All Stories

  1. HYDROchlorothiazide versus placebo to PROTECT polycystic kidney disease patients and improve their quality of life: study protocol and rationale for the HYDRO-PROTECT randomized controlled trial

    Article • Trials, February 2024, Springer Science + Business Media

    Professor Albert Ong

  2. An Artificial Intelligence Generated Automated Algorithm to Measure Total Kidney Volume in ADPKD

    Article • Kidney International Reports, February 2024, Elsevier

    Professor Albert Ong

  3. Combining genotype with height-adjusted kidney length predicts rapid progression of ADPKD

    Article • Nephrology Dialysis Transplantation, January 2024, Oxford University Press (OUP)

    Professor Albert Ong

  4. Macrophage subpopulation identity in Drosophila is modulated by apoptotic cell clearance and related signalling pathways

    Article • Frontiers in Immunology, January 2024, Frontiers

    Professor Albert Ong

  5. Liver transplant recipients with polycystic liver disease have longer waiting times but better long-term clinical outcomes than those with liver disease due to other causes: A retrospective cross-sectional study

    Article • PLoS ONE, January 2024, PLOS

    Professor Albert Ong

  6. Rare disease gene association discovery from burden analysis of the 100,000 Genomes Project data

    Article • December 2023, Cold Spring Harbor Laboratory Press

    Professor Albert Ong

  7. Macrophage subpopulation identity inDrosophilais modulated by apoptotic cell clearance and related signalling pathways

    Article • September 2023, Cold Spring Harbor Laboratory Press

    Professor Albert Ong

  8. Identification of renal cyst cells of type I Nephronophthisis by single-nucleus RNA sequencing

    Article • Frontiers in Cell and Developmental Biology, July 2023, Frontiers

    Professor Albert Ong

  9. The Common PKD1 p.(Ile3167Phe) Variant Is Hypomorphic and Associated with Very Early Onset, Biallelic Polycystic Kidney Disease

    Article • Human Mutation, July 2023, Hindawi Publishing Corporation

    Professor Albert Ong

  10. Barriers and facilitators to the implementation of guidelines in rare diseases: a systematic review

    Article • Orphanet Journal of Rare Diseases, June 2023, Springer Science + Business Media

    Professor Albert Ong

  11. OVERTURE: A Worldwide, Prospective, Observational Study of Disease Characteristics in Patients With ADPKD

    Article • Kidney International Reports, May 2023, Elsevier

    Professor Albert Ong

  12. Patient Perspectives on ADPKD

    Article • Advances in Kidney Disease and Health, May 2023, Elsevier

    Professor Albert Ong

  13. Venglustat, a Novel Glucosylceramide Synthase Inhibitor, in Patients at Risk of Rapidly Progressing ADPKD: Primary Results of a Double-Blind, Placebo-Controlled, Phase 2/3 Randomized Clinical Trial

    Article • American Journal of Kidney Diseases, May 2023, Elsevier

    Professor Albert Ong

  14. Hypertension in young adults with autosomal dominant polycystic kidney disease: a case for early screening?

    Article • Clinical Kidney Journal, March 2023, Oxford University Press (OUP)

    Professor Albert Ong

  15. The association of urinary epidermal growth factors with ADPKD disease severity and progression

    Article • Nephrology Dialysis Transplantation, March 2023, Oxford University Press (OUP)

    Professor Albert Ong

  16. Diet and Polycystic Kidney Disease: Nutrients, Foods, Dietary Patterns, and Implications for Practice

    Article • Seminars in Nephrology, March 2023, Elsevier

    Professor Albert Ong

  17. WCN23-0391 THE CLINICAL CHARACTERISTICS AND KIDNEY OUTCOME IN CHINESE PATIENTS WITH TYPICAL AND ATYPICAL POLYCYSTIC KIDNEY DISEASE

    Article • Kidney International Reports, March 2023, Elsevier

    Professor Albert Ong

  18. Chronic kidney disease as cardiovascular risk factor in routine clinical practice: a position statement by the Council of the European Renal Association

    Article • Nephrology Dialysis Transplantation, October 2022, Oxford University Press (OUP)

    Professor Albert Ong

  19. Chronic kidney disease as cardiovascular risk factor in routine clinical practice: a position statement by the Council of the European Renal Association

    Article • Clinical Kidney Journal, October 2022, Oxford University Press (OUP)

    Professor Albert Ong

  20. The STAGED-PKD 2-Stage Adaptive Study With a Patient Enrichment Strategy and Treatment Effect Modeling for Improved Study Design Efficiency in Patients With ADPKD

