All Stories

  1. Cancer suppresses mitochondrial chaperone activity in macrophages to drive immune evasion

    Article • Nature Immunology, October 2025, Springer Science + Business Media

    Alex Huang

  2. Engineering TME-gated inducible CAR-T cell therapy for solid tumors

    Article • Molecular Therapy, August 2025, Elsevier

    Alex Huang

  3. Piezo1deletion enhances cross-priming of CD8+ T cells by tumor-infiltrating CD11b+ dendritic cells

    Article • Journal for ImmunoTherapy of Cancer, June 2025, BMJ

    Alex Huang

  4. Piezo1 restrains proinflammatory response but is essential in T-cell–mediated immunopathology

    Article • Journal of Leukocyte Biology, November 2024, Oxford University Press (OUP)

    Alex Huang

  5. Oral transforming growth factor‐beta receptor 1 inhibitor vactosertib promotes osteosarcoma regression by targeting tumor proliferation and enhancing anti‐tumor immunity

    Article • Cancer Communications, July 2024, Wiley

    Alex Huang

  6. Targeting the chromatin binding of exportin-1 disrupts NFAT and T cell activation

    Article • Nature Chemical Biology, March 2024, Springer Science + Business Media

    Alex Huang

  7. Neutrophil extracellular traps induced by chemotherapy inhibit tumor growth in murine models of colorectal cancer

    Article • Journal of Clinical Investigation, January 2024, American Society for Clinical Investigation

    Alex Huang

  8. Piezo1 facilitates optimal T cell activation during tumor challenge

    Article • OncoImmunology, November 2023, Taylor & Francis

    Alex Huang

  9. Cryoablation-induced immune response is dependent on functional STING signaling in cancer cells

    Article • Journal for ImmunoTherapy of Cancer, August 2023, BMJ

    Alex Huang

  10. Adolescent and Young Adult (AYA) Oncology, Version 2.2024, NCCN Clinical Practice Guidelines in Oncology

    Article • Journal of the National Comprehensive Cancer Network, August 2023, Harborside Press, LLC

    Alex Huang

  11. Data from p35 is a Crucial Player in NK-cell Cytotoxicity and TGFβ-mediated NK-cell Dysfunction

    Article • May 2023, American Association for Cancer Research (AACR)

    Alex Huang

  12. Data from p35 is a Crucial Player in NK-cell Cytotoxicity and TGFβ-mediated NK-cell Dysfunction

    Article • May 2023, American Association for Cancer Research (AACR)

    Alex Huang

  13. FIGURE 2 from p35 is a Crucial Player in NK-cell Cytotoxicity and TGFβ-mediated NK-cell Dysfunction

    Article • May 2023, American Association for Cancer Research (AACR)

    Alex Huang

  14. FIGURE 2 from p35 is a Crucial Player in NK-cell Cytotoxicity and TGFβ-mediated NK-cell Dysfunction

    Article • May 2023, American Association for Cancer Research (AACR)

    Alex Huang

  15. FIGURE 3 from p35 is a Crucial Player in NK-cell Cytotoxicity and TGFβ-mediated NK-cell Dysfunction

    Article • May 2023, American Association for Cancer Research (AACR)

    Alex Huang

  16. FIGURE 3 from p35 is a Crucial Player in NK-cell Cytotoxicity and TGFβ-mediated NK-cell Dysfunction

    Article • May 2023, American Association for Cancer Research (AACR)

    Alex Huang

  17. FIGURE 4 from p35 is a Crucial Player in NK-cell Cytotoxicity and TGFβ-mediated NK-cell Dysfunction

    Article • May 2023, American Association for Cancer Research (AACR)

    Alex Huang

  18. FIGURE 4 from p35 is a Crucial Player in NK-cell Cytotoxicity and TGFβ-mediated NK-cell Dysfunction

    Article • May 2023, American Association for Cancer Research (AACR)

    Alex Huang

  19. FIGURE 5 from p35 is a Crucial Player in NK-cell Cytotoxicity and TGFβ-mediated NK-cell Dysfunction

    Article • May 2023, American Association for Cancer Research (AACR)

    Alex Huang

  20. FIGURE 5 from p35 is a Crucial Player in NK-cell Cytotoxicity and TGFβ-mediated NK-cell Dysfunction

    Article • May 2023, American Association for Cancer Research (AACR)

