All Stories

  1. On the antioxidant activity of eumelanin biopigments: a quantitative comparison between free radical scavenging and redox properties

    Article • Natural Product Research, January 2019, Taylor & Francis

    Dr Alessandro Pezzella, Anthony Camus

  2. Stem cell-compatible eumelanin biointerface fabricated by chemically controlled solid state polymerization

    Article • Materials Horizons, January 2015, Royal Society of Chemistry

    Dr Alessandro Pezzella, Professor Marco d'Ischia

  3. Supplementing π-systems: eumelanin and graphene-like integration towards highly conductive materials for the mammalian cell culture bio-interface

    Article • Journal of Materials Chemistry B, January 2015, Royal Society of Chemistry

    Dr Alessandro Pezzella

  4. Superior Photoprotective Motifs and Mechanisms in Eumelanins Uncovered

    Article • Journal of the American Chemical Society, August 2014, American Chemical Society (ACS)

    Dr Alessandro Pezzella, Professor Marco d'Ischia

  5. Bioelectronics: In Situ Formation of Dendrites in Eumelanin Thin Films between Gold Electrodes (Adv. Funct. Mater. 45/2013)

    Article • Advanced Functional Materials, December 2013, Wiley

    Dr Alessandro Pezzella

  6. Neuroglobin Modification by Reactive Quinone Species

    Article • Chemical Research in Toxicology, November 2013, American Chemical Society (ACS)

    Dr Alessandro Pezzella

  7. Eumelanin: An Old Natural Pigment and a New Material for Organic Electronics – Chemical, Physical, and Structural Properties in Relation to Potential Applications

    Article • August 2013, Wiley

    Dr Alessandro Pezzella

  8. Free Radical Coupling of o-Semiquinones Uncovered

    Article • Journal of the American Chemical Society, July 2013, American Chemical Society (ACS)

    Dr Alessandro Pezzella, Professor Marco d'Ischia

  9. Melanins and melanogenesis: methods, standards, protocols

    Article • Pigment Cell & Melanoma Research, June 2013, Wiley

    Dr Alessandro Pezzella, Professor Marco d'Ischia

  10. In Situ Formation of Dendrites in Eumelanin Thin Films between Gold Electrodes

    Article • Advanced Functional Materials, June 2013, Wiley

    Dr Alessandro Pezzella, Luis Cardenas

  11. Excited-State Proton-Transfer Processes of DHICA Resolved: From Sub-Picoseconds to Nanoseconds

    Article • The Journal of Physical Chemistry Letters, April 2013, American Chemical Society (ACS)

    Dr Alessandro Pezzella, Professor Marco d'Ischia

  12. Towards the development of a novel bioinspired functional material: Synthesis and characterization of hybrid TiO2/DHICA-melanin nanoparticles

    Article • Materials Science and Engineering C, January 2013, Elsevier

    Dr Alessandro Pezzella

  13. Irreversible evolution of eumelanin redox states detected by an organic electrochemical transistor: en route to bioelectronics and biosensing

    Article • Journal of Materials Chemistry B, January 2013, Royal Society of Chemistry

    Dr Alessandro Pezzella, Professor Marco d'Ischia, Dr Pasquale D'Angelo

  14. Intermolecular π‐Electron Perturbations Generate Extrinsic Visible Contributions to Eumelanin Black Chromophore in Model Polymers with Interrupted Interring Conjugation

    Article • Photochemistry and Photobiology, November 2012, Wiley

    Dr Alessandro Pezzella, Professor Marco d'Ischia

  15. Bottom-Up Approach to Eumelanin Photoprotection: Emission Dynamics in Parallel Sets of Water-Soluble 5,6-Dihydroxyindole-Based Model Systems

    Article • The Journal of Physical Chemistry B, October 2012, American Chemical Society (ACS)

    Dr Alessandro Pezzella, Professor Marco d'Ischia

  16. Heparin conjugated silica nanoparticle synthesis

    Article • Materials Science and Engineering C, October 2012, Elsevier

    Dr Alessandro Pezzella

  17. Glycosylated Eumelanin Building Blocks by Thioglycosylation of 5,6‐Diacetoxyindole with an Expedient Selenium‐Based Dynamic‐Mixture Methodology

    Article • European Journal of Organic Chemistry, August 2012, Wiley

    Dr Alessandro Pezzella, Professor Marco d'Ischia

  18. Eumelanin Buildup on the Nanoscale: Aggregate Growth/Assembly and Visible Absorption Development in Biomimetic 5,6-Dihydroxyindole Polymerization.