    Article • Kidney Medicine, October 2022, Elsevier

    Professor Albert Ong

  21. P73 Patients with polycystic liver disease have longer waiting times but better clinical outcomes following liver transplantation in the UK

    Article • September 2022, BMJ

    Professor Albert Ong

  22. A founderUMODvariant is a common cause of hereditary nephropathy in the British population

    Article • Journal of Medical Genetics, August 2022, BMJ

    Professor Albert Ong

  23. Regional variation in tolvaptan prescribing across England: national data and retrospective evaluation from an expert centre

    Article • Clinical Kidney Journal, August 2022, Oxford University Press (OUP)

    Professor Albert Ong

  24. Chronic kidney disease as cardiovascular risk factor in routine clinical practice: a position statement by the Council of the European Renal Association

    Article • European Journal of Preventive Cardiology, August 2022, Oxford University Press (OUP)

    Professor Albert Ong

  25. Patients with polcystic liver disease have longer waiting times but better clinical outcomes following liver transplantation in the UK

    Article • Journal of Hepatology, July 2022, Elsevier

    Professor Albert Ong

  26. Barriers and facilitators to the implementation of guidelines in rare diseases: A systematic review

    Article • June 2022, Research Square

    Professor Albert Ong

  27. Flank pain has a significant adverse impact on quality of life in ADPKD: the CYSTic-QoL study

    Article • Clinical Kidney Journal, June 2022, Oxford University Press (OUP)

    Professor Albert Ong

  28. Research priorities for autosomal dominant polycystic kidney disease: a UK priority setting partnership

    Article • BMJ Open, June 2022, BMJ

    Professor Albert Ong

  29. An update on the use of tolvaptan for autosomal dominant polycystic kidney disease: consensus statement on behalf of the ERA Working Group on Inherited Kidney Disorders, the European Rare Kidney Disease Reference Network and Polycystic Kidney Disease I...

    Article • KIDNEYS, May 2022, Publishing House Zaslavsky

    Professor Albert Ong

  30. FC029: A Multivariate Model Identifies Genotype, Hypertension and Kidney Length as Independent Baseline Predictors of Disease Progression in a Longitudinal Autosomal Dominant Polycystic Kidney Disease Patient Cohort

    Article • Nephrology Dialysis Transplantation, May 2022, Oxford University Press (OUP)

    Professor Albert Ong

  31. MO012: Development of an Accurate Automated Segmentation Algorithm to Measure Total Kidney Volume in ADPKD Suitable for Clinical Application (The Cystvas Study)

    Article • Nephrology Dialysis Transplantation, May 2022, Oxford University Press (OUP)

    Professor Albert Ong

  32. MO015: The Interaction of Gender and Genotype in the Development of Polycystic Liver Disease in ADPKD

    Article • Nephrology Dialysis Transplantation, May 2022, Oxford University Press (OUP)

    Professor Albert Ong

  33. MO030: Familial clustering of a rare UMOD variant in undiagnosed hereditary nephropathy suggests the presence of a common ancestral founder mutation

    Article • Nephrology Dialysis Transplantation, May 2022, Oxford University Press (OUP)

    Professor Albert Ong

  34. Can ketogenic dietary interventions slow disease progression in ADPKD: what we know and what we don't

    Article • Clinical Kidney Journal, April 2022, Oxford University Press (OUP)

    Professor Albert Ong

  35. From WEDA to EDTA to ERA: 60 years of supporting European nephrology and counting

    Article • Nephrology Dialysis Transplantation, April 2022, Oxford University Press (OUP)

    Professor Albert Ong

  36. Individualized everolimus treatment for tuberous sclerosis-related angiomyolipoma promotes treatment adherence and response

    Article • Clinical Kidney Journal, February 2022, Oxford University Press (OUP)

    Professor Albert Ong

  37. Monoallelic IFT140 pathogenic variants are an important cause of the autosomal dominant polycystic kidney-spectrum phenotype

    Article • The American Journal of Human Genetics, January 2022, Elsevier

    Professor Albert Ong

  38. Metformin induces lactate accumulation and accelerates renal cyst progression in Pkd1-deficient mice

    Article • Human Molecular Genetics, November 2021, Oxford University Press (OUP)

    Professor Albert Ong

  39. An update on the use of tolvaptan for autosomal dominant polycystic kidney disease: consensus statement on behalf of the ERA Working Group on Inherited Kidney Disorders, the European Rare Kidney Disease Reference Network and Polycystic Kidney Disease I...

