soluble thrombomodulin

    Article • Brain Research, March 2011, Elsevier

    Dr Andre L Samson

  39. Novel Role of Platelets in Mediating Inflammatory Responses and Ventricular Rupture or Remodeling Following Myocardial Infarction

    Article • Arteriosclerosis Thrombosis and Vascular Biology, January 2011, Wolters Kluwer Health

    Dr Andre L Samson

  40. A nonfibrin macromolecular cofactor for tPA-mediated plasmin generation following cellular injury

    Article • Blood, July 2009, American Society of Hematology

    Dr Andre L Samson

  41. Low molecular weight contaminants in commercial preparations of plasmin and t-PA activate neurons

    Article • Journal of Thrombosis and Haemostasis, December 2008, Wiley

    Dr Andre L Samson

  42. Tissue-type plasminogen activator requires a co-receptor to enhance NMDA receptor function

    Article • Journal of Neurochemistry, October 2008, Wiley

    Dr Andre L Samson

  43. Two conserved regions within the tissue-type plasminogen activator gene promoter mediate regulation by brain-derived neurotrophic factor

    Article • European Journal of Biochemistry, April 2007, Wiley

    Dr Andre L Samson

  44. Oncostatin M is a neuroprotective cytokine that inhibits excitotoxic injury in vitro and in vivo

    Article • The FASEB Journal, November 2006, Federation of American Societies For Experimental Biology (FASEB)

    Dr Andre L Samson

  45. Tissue-Type Plasminogen Activator: A Multifaceted Modulator of Neurotransmission and Synaptic Plasticity

    Article • Neuron, June 2006, Elsevier

    Professor Robert L Medcalf, Dr Andre L Samson

  46. Vampire Bat Salivary Plasminogen Activator (Desmoteplase): A Unique Fibrinolytic Enzyme That Does Not Promote Neurodegeneration

    Article • Stroke, January 2003, Wolters Kluwer Health

    Dr Andre L Samson