    Article • Biomacromolecules, July 2012, American Chemical Society (ACS)

    Dr Alessandro Pezzella, Professor Marco d'Ischia

  19. Photovoltaic properties of PSi impregnated with eumelanin

    Article • Nanoscale Research Letters, July 2012, Springer Science + Business Media

    Dr Alessandro Pezzella

  20. Atropodiastereoselectivity in solid state BINOL synthesis: Leads from the estradiol platform

    Article • Steroids, May 2012, Elsevier

    Dr Alessandro Pezzella, Professor Marco d'Ischia

  21. Exploring the frontiers of synthetic eumelanin polymers by high‐resolution matrix‐assisted laser/desorption ionization mass spectrometry

    Article • Journal of Mass Spectrometry, January 2012, Wiley

    Dr Alessandro Pezzella, Professor Marco d'Ischia

  22. 5,6‐Dihydroxyindole Chemistry: Unexplored Opportunities Beyond Eumelanin

    Article • European Journal of Organic Chemistry, September 2011, Wiley

    Dr Alessandro Pezzella, Professor Marco d'Ischia

  23. Structure of Melanins

    Article • June 2011, Wiley

    Dr Alessandro Pezzella, Professor Marco d'Ischia

  24. π-Electron Manipulation of the 5,6-Dihydroxyindole/Quinone System by 3-Alkynylation: Mild Acid-Mediated Entry to (Cross)-Conjugated Scaffolds and Paradigms for Medium-Tunable Chromophores

    Article • The Journal of Organic Chemistry, May 2011, American Chemical Society (ACS)

    Dr Alessandro Pezzella, Professor Marco d'Ischia

  25. Functionality of epidermal melanin pigments: current knowledge on UV-dissipative mechanisms and research perspectives

    Article • Physical Chemistry Chemical Physics, January 2011, Royal Society of Chemistry

    Dr Alessandro Pezzella

  26. UV‐Dissipation Mechanisms in the Eumelanin Building Block DHICA

    Article • ChemPhysChem, July 2010, Wiley

    Dr Alessandro Pezzella, Professor Marco d'Ischia

  27. Cyclic Structural Motifs in 5,6-Dihydroxyindole Polymerization Uncovered: Biomimetic Modular Buildup of a Unique Five-Membered Macrocycle

    Article • Organic Letters, June 2010, American Chemical Society (ACS)

    Dr Alessandro Pezzella, Professor Marco d'Ischia

  28. Reaction of dihydrolipoic acid with juglone and related naphthoquinones: unmasking of a spirocyclic 1,3-dithiane intermediate en route to naphtho[1,4]dithiepines

    Article • Tetrahedron, May 2010, Elsevier

    Dr Alessandro Pezzella, Professor Marco d'Ischia

  29. 5,6‐Dihydroxyindole Oxidation in Phosphate Buffer/Polyvinyl Alcohol: A New Model System for Studies of Visible Chromophore Development in Synthetic Eumelanin Polymers

    Article • Photochemistry and Photobiology, May 2010, Wiley

    Dr Alessandro Pezzella, Professor Marco d'Ischia

  30. First synthetic entry to the trimer stage of 5,6-dihydroxyindole polymerization: ortho-alkynylaniline-based access to the missing 2,7′:2′,7′′-triindole

    Article • Organic & Biomolecular Chemistry, January 2010, Royal Society of Chemistry

    Paola Manini, Dr Alessandro Pezzella, Professor Marco d'Ischia

  31. Disentangling Eumelanin “Black Chromophore”: Visible Absorption Changes As Signatures of Oxidation State- and Aggregation-Dependent Dynamic Interactions in a Model Water-Soluble 5,6-Dihydroxyindole Polymer