    Article • Nephrology Dialysis Transplantation, November 2021, Oxford University Press (OUP)

    Professor Albert Ong

  40. TAMEing ADPKD with metformin: safe and effective?

    Article • Kidney International, September 2021, Elsevier

    Professor Albert Ong

  41. An Nphp1 knockout mouse model targeting exon 2–20 demonstrates characteristic phenotypes of human nephronophthisis

    Article • Human Molecular Genetics, August 2021, Oxford University Press (OUP)

    Professor Albert Ong

  42. MO023FLANK PAIN HAS A MAJOR NEGATIVE IMPACT ON HEALTH-RELATED QUALITY OF LIFE IN ADPKD: THE CYSTIC I STUDY

    Article • Nephrology Dialysis Transplantation, May 2021, Oxford University Press (OUP)

    Professor Albert Ong

  43. Biallelic inheritance of hypomorphic PKD1 variants is highly prevalent in very early onset polycystic kidney disease

    Article • Genetics in Medicine, April 2021, Elsevier

    Professor Albert Ong

  44. Drug repurposing in autosomal dominant polycystic kidney disease: back to the future with pioglitazone

    Article • Clinical Kidney Journal, March 2021, Oxford University Press (OUP)

    Professor Albert Ong

  45. Establishing a Core Outcome Set for Autosomal Dominant Polycystic Kidney Disease: Report of the Standardized Outcomes in Nephrology–Polycystic Kidney Disease (SONG-PKD) Consensus Workshop

    Article • American Journal of Kidney Diseases, February 2021, Elsevier

    Professor Albert Ong

  46. An international cohort study of autosomal dominant tubulointerstitial kidney disease due to mutations identifies distinct clinical subtypes

    Article • Kidney International, December 2020, Elsevier

    Professor Albert Ong

  47. Coronavirus-associated kidney outcomes in COVID-19, SARS, and MERS: a meta-analysis and systematic review

    Article • Renal Failure, November 2020, Taylor & Francis

    Professor Albert Ong, Dr. Cheng Xue

  48. The Controversial Role of Fibrosis in Autosomal Dominant Polycystic Kidney Disease

    Article • International Journal of Molecular Sciences, November 2020, MDPI AG

    Professor Albert Ong

  49. ‘A sword of Damocles’: patient and caregiver beliefs, attitudes and perspectives on presymptomatic testing for autosomal dominant polycystic kidney disease: a focus group study

    Article • BMJ Open, October 2020, BMJ

    Professor Albert Ong

  50. Core Outcome Domains for Trials in Autosomal Dominant Polycystic Kidney Disease: An International Delphi Survey

    Article • American Journal of Kidney Diseases, September 2020, Elsevier

    Professor Albert Ong

  51. Polycystin-1 regulates ARHGAP35-dependent centrosomal RhoA activation and ROCK signaling

    Article • JCI Insight, August 2020, American Society for Clinical Investigation

    Professor Albert Ong

  52. Clinical spectrum, prognosis and estimated prevalence of DNAJB11-kidney disease

    Article • Kidney International, August 2020, Elsevier

    Professor Albert Ong

  53. Global microRNA profiling in human urinary exosomes reveals novel disease biomarkers and cellular pathways for autosomal dominant polycystic kidney disease

    Article • Kidney International, August 2020, Elsevier

    Professor Albert Ong

  54. Post-translational modifications of the polycystin proteins

    Article • Cellular Signalling, August 2020, Elsevier

    Professor Albert Ong

  55. Range and Variability of Outcomes Reported in Randomized Trials Conducted in Patients With Polycystic Kidney Disease: A Systematic Review

    Article • American Journal of Kidney Diseases, August 2020, Elsevier

    Professor Albert Ong

  56. The positive effect of selective prostaglandin E2 receptor EP2 and EP4 blockade on cystogenesis in vitro is counteracted by increased kidney inflammation in vivo

    Article • Kidney International, August 2020, Elsevier

    Professor Albert Ong

  57. Publisher Correction: Whole-genome sequencing of a sporadic primary immunodeficiency cohort

    Article • Nature, July 2020, Springer Science + Business Media

    Professor Albert Ong

  58. Cellular signaling in PKD: foreword

    Article • Cellular Signalling, July 2020, Elsevier

    Professor Albert Ong

  59. SO092REDUCED QUALITY OF LIFE IN ADPKD PATIENTS WITH CKD STAGE 1-3: THE CYSTIC I QUALITY OF LIFE STUDY

    Article • Nephrology Dialysis Transplantation, June 2020, Oxford University Press (OUP)