    Alex Huang

  21. FIGURE 6 from p35 is a Crucial Player in NK-cell Cytotoxicity and TGFβ-mediated NK-cell Dysfunction

    Article • May 2023, American Association for Cancer Research (AACR)

    Alex Huang

  22. FIGURE 6 from p35 is a Crucial Player in NK-cell Cytotoxicity and TGFβ-mediated NK-cell Dysfunction

    Article • May 2023, American Association for Cancer Research (AACR)

    Alex Huang

  23. p35 is a Crucial Player in NK-cell Cytotoxicity and TGFβ-mediated NK-cell Dysfunction

    Article • Cancer Research Communications, May 2023, American Association for Cancer Research (AACR)

    Alex Huang

  24. PIEZO1Deletion in CD11b+ Cells Suppresses Rhabdomyosarcoma Tumor Rejection and Generates a Tumor-Permissive Immune Landscape

    Article • The Journal of Immunology, May 2023, The American Association of Immunologists

    Alex Huang

  25. Oral TGF-βR1 inhibitor Vactosertib promotes osteosarcoma regression by targeting tumor proliferation and enhancing anti-tumor immunity

    Article • April 2023, Research Square

    Alex Huang

  26. Ectopic Tumor VCAM-1 Expression in Cancer Metastasis and Therapy Resistance

    Article • Cells, December 2022, MDPI AG

    Alex Huang

  27. Overexpression of VEGF in the MOPC 315 Plasmacytoma Induces Tumor Immunity in Mice

    Article • International Journal of Molecular Sciences, May 2022, MDPI AG

    Alex Huang

  28. Detailing the mechanism of CDK5-mediated PD-L1 regulation in Medulloblastoma

    Article • The Journal of Immunology, May 2020, The American Association of Immunologists

    Alex Huang

  29. Winnie-APCMin/+ Mice: A Spontaneous Model of Colitis-Associated Colorectal Cancer Combining Genetics and Inflammation

    Article • International Journal of Molecular Sciences, April 2020, MDPI AG

    Alex Huang

  30. Intravenous immunoglobulin therapy enhances suppressive regulatory T cells and decreases innate lymphoid cells in children with immune thrombocytopenia

    Article • Pediatric Blood & Cancer, November 2019, Wiley

    Alex Huang

  31. Chemical disruption of the pyroptotic pore-forming protein gasdermin D inhibits inflammatory cell death and sepsis

    Article • Science Immunology, August 2018, American Association for the Advancement of Science

    Alex Huang

  32. Biomimetic post-capillary venule expansions for leukocyte adhesion studies

    Article • Scientific Reports, June 2018, Springer Science + Business Media

    Prof. Umut A Gurkan, Alex Huang

  33. Optimizing Tumor Microenvironment for Cancer Immunotherapy: β-Glucan-Based Nanoparticles

    Article • Frontiers in Immunology, February 2018, Frontiers

    Alex Huang

  34. Multifactorial regulators of tumor programmed death-ligand 1 (PD-L1) response

    Article • Translational Cancer Research, December 2017, AME Publishing Company

    Alex Huang

  35. CCL3 augments tumor rejection and enhances CD8+ T cell infiltration through NK and CD103+ dendritic cell recruitment via IFNγ

    Article • OncoImmunology, November 2017, Taylor & Francis

    Alex Huang

  36. Systemic administration of β-glucan of 200 kDa modulates melanoma microenvironment and suppresses metastatic cancer

    Article • OncoImmunology, October 2017, Taylor & Francis

    Alex Huang

  37. CCL3 Enhances Antitumor Immune Priming in the Lymph Node via IFNγ with Dependency on Natural Killer Cells

    Article • Frontiers in Immunology, October 2017, Frontiers

    Alex Huang

  38. Live-cell visualization of gasdermin D-driven pyroptotic cell death

    Article • Journal of Biological Chemistry, September 2017, Elsevier

    Alex Huang

  39. Notch2 blockade enhances hematopoietic stem cell mobilization and homing

    Article • Haematologica, July 2017, Ferrata Storti Foundation (Haematologica)

    Alex Huang

  40. Nanoparticle Systems Modulating Myeloid-Derived Suppressor Cells for Cancer Immunotherapy

    Article • Current Topics in Medicinal Chemistry, April 2017, Bentham Science Publishers

    Alex Huang

  41. Fibroblastic niches prime T cell alloimmunity through Delta-like Notch ligands

    Article • Journal of Clinical Investigation, March 2017, American Society for Clinical Investigation