    Article • Journal of the American Chemical Society, October 2009, American Chemical Society (ACS)

    Dr Alessandro Pezzella, Professor Marco d'Ischia

  32. Ultrafast Excited State Dynamics of 5,6-Dihydroxyindole, A Key Eumelanin Building Block: Nonradiative Decay Mechanism

    Article • The Journal of Physical Chemistry B, August 2009, American Chemical Society (ACS)

    Dr Alessandro Pezzella, Professor Marco d'Ischia

  33. Efficient Synthesis of 5,6-Dihydroxyindole Dimers, Key Eumelanin Building Blocks, by a Unified o-Ethynylaniline-Based Strategy for the Construction of 2-Linked Biindolyl Scaffolds

    Article • The Journal of Organic Chemistry, August 2009, American Chemical Society (ACS)

    Dr Alessandro Pezzella, Professor Marco d'Ischia

  34. ChemInform Abstract: Chemical and Structural Diversity in Eumelanins: Unexplored Bio‐Optoelectronic Materials

    Article • ChemInform, July 2009, Wiley

    Dr Alessandro Pezzella, Professor Marco d'Ischia

  35. Chemische und strukturelle Vielfalt der Eumelanine – ein kaum erforschtes optoelektronisches Biopolymer

    Article • Angewandte Chemie, May 2009, Wiley

    Dr Alessandro Pezzella, Professor Marco d'Ischia

  36. Chemical and Structural Diversity in Eumelanins: Unexplored Bio‐Optoelectronic Materials

    Article • Angewandte Chemie International Edition, May 2009, Wiley

    Dr Alessandro Pezzella, Professor Marco d'Ischia

  37. Lack of Visible Chromophore Development in the Pulse Radiolysis Oxidation of 5,6-Dihydroxyindole-2-carboxylic Acid Oligomers: DFT Investigation and Implications for Eumelanin Absorption Properties

    Article • The Journal of Organic Chemistry, April 2009, American Chemical Society (ACS)

    Dr Alessandro Pezzella, Professor Marco d'Ischia, Ruth Edge

  38. A novel fluoride-sensing scaffold by a peculiar acid-promoted trimerization of 5,6-dihydroxyindole

    Article • Tetrahedron, March 2009, Elsevier

    Dr Alessandro Pezzella, Professor Marco d'Ischia

  39. Plant Catechols and Their S-Glutathionyl Conjugates as Antinitrosating Agents: Expedient Synthesis and Remarkable Potency of 5-S-Glutathionylpiceatannol

    Article • Chemical Research in Toxicology, October 2008, American Chemical Society (ACS)

    Dr Alessandro Pezzella, Professor Marco d'Ischia

  40. ChemInform Abstract: Mild and Efficient Iodination of Aromatic and Heterocyclic Compounds with the NaClO2/NaI/HCl System.

    Article • ChemInform, April 2008, Wiley

    Dr Alessandro Pezzella, Professor Marco d'Ischia

  41. Mild and efficient iodination of aromatic and heterocyclic compounds with the NaClO2/NaI/HCl system

    Article • Tetrahedron, January 2008, Elsevier

    Dr Alessandro Pezzella, Professor Marco d'Ischia

  42. Structural Effects on the Electronic Absorption Properties of 5,6‐Dihydroxyindole Oligomers: The Potential of an Integrated Experimental and DFT Approach to Model Eumelanin Optical Properties†

    Article • Photochemistry and Photobiology, December 2007, Wiley

    Dr Alessandro Pezzella, Professor Marco d'Ischia

  43. 5,6-Dihydroxyindole Tetramers with “Anomalous” Interunit Bonding Patterns by Oxidative Coupling of 5,5‘,6,6‘-Tetrahydroxy-2,7‘-biindolyl:  Emerging Complexities on the Way toward an Improved Model of Eumelanin Buildup

    Article • The Journal of Organic Chemistry, November 2007, American Chemical Society (ACS)

    Dr Alessandro Pezzella, Professor Marco d'Ischia

  44. The First Entry to 5,6‐Dihydroxy‐3‐mercaptoindole, 5‐Hydroxy‐3‐mercaptoindole and Their 2‐Carbomethoxy Derivatives by a Mild Thiocyanation/Reduction Methodology.