    Professor Albert Ong

  60. Whole-genome sequencing of a sporadic primary immunodeficiency cohort

    Article • Nature, May 2020, Springer Science + Business Media

    Professor Albert Ong

  61. Ankhd1 enhances polycystic kidney disease development via promoting proliferation and fibrosis

    Article • March 2020, Cold Spring Harbor Laboratory Press

    Professor Albert Ong

  62. SAT-442 Identification of Exosome MicroRNAs as Novel Biomarkers for Rapid Disease Progression in Autosomal Dominant Polycystic Kidney Disease

    Article • Kidney International Reports, March 2020, Elsevier

    Professor Albert Ong

  63. Detection and characterization of mosaicism in autosomal dominant polycystic kidney disease

    Article • Kidney International, February 2020, Elsevier

    Professor Albert Ong

  64. A high throughput zebrafish chemical screen reveals ALK5 and non-canonical androgen signalling as modulators of the pkd2−/− phenotype

    Article • Scientific Reports, January 2020, Springer Science + Business Media

    Professor Albert Ong

  65. Long-acting somatostatin analogue treatments in autosomal dominant polycystic kidney disease and polycystic liver disease: a systematic review and meta-analysis

    Article • BMJ Open, January 2020, BMJ

    Professor Albert Ong

  66. Tuberous Sclerosis Complex (TSC): Expert Recommendations for Provision of Coordinated Care

    Article • Frontiers in Neurology, November 2019, Frontiers

    Professor Albert Ong

  67. SAT-100 “A SWORD OF DAMOCLES”: PATIENT AND CAREGIVER BELIEFS, ATTITUDES AND PERSPECTIVES ON GENETIC SCREENING AND TESTING FOR AUTOSOMAL POLYCYSTIC KIDNEY DISEASE - FOCUS GROUP STUDY

    Article • Kidney International Reports, July 2019, Elsevier

    Professor Albert Ong

  68. SAT-334 GENETIC TESTING OF FAMILIES WITH VERY EARLY ONSET POLYCYSTIC KIDNEY DISEASE REVEALS THE FUNCTIONAL SIGNIFICANCE OF HYPOMORPHIC VARIANTS

    Article • Kidney International Reports, July 2019, Elsevier

    Professor Albert Ong

  69. Small-molecule allosteric activators of PDE4 long form cyclic AMP phosphodiesterases

    Article • Proceedings of the National Academy of Sciences, June 2019, Proceedings of the National Academy of Sciences

    Professor Albert Ong

  70. FO026GLOBAL MICRORNA PROFILING IN HUMAN URINARY EXOSOMES REVEALS NEW DISEASE BIOMARKERS AND CELLULAR PATHWAYS FOR AUTOSOMAL DOMINANT POLYCYSTIC KIDNEY DISEASE (ADPKD)

    Article • Nephrology Dialysis Transplantation, June 2019, Oxford University Press (OUP)

    Professor Albert Ong

  71. SaO005CLINICAL PRESENTATION AND PROGNOSIS OF DNAJB11-ASSOCIATED NEPHROPATHY: AN INTERNATIONAL COLLABORATIVE STUDY

    Article • Nephrology Dialysis Transplantation, June 2019, Oxford University Press (OUP)

    Professor Albert Ong

  72. Renal monocyte chemoattractant protein-1: an emerging universal biomarker and therapeutic target for kidney diseases?

    Article • Nephrology Dialysis Transplantation, May 2019, Oxford University Press (OUP)

    Professor Albert Ong

  73. Identifying patient‐important outcomes in polycystic kidney disease: An international nominal group technique study

    Article • Nephrology, May 2019, Wiley

    Professor Albert Ong

  74. Imaging of Kidney Cysts and Cystic Kidney Diseases in Children: An International Working Group Consensus Statement

    Article • Radiology, March 2019, Radiological Society of North America (RSNA)

    Professor Albert Ong

  75. A rapid high-performance semi-automated tool to measure total kidney volume from MRI in autosomal dominant polycystic kidney disease

    Article • European Radiology, January 2019, Springer Science + Business Media

    Professor Albert Ong

  76. Implementing core outcomes in kidney disease: report of the Standardized Outcomes in Nephrology (SONG) implementation workshop