    Alex Huang

  42. Adoptive natural killer cell therapy is effective in reducing pulmonary metastasis of Ewing sarcoma

    Article • OncoImmunology, March 2017, Taylor & Francis

    Alex Huang

  43. Plant viral nanoparticles-based HER2 vaccine: Immune response influenced by differential transport, localization and cellular interactions of particulate carriers

    Article • Biomaterials, March 2017, Elsevier

    Alex Huang

  44. Cyclin-dependent kinase 5 activity is required for allogeneic T-cell responses after hematopoietic cell transplantation in mice

    Article • Blood, November 2016, American Society of Hematology

    Alex Huang

  45. Abstract A050: Cdk5 disruption attenuates tumor PD-L1 expression via regulation of IFN-γ signaling components and promotes antitumor immunity

    Article • Cancer Immunology Research, October 2016, American Association for Cancer Research (AACR)

    Alex Huang

  46. Cdk5 disruption attenuates tumor PD-L1 expression and promotes antitumor immunity

    Article • Science, July 2016, American Association for the Advancement of Science

    Alex Huang

  47. Transforming growth factor-β1 sustains the survival of Foxp3+ regulatory cells during late phase of oropharyngeal candidiasis infection

    Article • Mucosal Immunology, July 2016, Elsevier

    Alex Huang

  48. Unique Transcompartmental Bridge: Antigen-Presenting Cells Sampling across Endothelial and Mucosal Barriers

    Article • Frontiers in Immunology, June 2016, Frontiers

    Alex Huang

  49. Transient Surface CCR5 Expression by Naive CD8+ T Cells within Inflamed Lymph Nodes Is Dependent on High Endothelial Venule Interaction and Augments Th Cell–Dependent Memory Response

    Article • The Journal of Immunology, May 2016, The American Association of Immunologists

    Alex Huang

  50. Multiple Administrations of Viral Nanoparticles Alter in Vivo Behavior—Insights from Intravital Microscopy

    Article • ACS Biomaterials Science & Engineering, April 2016, American Chemical Society (ACS)

    Alex Huang

  51. Aberrant Notch Signaling in the Bone Marrow Microenvironment of Acute Lymphoid Leukemia Suppresses Osteoblast-Mediated Support of Hematopoietic Niche Function

    Article • Cancer Research, January 2016, American Association for Cancer Research (AACR)

    Alex Huang

  52. Abstract IA28: Immunological insights from tracking dynamic cellular behavior in lymph nodes and tissues

    Article • Cancer Immunology Research, January 2016, American Association for Cancer Research (AACR)

    Alex Huang

  53. Abstract B158: Cyclin dependent kinase-5 regulates IFNγ induced PD-L1 expression via IRF-1 in medulloblastoma

    Article • Cancer Immunology Research, January 2016, American Association for Cancer Research (AACR)

    Alex Huang

  54. Cx25 contributes to leukemia cell communication and chemosensitivity

    Article • Oncotarget, August 2015, Impact Journals, LLC

    Alex Huang

  55. Polyphenol administration impairs T-cell proliferation by imprinting a distinct dendritic cell maturational profile

    Article • European Journal of Immunology, July 2015, Wiley

    Marcello Chieppa, Alex Huang

  56. Dysregulated Intrahepatic CD4+ T-Cell Activation Drives Liver Inflammation in Ileitis-Prone SAMP1/YitFc Mice

    Article • Cellular and Molecular Gastroenterology and Hepatology, July 2015, Elsevier

    Alex Huang

  57. Notch Receptor-Ligand Engagement Maintains Hematopoietic Stem Cell Quiescence and Niche Retention

    Article • Stem Cells, May 2015, Wiley

    Dr Christian W Siebel, Alex Huang

  58. Focal transient CNS vessel leak provides a tissue niche for sequential immune cell accumulation during the asymptomatic phase of EAE induction

    Article • Experimental Neurology, April 2015, Elsevier

    Alex Huang

  59. Triterpenoid inducers of Nrf2 signaling as potential therapeutic agents in sickle cell disease: a review

    Article • Frontiers of Medicine, December 2014, Springer Science + Business Media

    Alex Huang

  60. Intravital Imaging of Axonal Interactions with Microglia and Macrophages in a Mouse Dorsal Column Crush Injury

    Article • Journal of Visualized Experiments, November 2014, MyJove Corporation

    Alex Huang

  61. The roles of blood-derived macrophages and resident microglia in the neuroinflammatory response to implanted Intracortical microelectrodes