    Article • ChemInform, August 2007, Wiley

    Dr Alessandro Pezzella, Professor Marco d'Ischia

  45. The first entry to 5,6-dihydroxy-3-mercaptoindole, 5-hydroxy-3-mercaptoindole and their 2-carbomethoxy derivatives by a mild thiocyanation/reduction methodology

    Article • Tetrahedron Letters, May 2007, Elsevier

    Dr Alessandro Pezzella, Professor Marco d'Ischia

  46. The First 5,6-Dihydroxyindole Tetramer by Oxidation of 5,5‘,6,6‘-Tetrahydroxy- 2,4‘-biindolyl and an Unexpected Issue of Positional Reactivity en Route to Eumelanin-Related Polymers

    Article • Organic Letters, March 2007, American Chemical Society (ACS)

    Dr Alessandro Pezzella, Professor Marco d'Ischia

  47. Chemical, Pulse Radiolysis and Density Functional Studies of a New, Labile 5,6-Indolequinone and Its Semiquinone

    Article • The Journal of Organic Chemistry, February 2007, American Chemical Society (ACS)

    Dr Alessandro Pezzella, Professor Marco d'Ischia, Ruth Edge

  48. Preparation and Oxidation Chemistry of the Catechol Estrogens: Relevance to Estrogen-Related Carcinogenesis and Potential for Drug Design

    Article • Current Bioactive Compounds, December 2006, Bentham Science Publishers

    Dr Alessandro Pezzella, Professor Marco d'Ischia

  49. Short-Lived Quinonoid Species from 5,6-Dihydroxyindole Dimers en Route to Eumelanin Polymers:  Integrated Chemical, Pulse Radiolytic, and Quantum Mechanical Investigation

    Article • Journal of the American Chemical Society, November 2006, American Chemical Society (ACS)

    Dr Alessandro Pezzella, Professor Marco d'Ischia, Ruth Edge

  50. Practical one-pot conversion of 17β-estradiol to 10β-hydroxy- (p-quinol) and 10β-chloro-17β-hydroxyestra-1,4-dien-3-one

    Article • Steroids, August 2006, Elsevier

    Dr Alessandro Pezzella, Professor Marco d'Ischia

  51. The role of residue Thr249 in modulating the catalytic efficiency and substrate specificity of catechol‐2,3‐dioxygenase from Pseudomonas stutzeri OX1

    Article • FEBS Journal, June 2006, Wiley

    Dr Alessandro Pezzella

  52. Acid-Promoted Reaction of the Stilbene Antioxidant Resveratrol with Nitrite Ions:  Mild Phenolic Oxidation at the 4‘-Hydroxystiryl Sector Triggering Nitration, Dimerization, and Aldehyde-Forming Routes

    Article • The Journal of Organic Chemistry, April 2006, American Chemical Society (ACS)

    Dr Alessandro Pezzella, Professor Marco d'Ischia

  53. Oxidative chemistry of the natural antioxidant hydroxytyrosol: hydrogen peroxide-dependent hydroxylation and hydroxyquinone/o-quinone coupling pathways

    Article • Tetrahedron, February 2006, Elsevier

    Dr Alessandro Pezzella, Professor Marco d'Ischia

  54. 5,6‐Dihydroxyindoles and Indole‐5,6‐diones

    Article • ChemInform, January 2006, Wiley

    Dr Alessandro Pezzella, Professor Marco d'Ischia

  55. An Expedient One‐Pot Entry Catecholestrogens and Other Catechol Compounds via IBX‐Mediated Phenolic Oxygenation.

    Article • ChemInform, August 2005, Wiley

    Dr Alessandro Pezzella, Professor Marco d'Ischia

  56. Tyrosinase-Catalyzed Oxidation of 17β-Estradiol:  Structure Elucidation of the Products Formed beyond Catechol Estrogen Quinones

    Article • Chemical Research in Toxicology, August 2005, American Chemical Society (ACS)