    Article • Kidney International, December 2018, Elsevier

    Dr Tushar Vachharajani , Professor Albert Ong

  77. Imaging of kidney cysts and cystic kidney diseases in children. Consensus paper by an ad hoc committee

    Article • Ultraschall in der Medizin - European Journal of Ultrasound, October 2018, Thieme Publishing Group

    Professor Albert Ong

  78. Magnetic resonance imaging biomarkers for chronic kidney disease: a position paper from the European Cooperation in Science and Technology Action PARENCHIMA

    Article • Nephrology Dialysis Transplantation, August 2018, Oxford University Press (OUP)

    Professor Albert Ong

  79. Linear and Nonlinear Estimated GFR Slopes in ADPKD Patients Reaching ESRD

    Article • American Journal of Kidney Diseases, June 2018, Elsevier

    Professor Albert Ong

  80. A model to predict disease progression in patients with autosomal dominant polycystic kidney disease (ADPKD): the ADPKD Outcomes Model

    Article • BMC Nephrology, February 2018, Springer Science + Business Media

    Professor Albert Ong

  81. Tolvaptan slows disease progression in late-stage ADPKD

    Article • Nature Reviews Nephrology, January 2018, Springer Science + Business Media

    Professor Albert Ong

  82. European ADPKD Forum multidisciplinary position statement on autosomal dominant polycystic kidney disease care

    Article • Nephrology Dialysis Transplantation, December 2017, Oxford University Press (OUP)

    Professor Albert Ong

  83. Standardised Outcomes in Nephrology—Polycystic Kidney Disease (SONG-PKD): study protocol for establishing a core outcome set in polycystic kidney disease

    Article • Trials, November 2017, Springer Science + Business Media

    Professor Albert Ong

  84. Targeting new cellular disease pathways in autosomal dominant polycystic kidney disease

    Article • Nephrology Dialysis Transplantation, October 2017, Oxford University Press (OUP)

    Professor Albert Ong

  85. Targeting new cellular disease pathways in autosomal dominant polycystic kidney disease

    Article • Nephrology Dialysis Transplantation, August 2017, Oxford University Press (OUP)

    Professor Albert Ong

  86. The Sorting Nexin 3 Retromer Pathway Regulates the Cell Surface Localization and Activity of a Wnt-Activated Polycystin Channel Complex

    Article • Journal of the American Society of Nephrology, June 2017, American Society of Nephrology

    Professor Albert Ong

  87. Making sense of polycystic kidney disease

    Article • The Lancet, May 2017, Elsevier

    Professor Albert Ong

  88. TO033VERY EARLY-ONSET AUTOSOMAL DOMINANT POLYCYSTIC KIDNEY DISEASE DUE TO BI-ALLELIC MUTATIONS IN PKD1 AND PKD2

    Article • Nephrology Dialysis Transplantation, May 2017, Oxford University Press (OUP)

    Professor Albert Ong

  89. Parallel microarray profiling identifies ErbB4 as a determinant of cyst growth in ADPKD and a prognostic biomarker for disease progression

    Article • AJP Renal Physiology, April 2017, American Physiological Society

    Professor Albert Ong

  90. STAT5 drives abnormal proliferation in autosomal dominant polycystic kidney disease

    Article • Kidney International, March 2017, Elsevier

    Professor Albert Ong

  91. Development of a rapid semi-automated tool to measure total kidney volume in autosomal dominant polycystic kidney disease

    Article • The Lancet, February 2017, Elsevier

    Professor Albert Ong

  92. Autosomal dominant polycystic kidney disease: recent advances in clinical management

    Article • F1000Research, August 2016, Faculty of 1000, Ltd.

    Professor Albert Ong

  93. SO052DEVELOPMENT OF A RAPID SEMI-AUTOMATED TOOL TO MEASURE TOTAL KIDNEY VOLUME IN AUTOSOMAL DOMINANT POLYCYSTIC KIDNEY DISEASE

    Article • Nephrology Dialysis Transplantation, May 2016, Oxford University Press (OUP)

    Professor Albert Ong

  94. SO053SELECTIVE PROSTAGLANDIN E2 RECEPTOR BLOCKADE FOR THE TREATMENT OF AUTOSOMAL DOMINANT POLYCYSTIC KIDNEY DISEASE

    Article • Nephrology Dialysis Transplantation, May 2016, Oxford University Press (OUP)