    Article • Biomaterials, September 2014, Elsevier

    Alex Huang

  62. Comparison of intravital thinned skull and cranial window approaches to study CNS immunobiology in the mouse cortex

    Article • IntraVital, May 2014, Taylor & Francis

    Alex Huang

  63. High-resolution intravital imaging reveals that blood-derived macrophages but not resident microglia facilitate secondary axonal dieback in traumatic spinal cord injury

    Article • Experimental Neurology, April 2014, Elsevier

    Alex Huang

  64. Administration of Reconstituted Polyphenol Oil Bodies Efficiently Suppresses Dendritic Cell Inflammatory Pathways and Acute Intestinal Inflammation

    Article • PLOS One, February 2014, PLOS

    Alex Huang

  65. The prevalence of hypertension and abnormal kidney function in children with sickle cell disease –a cross sectional review

    Article • BMC Nephrology, October 2013, Springer Science + Business Media

    Alex Huang

  66. Chemokines as Cancer Vaccine Adjuvants

    Article • Vaccines, October 2013, MDPI AG

    Alex Huang

  67. Extravascular CX3CR1+Cells Extend Intravascular Dendritic Processes into Intact Central Nervous System Vessel Lumen

    Article • Microscopy and Microanalysis, May 2013, Oxford University Press (OUP)

    Alex Huang

  68. Dynamic Imaging of Marrow-Resident Granulocytes Interacting with Human Mesenchymal Stem Cells upon Systemic Lipopolysaccharide Challenge

    Article • Stem Cells International, January 2013, Hindawi Publishing Corporation

    Alex Huang

  69. Viewing Transplantation Immunology Through Today's Lens: New Models, New Imaging, and New Insights

    Article • Biology of Blood and Marrow Transplantation, January 2013, Elsevier

    Alex Huang

  70. Quantification of lymph node transit times reveals differences in antigen surveillance strategies of naïve CD4 + and CD8 + T cells

    Article • Proceedings of the National Academy of Sciences, October 2012, Proceedings of the National Academy of Sciences

    Alex Huang

  71. Cutaneous penetration of the topically applied photosensitizer Pc 4 as detected by intravital 2-photon laser scanning microscopy

    Article • Photodiagnosis and Photodynamic Therapy, September 2012, Elsevier

    Alex Huang

  72. Intravital Imaging of the Mouse Popliteal Lymph Node

    Article • Journal of Visualized Experiments, February 2012, MyJove Corporation

    Alex Huang

  73. Direct In Vivo Evidence for Tumor Propagation by Glioblastoma Cancer Stem Cells

    Article • PLOS One, September 2011, PLOS

    Alex Huang

  74. Establishing a Novel In Vivo Platform to Interrogate the Effects of Pharmacologic and Molecularly Targeted Modulation of CDK5 in the Invasive and Metastatic Potential of Medulloblastoma in Live Experimental Animals

    Article • Microscopy and Microanalysis, July 2011, Cambridge University Press

    Alex Huang

  75. Direct Visualization of Tumor Propagation by Cancer Stem Cells and Associated Tissue Responses

    Article • Microscopy and Microanalysis, July 2011, Cambridge University Press

    Alex Huang

  76. A Novel Role for Lymphocyte Expression of the Cyclin-Dependent Kinase 5 (CDK5) in the Generation of Allogeneic T Cell Responses After BMT

    Article • Biology of Blood and Marrow Transplantation, February 2011, Elsevier

    Alex Huang

  77. Cyclin-dependent kinase 5 activity is required for T cell activation and induction of experimental autoimmune encephalomyelitis

    Article • Journal of Cell Biology, October 2010, Rockefeller University Press

    Alex Huang

  78. Cyclin-dependent kinase 5 activity is required for T cell activation and induction of experimental autoimmune encephalomyelitis

    Article • Journal of Experimental Medicine, October 2010, Rockefeller University Press

    Alex Huang

  79. Mycobacterium tuberculosis and TLR2 Agonists Inhibit Induction of Type I IFN and Class I MHC Antigen Cross Processing by TLR9

    Article • The Journal of Immunology, August 2010, The American Association of Immunologists