    Dr Alessandro Pezzella, Professor Marco d'Ischia

  57. An expedient one-pot entry to catecholestrogens and other catechol compounds via IBX-mediated phenolic oxygenation

    Article • Tetrahedron Letters, May 2005, Elsevier

    Dr Alessandro Pezzella, Professor Marco d'Ischia

  58. New insight into the oxidative chemistry of noradrenaline: competitive o-quinone cyclisation and chain fission routes leading to an unusual 4-[bis-(1H-5,6-dihydroxyindol-2-yl)methyl]-1,2-dihydroxybenzene derivative

    Article • Tetrahedron, April 2005, Elsevier

    Dr Alessandro Pezzella, Professor Marco d'Ischia

  59. Regioselective Phenol or Carbinol Glycosidation of 17β-Estradiol and Derivatives Thereof

    Article • Synlett, January 2005, Thieme Publishing Group

    Dr Alessandro Pezzella

  60. 5,6-Dihydroxyindoles and Indole-5,6-diones

    Article • January 2005, Elsevier

    Dr Alessandro Pezzella, Professor Marco d'Ischia

  61. Oxidative Coupling of 17β-Estradiol:  Inventory of Oligomer Products and Configuration Assignment of Atropoisomeric C4-Linked Biphenyl-Type Dimers and Trimers

    Article • The Journal of Organic Chemistry, July 2004, American Chemical Society (ACS)

    Dr Alessandro Pezzella, Professor Marco d'Ischia

  62. 17β-Estradiol nitration by peroxidase/H2O2/NO2−: a chemical assessment

    Article • Bioorganic & Medicinal Chemistry, June 2004, Elsevier

    Dr Alessandro Pezzella, Professor Marco d'Ischia

  63. Oxidative chemistry of hydroxytyrosol: isolation and characterisation of novel methanooxocinobenzodioxinone derivatives

    Article • Tetrahedron Letters, November 2003, Elsevier

    Dr Alessandro Pezzella, Professor Marco d'Ischia

  64. Synthesis of optically active tetrameric melanin intermediates by oxidation of the melanogenic precursor 5,6-dihydroxyindole-2-carboxylic acid under biomimetic conditions

    Article • Tetrahedron Asymmetry, May 2003, Elsevier

    Dr Alessandro Pezzella

  65. Formation of novel tetrahydroisoquinoline retinoids by Pictet–Spengler reaction of dopamine and retinaldehyde under conditions of relevance to biological environments

    Article • Tetrahedron Letters, September 2002, Elsevier

    Dr Alessandro Pezzella

  66. Atropoisomeric melanin intermediates by oxidation of the melanogenic precursor 5,6-dihydroxyindole-2-carboxylic acid under biomimetic conditions

    Article • Tetrahedron, May 2002, Elsevier

    Dr Alessandro Pezzella

  67. Generation of Neurotoxins by New Reaction Pathways of Dopamine under Oxidative Stress Conditions: Contributing Etiopathological Factors in Parkinson’s Disease

    Article • January 2000, Springer Science + Business Media

    Dr Alessandro Pezzella

  68. New Reaction Pathways of Dopamine under Oxidative Stress Conditions:  Nonenzymatic Iron-Assisted Conversion to Norepinephrine and the Neurotoxins 6-Hydroxydopamine and 6,7-Dihydroxytetrahydroisoquinoline

    Article • Chemical Research in Toxicology, October 1999, American Chemical Society (ACS)

    Dr Alessandro Pezzella

  69. 6,7-Dihydroxy-1,2,3,4-tetrahydroisoquinoline formation by iron mediated dopamine oxidation: a novel route to endogenous neurotoxins under oxidative stress conditions

    Article • Tetrahedron Letters, April 1999, Elsevier

    Dr Alessandro Pezzella

  70. New directions in Parkinson’s research and treatment

    Article • Expert Opinion on Therapeutic Patents, October 1998, Informa Healthcare

    Dr Alessandro Pezzella

  71. Iron-Mediated Generation of the Neurotoxin 6-Hydroxydopamine Quinone by Reaction of Fatty Acid Hydroperoxides with Dopamine:  A Possible Contributory Mechanism for Neuronal Degeneration in Parkinson's Disease