    Professor Albert Ong

  95. The Cyclic AMP Signaling Pathway and Direct PKA Phosphorylation Regulate Polycystin-2 (TRPP2) Channel Function

    Article • Biophysical Journal, February 2016, Elsevier

    Professor Albert Ong

  96. Recommendations for the use of tolvaptan in autosomal dominant polycystic kidney disease: a position statement on behalf of the ERA-EDTA Working Groups on Inherited Kidney Disorders and European Renal Best Practice

    Article • Nephrology Dialysis Transplantation, January 2016, Oxford University Press (OUP)

    prof alberto ortiz , Professor Albert Ong

  97. New onset diabetes after kidney transplantation in patients with autosomal dominant polycystic kidney disease: systematic review protocol: Figure 1

    Article • BMJ Open, November 2015, BMJ

    Professor Albert Ong

  98. A polycystin-centric view of cyst formation and disease: the polycystins revisited

    Article • Kidney International, October 2015, Elsevier

    Professor Albert Ong

  99. Autosomal dominant polycystic kidney disease

    Article • October 2015, Oxford University Press (OUP)

    Professor Albert Ong

  100. Autosomal dominant polycystic kidney disease

    Article • October 2015, Oxford University Press (OUP)

    Professor Albert Ong

  101. The cAMP Signaling Pathway and Direct Protein Kinase A Phosphorylation Regulate Polycystin-2 (TRPP2) Channel Function

    Article • Journal of Biological Chemistry, September 2015, Elsevier

    Professor Albert Ong

  102. The Polycystin-1, Lipoxygenase, and α-Toxin Domain Regulates Polycystin-1 Trafficking

    Article • Journal of the American Society of Nephrology, August 2015, American Society of Nephrology

    Frederic JEAN-ALPHONSE, Professor Albert Ong

  103. Increased psychosocial risk, depression and reduced quality of life living with autosomal dominant polycystic kidney disease

    Article • Nephrology Dialysis Transplantation, August 2015, Oxford University Press (OUP)

    Professor Albert Ong

  104. Autosomal-dominant polycystic kidney disease (ADPKD): executive summary from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference

    Article • Kidney International, July 2015, Elsevier

    Professor Albert Ong

  105. Department of Error

    Article • The Lancet, June 2015, Elsevier

    Professor Albert Ong

  106. Backbone assignment and secondary structure of the PLAT domain of human polycystin-1

    Article • Biomolecular NMR Assignments, May 2015, Springer Science + Business Media

    Professor Albert Ong

  107. Autosomal dominant polycystic kidney disease: the changing face of clinical management

    Article • The Lancet, May 2015, Elsevier

    Professor Albert Ong

  108. FP064ASSESSING THE LONG TERM OUTCOMES OF AUTOSOMAL DOMINANT POLYCYSTIC KIDNEY DISEASE (ADPKD) USING THE ADPKD OUTCOMES MODEL: A UK CASE STUDY

    Article • Nephrology Dialysis Transplantation, May 2015, Oxford University Press (OUP)

    Professor Albert Ong

  109. FP364INCREASED PSYCHOSOCIAL BURDEN AND ADVERSE QUALITY OF LIFE IN AUTOSOMAL DOMINANT POLYCYSTIC KIDNEY DISEASE

    Article • Nephrology Dialysis Transplantation, May 2015, Oxford University Press (OUP)

    Professor Albert Ong

  110. Genetic Testing in the Assessment of Living Related Kidney Donors at Risk of Autosomal Dominant Polycystic Kidney Disease

    Article • Transplantation, May 2015, Wolters Kluwer Health

    Professor Albert Ong

  111. SuO042POLYCYSTIN-1 TRAFFICKING IS REGULATED BY CAMP DEPENDENT PHOSPHORYLATION OF THE PLAT DOMAIN

    Article • Nephrology Dialysis Transplantation, May 2015, Oxford University Press (OUP)

    Professor Albert Ong

  112. Endothelin and Tubulointerstitial Renal Disease

    Article • Seminars in Nephrology, March 2015, Elsevier

    Prof. Dr. Berthold Hocher, Professor Berthold Hocher, Professor Albert Ong

  113. Analysis of data from the ERA-EDTA Registry indicates that conventional treatments for chronic kidney disease do not reduce the need for renal replacement therapy in autosomal dominant polycystic kidney disease

    Article • Kidney International, December 2014, Elsevier

    Professor Albert Ong

  114. Erratum

    Article • Nephrology Dialysis Transplantation, December 2014, Oxford University Press (OUP)

