All Stories

  1. Experimental and mathematical models reveal that AMPK modulates circadian clock gene expression and period through NAD+-dependent regulation of Bmal1

    Article • September 2026, openRxiv

    Dr. Alexandre Berthier

  2. The Biological Clock Controls Liver Scarring

    Article • Proceedings of the National Academy of Sciences, July 2026, Proceedings of the National Academy of Sciences

    Dr. Alexandre Berthier, Manuel Johanns

  3. Derepression of the epithelial transcription factor GRHL2 promotes direct hepatocyte-to-cholangiocyte transdifferentiation

    Article • PLoS Biology, December 2025, PLOS

    Dr. Alexandre Berthier

  4. The Circadian Clock Controls Hepatic Stellate Cell Activation in Liver Fibrosis via a BMAL1/CK1ε/REV-ERBα/Transgelin Signaling Pathway

    Article • September 2025, openRxiv

    Dr. Alexandre Berthier

  5. Unveiling the molecular legacy of transient insulin resistance: Implications for hepatic metabolic adaptability

    Article • Journal of Hepatology, August 2025, Elsevier

    Dr. Alexandre Berthier

  6. O-GlcNAcylation controls pro-fibrotic transcriptional regulatory signaling in myofibroblasts

    Article • Cell Death and Disease, June 2024, Springer Science + Business Media

    Dr. Alexandre Berthier

  7. The Molecular Circadian Clock Is a Target of Anti-cancer Translation Inhibitors

    Article • Journal of Biological Rhythms, October 2023, SAGE Publications

    Dr. Alexandre Berthier

  8. An extended transcription factor regulatory network controls hepatocyte identity

    Article • EMBO Reports, July 2023, EMBO

    Laurent Dubuquoy, Dr. Alexandre Berthier

  9. A time- and space-resolved nuclear receptor atlas in mouse liver

    Article • Journal of Molecular Endocrinology, March 2023, Bioscientifica

    Dr. Alexandre Berthier

  10. A time- and space-resolved nuclear receptor atlas in mouse liver

    Article • January 2023, openRxiv

    Dr. Alexandre Berthier

  11. Control of lipid metabolism by the dynamic and nutrient‐dependent post‐translational modification O ‐GlcNAcylation

    Article • Natural Sciences, January 2023, Wiley

    Dr. Alexandre Berthier

  12. Timed use of digoxin prevents heart ischemia–reperfusion injury through a REV-ERBα–UPS signaling pathway

    Article • Nature Cardiovascular Research, November 2022, Springer Science + Business Media

    Dr. Alexandre Berthier

  13. An optimized protocol with a stepwise approach to identify specific nuclear receptor ligands from cultured mammalian cells

    Article • STAR Protocols, September 2021, Elsevier

    Dr. Alexandre Berthier

  14. PPARs in liver physiology

    Article • Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, May 2021, Elsevier

    Dr. Alexandre Berthier

  15. Combinatorial regulation of hepatic cytoplasmic signaling and nuclear transcriptional events by the OGT/REV-ERBα complex

    Article • Proceedings of the National Academy of Sciences, November 2018, Proceedings of the National Academy of Sciences

    Dr. Alexandre Berthier

  16. The nuclear bile acid receptor FXR is a PKA- and FOXA2-sensitive activator of fasting hepatic gluconeogenesis

    Article • Journal of Hepatology, November 2018, Elsevier

    Dr. Alexandre Berthier

  17. Development and implementation of a cell-based assay to discover agonists of the nuclear receptor REV-ERBα

    Article • Journal of Biological Methods, July 2018, Journal of Biological Methods

    Dr. Alexandre Berthier

  18. Daytime variation of perioperative myocardial injury in cardiac surgery and its prevention by Rev-Erbα antagonism: a single-centre propensity-matched cohort study and a randomised study

    Article • The Lancet, January 2018, Elsevier

    Dr. Alexandre Berthier

  19. The RBM14/CoAA-interacting, long intergenic non-coding RNA Paral1 regulates adipogenesis and coactivates the nuclear receptor PPARγ

    Article • Scientific Reports, October 2017, Springer Science + Business Media

    Dr. Alexandre Berthier

  20. Metformin interferes with bile acid homeostasis through AMPK-FXR crosstalk

    Article • Journal of Clinical Investigation, February 2014, American Society for Clinical Investigation

    Dr. Alexandre Berthier

  21. Glutathione S-Transferases Interact with AMP-Activated Protein Kinase: Evidence for S-Glutathionylation and Activation In Vitro

    Article • PLOS One, May 2013, PLOS

    Dr. Alexandre Berthier

  22. The Novel Antibacterial Compound Walrycin A Induces Human PXR Transcriptional Activity

    Article • Toxicological Sciences, February 2012, Oxford University Press (OUP)

    Dr. Alexandre Berthier

  23. Label‐free sensing and atomic force spectroscopy for the characterization of protein–DNA and protein–protein interactions: application to estrogen receptors

    Article • Journal of Molecular Recognition, April 2011, Wiley

    Dr. Alexandre Berthier

  24. High expression of gabarapl1 is associated with a better outcome for patients with lymph node-positive breast cancer

    Article • British Journal of Cancer, March 2010, Springer Science + Business Media

    Dr. Alexandre Berthier

  25. Gold/Silica biochips: Applications to Surface Plasmon Resonance and fluorescence quenching

    Article • Laser Physics, February 2009, Pleiades Publishing Ltd

    Dr. Alexandre Berthier

  26. Nanobioengineering and Characterization of a Novel Estrogen Receptor Biosensor

    Article • Sensors, July 2008, MDPI AG

    Dr. Alexandre Berthier

  27. Effect of 7-O-β-D-Glucopyranosylchrysin and its Aglycone Chrysin Isolated from Podocytisus caramanicus on Estrogen Receptor α Transcriptional Activity

    Article • Planta Medica, November 2007, Thieme Publishing Group

    Dr. Alexandre Berthier