    Alex Huang

  80. Fucose-deficient hematopoietic stem cells have decreased self-renewal and aberrant marrow niche occupancy

    Article • Transfusion, June 2010, Wiley

    Alex Huang

  81. Bulging glands? Blame it on B cells

    Article • Blood, June 2010, American Society of Hematology

    Alex Huang

  82. Visualizing Immune Surveillance in Tumor Microenvironment with Two-photon Microscopy

    Article • Microscopy and Microanalysis, July 2009, Oxford University Press (OUP)

    Alex Huang

  83. Comparative ultrastructural study of human corpus cavernosum during ageing

    Article • Microscopy and Microanalysis, September 2008, Oxford University Press (OUP)

    Alex Huang

  84. Making friends in out-of-the-way places: how cells of the immune system get together and how they conduct their business as revealed by intravital imaging

    Article • Immunological Reviews, February 2008, Wiley

    Alex Huang

  85. Highways, byways and breadcrumbs: directing lymphocyte traffic in the lymph node

    Article • Trends in Immunology, August 2007, Elsevier

    Alex Huang

  86. L-selectin-negative CCR7− effector and memory CD8+ T cells enter reactive lymph nodes and kill dendritic cells

    Article • Nature Immunology, May 2007, Springer Science + Business Media

    Alex Huang

  87. Watching Immune Cells in Action

    Article • Biology of Blood and Marrow Transplantation, January 2007, Elsevier

    Alex Huang

  88. Dynamic imaging of dendritic cell extension into the small bowel lumen in response to epithelial cell TLR engagement

    Article • Journal of Experimental Medicine, December 2006, Rockefeller University Press

    Alex Huang

  89. Extrafollicular Activation of Lymph Node B Cells by Antigen-Bearing Dendritic Cells

    Article • Science, June 2006, American Association for the Advancement of Science

    Alex Huang

  90. Intravital 2-Photon Microscopy of Dendritic Cell Extension Sampling Pathogen Bacteria Into the Small Bowel Lumen

    Article • Inflammatory Bowel Diseases, April 2006, Wolters Kluwer Health

    Alex Huang

  91. Chemokines enhance immunity by guiding naive CD8+ T cells to sites of CD4+ T cell–dendritic cell interaction

    Article • Nature, April 2006, Springer Science + Business Media

    Alex Huang

  92. Natural killer cell behavior in lymph nodes revealed by static and real-time imaging

    Article • Journal of Experimental Medicine, February 2006, Rockefeller University Press

    Alex Huang

  93. An extended vision for dynamic high-resolution intravital immune imaging

    Article • Seminars in Immunology, December 2005, Elsevier

    Alex Huang

  94. Illuminating the Landscape of In Vivo Immunity

    Article • Immunity, September 2004, Elsevier

    Alex Huang

  95. Antigen-specific cancer immunotherapy using a GM-CSF secreting allogeneic tumor cell-based vaccine

    Article • International Journal of Cancer, June 2000, Wiley

    Alex Huang

  96. The immunodominant major histocompatibility complex class I-restricted antigen of a murine colon tumor derives from an endogenous retroviral gene product.

    Article • Proceedings of the National Academy of Sciences, September 1996, Proceedings of the National Academy of Sciences

    Alex Huang

  97. Enhanced Immune Priming with Spatial Distribution of Paracrine Cytokine Vaccines

    Article • Journal of Immunotherapy, May 1996, Wolters Kluwer Health

    Alex Huang

  98. In Vivo Cross-Priming of MHC Class I–Restricted Antigens Requires the TAP Transporter

    Article • Immunity, April 1996, Elsevier

    Alex Huang

  99. Does B7-1 expression confer antigen-presenting cell capacity to tumors in vivo?

    Article • Journal of Experimental Medicine, March 1996, Rockefeller University Press

    Alex Huang

  100. A reassessment of the role of B7-1 expression in tumor rejection.

    Article • Journal of Experimental Medicine, November 1995, Rockefeller University Press

    Alex Huang

  101. Localization of epstein-barr virus-encoded small RNA-1 by in situ reverse transcription: Demonstration of cDNA generation in formalin-fixed paraffin-embedded tissue sections

    Article • Journal of Biomedical Science, August 1995, Springer Science + Business Media

    Alex Huang

  102. Simplified High-Sensitivity Sequencing of a Major Histocompatibility Complex Class I-Associated Immunoreactive Peptide Using Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry

    Article • Analytical Biochemistry, March 1995, Elsevier

    Alex Huang

  103. Photodehalogenation of 4-haloindoles

    Article • Journal of the American Chemical Society, September 1989, American Chemical Society (ACS)

    Alex Huang