    Professor Albert Ong

  115. Development Of A Model To Predict Disease Progression In Autosomal Dominant Polycystic Kidney Disease (ADPKD)

    Article • Value in Health, November 2014, Elsevier

    Professor Albert Ong

  116. Genetics and Genomics of Chronic Kidney Disease

    Article • September 2014, Oxford University Press (OUP)

    Prof Alexander P Maxwell, Professor Albert Ong

  117. Building a network of ADPKD reference centres across Europe: the EuroCYST initiative

    Article • Nephrology Dialysis Transplantation, September 2014, Oxford University Press (OUP)

    Professor Albert Ong

  118. How simple are 'simple renal cysts'?

    Article • Nephrology Dialysis Transplantation, August 2014, Oxford University Press (OUP)

    Professor Albert Ong

  119. Renal replacement therapy for autosomal dominant polycystic kidney disease (ADPKD) in Europe: prevalence and survival--an analysis of data from the ERA-EDTA Registry

    Article • Nephrology Dialysis Transplantation, August 2014, Oxford University Press (OUP)

    Professor Albert Ong

  120. Sudden death due to subarachnoid haemorrhage in an infant with autosomal dominant polycystic kidney disease

    Article • Nephrology Dialysis Transplantation, August 2014, Oxford University Press (OUP)

    Professor Albert Ong

  121. Rare inherited kidney diseases: challenges, opportunities, and perspectives

    Article • The Lancet, May 2014, Elsevier

    Professor Albert Ong

  122. RENAL DEVELOPMENT AND CYSTIC DISEASES

    Article • Nephrology Dialysis Transplantation, May 2014, Oxford University Press (OUP)

    Professor Albert Ong

  123. Metabolic abnormalities in autosomal dominant polycystic kidney disease

    Article • Nephrology Dialysis Transplantation, March 2014, Oxford University Press (OUP)

    Professor Albert Ong

  124. Angiopoietin-1 regulates microvascular reactivity and protects the microcirculation during acute endothelial dysfunction: Role of eNOS and VE-cadherin

    Article • Pharmacological Research, February 2014, Elsevier

    Professor Albert Ong

  125. TRPP2 in Polycystic Kidney Disease

    Article • November 2013, Springer Science + Business Media

    Professor Albert Ong

  126. Polycystin-1 but not polycystin-2 deficiency causes upregulation of the mTOR pathway and can be synergistically targeted with rapamycin and metformin

    Article • Pflügers Archiv - European Journal of Physiology, November 2013, Springer Science + Business Media

    Professor Albert Ong

  127. Cosegregation of Focal Segmental Glomerulosclerosis in a Family with Familial Partial Lipodystrophy due to a Mutation in <b><i>LMNA</i></b>

    Article • Nephron Clinical Practice, September 2013, Karger Publishers

    Professor Albert Ong

  128. New treatments for autosomal dominant polycystic kidney disease

    Article • British Journal of Clinical Pharmacology, September 2013, Wiley

    Professor Albert Ong

  129. Fabrication of Luminescent Monolayered Tungsten Dichalcogenides Quantum Dots with Giant Spin-Valley Coupling

    Article • ACS Nano, September 2013, American Chemical Society (ACS)

    Professor Albert Ong

  130. The Role of Phospholipase D in Modulating the MTOR Signaling Pathway in Polycystic Kidney Disease

    Article • PLoS ONE, August 2013, PLOS

    Dr Alexandre Arcaro, Professor Albert Ong

  131. Primary cilia and renal cysts: does length matter?

    Article • Nephrology Dialysis Transplantation, August 2013, Oxford University Press (OUP)

    Professor Albert Ong

  132. Fabrication and Luminescence of Monolayered Boron Nitride Quantum Dots

    Article • Small, July 2013, Wiley

    Professor Albert Ong

  133. The natural history of autosomal dominant polycystic kidney disease: 30-year experience from a single centre

    Article • QJM, April 2013, Oxford University Press (OUP)

    Professor Albert Ong

  134. Hyperphosphorylation of polycystin-2 at a critical residue in disease reveals an essential role for polycystin-1-regulated dephosphorylation

    Article • Human Molecular Genetics, February 2013, Oxford University Press (OUP)

    Professor Albert Ong

  135. Pkd2 mesenteric vessels exhibit a primary defect in endothelium-dependent vasodilatation restored by rosiglitazone

    Article • AJP Heart and Circulatory Physiology, January 2013, American Physiological Society

    Professor Albert Ong

  136. Cystic kidney diseases: many ways to form a cyst

    Article • Pediatric Nephrology, June 2012, Springer Science + Business Media

    Professor Albert Ong

  137. The ERA-EDTA Working Group on inherited kidney disorders

    Article • Nephrology Dialysis Transplantation, January 2012, Oxford University Press (OUP)

