All Stories

  1. Pathologic gene network rewiring implicates PPP1R3A as a central regulator in pressure overload heart failure

    Article • Nature Communications, June 2019, Springer Science + Business Media

    Alex Chia Yu Chang

  2. Modelling diastolic dysfunction in induced pluripotent stem cell-derived cardiomyocytes from hypertrophic cardiomyopathy patients

    Article • European Heart Journal, June 2019, Oxford University Press (OUP)

    Alex Chia Yu Chang

  3. A Human iPSC Double-Reporter System Enables Purification of Cardiac Lineage Subpopulations with Distinct Function and Drug Response Profiles

    Article • Cell Stem Cell, May 2019, Elsevier

    Alex Chia Yu Chang

  4. An In Vitro Model for Identifying Cardiac Side Effects of Anesthetics

    Article • Anesthesia & Analgesia, September 2018, Wolters Kluwer Health

    Alex Chia Yu Chang, Alex Chia Yu Chang

  5. Telomere shortening is a hallmark of genetic cardiomyopathies

    Article • Proceedings of the National Academy of Sciences, August 2018, Proceedings of the National Academy of Sciences

    Alex Chia Yu Chang

  6. Apelin and APJ orchestrate complex tissue-specific control of cardiomyocyte hypertrophy and contractility in the hypertrophy-heart failure transition

    Article • AJP Heart and Circulatory Physiology, August 2018, American Physiological Society

    Alex Chia Yu Chang, Alex Chia Yu Chang

  7. Short telomeres — A hallmark of heritable cardiomyopathies

    Article • Differentiation, March 2018, Elsevier

    Alex Chia Yu Chang, Alex Chia Yu Chang

  8. Humanizing the mdx mouse model of DMD: the long and the short of it

    Article • npj Regenerative Medicine, February 2018, Springer Science + Business Media

    Alex Chia Yu Chang, Alex Chia Yu Chang

  9. Telomere shortening and metabolic compromise underlie dystrophic cardiomyopathy

    Article • Proceedings of the National Academy of Sciences, October 2016, Proceedings of the National Academy of Sciences

    Alex Chia Yu Chang, Alex Chia Yu Chang

  10. Human induced pluripotent stem cell–derived cardiomyocytes recapitulate the predilection of breast cancer patients to doxorubicin-induced cardiotoxicity

    Article • Nature Reports Stem Cells, April 2016, Springer Science + Business Media

    Alex Chia Yu Chang, Alex Chia Yu Chang

  11. A Notch-dependent transcriptional hierarchy promotes mesenchymal transdifferentiation in the cardiac cushion

    Article • Developmental Dynamics, April 2014, Wiley

    Alex Chia Yu Chang, Alex Chia Yu Chang

  12. Notch activation augments nitric oxide/soluble guanylyl cyclase signaling in immortalized ovarian surface epithelial cells and ovarian cancer cells

    Article • Cellular Signalling, December 2013, Elsevier

    Alex Chia Yu Chang, Alex Chia Yu Chang

  13. Notch-Dependent Regulation of the Ischemic Vasodilatory Response—Brief Report

    Article • Arteriosclerosis Thrombosis and Vascular Biology, March 2013, Wolters Kluwer Health

    Alex Chia Yu Chang

  14. Co-ordinating Notch, BMP, and TGF-β signaling during heart valve development

    Article • Cellular and Molecular Life Sciences, November 2012, Springer Science + Business Media

    Alex Chia Yu Chang, Alex Chia Yu Chang

  15. Twist1 Transcriptional Targets in the Developing Atrio-Ventricular Canal of the Mouse

    Article • PLOS One, July 2012, PLOS

    Alex Chia Yu Chang, Alex Chia Yu Chang

  16. Notch Initiates the Endothelial-to-Mesenchymal Transition in the Atrioventricular Canal through Autocrine Activation of Soluble Guanylyl Cyclase

    Article • Developmental Cell, August 2011, Elsevier

    Alex Chia Yu Chang, Alex Chia Yu Chang

  17. RUNX3 Maintains the Mesenchymal Phenotype after Termination of the Notch Signal

    Article • Journal of Biological Chemistry, February 2011, American Society for Biochemistry & Molecular Biology (ASBMB)

    Alex Chia Yu Chang, Alex Chia Yu Chang

  18. Genomic analysis distinguishes phases of early development of the mouse atrio-ventricular canal

    Article • Physiological Genomics, February 2010, American Physiological Society

    Alex Chia Yu Chang, Alex Chia Yu Chang

  19. Differential Regulation of Transforming Growth Factor β Signaling Pathways by Notch in Human Endothelial Cells

    Article • Journal of Biological Chemistry, May 2009, American Society for Biochemistry & Molecular Biology (ASBMB)

    Alex Chia Yu Chang, Alex Chia Yu Chang

  20. Probing the structure and function of an archaeal C/D-box methylation guide sRNA

    Article • RNA, July 2006, Cold Spring Harbor Laboratory Press

    Alex Chia Yu Chang, Alex Chia Yu Chang