    Article • Journal of Medicinal Chemistry, July 1997, American Chemical Society (ACS)

    Dr Alessandro Pezzella, Professor Marco d'Ischia

  72. An integrated approach to the structure of Sepia melanin. Evidence for a high proportion of degraded 5,6-dihydroxyindole-2-carboxylic acid units in the pigment backbone

    Article • Tetrahedron, June 1997, Elsevier

    Dr Alessandro Pezzella, Professor Marco d'Ischia

  73. Identification of Partially Degraded Oligomers of 5,6-Dihydroxyindole-2-carboxylic Acid inSepia Melanin by Matrix-assisted Laser Desorption/Ionization Mass Spectrometry

    Article • Rapid Communications in Mass Spectrometry, February 1997, Wiley

    Dr Alessandro Pezzella, Professor Marco d'Ischia

  74. Mass Spectrometric Behavior of 5-S-Cysteinyldopa and Structurally Related Phenolic Compounds. Fragmentation Susceptibility of the Alkylthioether Bond Under Electron Impact and Fast Atom Bombardment Conditions

    Article • Journal of Mass Spectrometry, August 1996, Wiley

    Dr Alessandro Pezzella, Professor Marco d'Ischia, Professor Donata Favretto

  75. Mass Spectrometric Behavior of 5-S-Cysteinyldopa and Structurally Related Phenolic Compounds. Fragmentation Susceptibility of the Alkylthioether Bond Under Electron Impact and Fast Atom Bombardment Conditions

    Article • Journal of Mass Spectrometry, August 1996, Wiley

    Dr Alessandro Pezzella, Professor Marco d'Ischia

  76. The first characterisation of a transient 5,6-indolequinone

    Article • Tetrahedron Letters, June 1996, Elsevier

    Dr Alessandro Pezzella, Professor Marco d'Ischia

  77. New pyrrole acids by oxidative degradation of eumelanins with hydrogen peroxide. Further hints to the mechanism of pigment breakdown

    Article • Tetrahedron, June 1996, Elsevier

    Dr Alessandro Pezzella, Professor Marco d'Ischia

  78. Oxidative polymerisation of 5,6-dihydroxyindole-2-carboxylic acid to melanin: A new insight

    Article • Tetrahedron, June 1996, Elsevier

    Dr Alessandro Pezzella, Professor Marco d'Ischia

  79. Structural Analysis of Synthetic Melanins from 5,6-Dihydroxyindole by Matrix‐assisted Laser Desorption/Ionization Mass Spectrometry

    Article • Rapid Communications in Mass Spectrometry, March 1996, Wiley

    Dr Alessandro Pezzella

  80. Structural Analysis of Synthetic Melanins from 5,6-Dihydroxyindole by Matrix-assisted Laser Desorption/Ionization Mass Spectrometry

    Article • Rapid Communications in Mass Spectrometry, March 1996, Wiley

    Dr Alessandro Pezzella

  81. A Reassessment of the Structure of 5,6-Dihydroxyindole-2-carboxylic Acid Melanins by Matrix‐assisted Laser Desorption/Ionization Mass Spectrometry

    Article • Rapid Communications in Mass Spectrometry, January 1996, Wiley

    Dr Alessandro Pezzella

  82. A Reassessment of the Structure of 5,6-Dihydroxyindole-2-carboxylic Acid Melanins by Matrix-assisted Laser Desorption/Ionization Mass Spectrometry

    Article • Rapid Communications in Mass Spectrometry, January 1996, Wiley

    Dr Alessandro Pezzella

  83. Oxidative degradation of melanins to pyrrole acids: A model study

    Article • Tetrahedron, May 1995, Elsevier

    Dr Alessandro Pezzella

  84. Generation of the Neurotoxin 6-Hydroxydopamine by Peroxidase/H2O2 Oxidation of Dopamine

    Article • Journal of Medicinal Chemistry, March 1995, American Chemical Society (ACS)

    Dr Alessandro Pezzella

  85. The origin of pyrrole-2,3,5-tricarboxylic acid by oxidative degradation of eumelanins

    Article • Melanoma Research, September 1994, Wolters Kluwer Health

    Dr Alessandro Pezzella