    Professor Albert Ong

  138. Mechanism-Based Therapeutics for Autosomal Dominant Polycystic Kidney Disease: Recent Progress and Future Prospects

    Article • Nephron Clinical Practice, December 2011, Karger Publishers

    Professor Albert Ong

  139. 32 PKD2 mutant zebrafish display excessive developmental angiogenesis

    Article • Heart, September 2011, BMJ

    Professor Albert Ong

  140. Spurious hypophosphatemia associated with monoclonal paraproteinemia

    Article • QJM, June 2011, Oxford University Press (OUP)

    Professor Albert Ong

  141. Thiazolidinediones inhibit MDCK cyst growth through disrupting oriented cell division and apicobasal polarity

    Article • AJP Renal Physiology, June 2011, American Physiological Society

    Professor Albert Ong

  142. A Single Amino Acid Residue Constitutes the Third Dimerization Domain Essential for the Assembly and Function of the Tetrameric Polycystin-2 (TRPP2) Channel

    Article • Journal of Biological Chemistry, May 2011, Elsevier

    Professor Albert Ong

  143. What’s new in… Ciliopathies

    Article • Medicine, February 2011, Elsevier

    Professor Albert Ong

  144. Endothelin in Polycystic Kidney Disease

    Article • January 2011, Karger Publishers

    Professor Albert Ong

  145. Protein Kinase D–mediated Phosphorylation of Polycystin-2 (TRPP2) Is Essential for Its Effects on Cell Growth and Calcium Channel Activity

    Article • Molecular Biology of the Cell, November 2010, American Society for Cell Biology (ASCB)

    Professor Albert Ong

  146. Towards the Integration of Genetic Knowledge into Clinical Practice

    Article • Nephron Clinical Practice, November 2010, Karger Publishers

    Professor Albert Ong

  147. A polycystin-2 (TRPP2) dimerization domain essential for the function of heteromeric polycystin complexes

    Article • The EMBO Journal, February 2010, Springer Science + Business Media

    Professor Albert Ong

  148. Structural and Molecular Basis of the Assembly of the TRPP2/PKD1 Complex

    Article • Biophysical Journal, January 2010, Elsevier

    Professor Albert Ong

  149. Screening for intracranial aneurysms in ADPKD

    Article • BMJ, October 2009, BMJ

    Professor Albert Ong

  150. Pkd2 Dosage Influences Cellular Repair Responses following Ischemia-Reperfusion Injury

    Article • American Journal Of Pathology, October 2009, Elsevier

    Professor Albert Ong

  151. Screening for intracranial aneurysms in ADPKD

    Article • BMJ, September 2009, BMJ

    Professor Albert Ong

  152. Structural and molecular basis of the assembly of the TRPP2/PKD1 complex

    Article • Proceedings of the National Academy of Sciences, July 2009, Proceedings of the National Academy of Sciences

    Professor Albert Ong

  153. A novel dephosphorylation‐activated conductance in a mouse renal collecting duct cell line

    Article • Experimental Physiology, July 2009, Wiley

    Professor Albert Ong

  154. Peroxisome Proliferator-Activated Receptor Gamma Agonists in Kidney Disease – Future Promise, Present Fears

    Article • Nephron Clinical Practice, June 2009, Karger Publishers

    Professor Albert Ong

  155. Autosomal dominant polycystic kidney disease

    Article • Clinical Medicine, June 2009, Elsevier

    Professor Albert Ong

  156. Homophilic and heterophilic polycystin 1 interactions regulate E-cadherin recruitment and junction assembly in MDCK cells

    Article • Journal of Cell Science, May 2009, The Company of Biologists

    Professor Albert Ong

  157. Homophilic and heterophilic polycystin 1 interactions regulate E-cadherin recruitment and junction assembly in MDCK cells

    Article • Journal of Cell Science, May 2009, The Company of Biologists

    Professor Albert Ong

  158. Identification and Functional Characterization of an N-terminal Oligomerization Domain for Polycystin-2

    Article • Journal of Biological Chemistry, October 2008, Elsevier

    Professor Albert Ong

  159. Activation of TRPP2 through mDia1-dependent voltage gating

    Article • The EMBO Journal, April 2008, Springer Science + Business Media

    Professor Albert Ong

  160. Chronic Renal Disease

    Article • February 2008, Oxford University Press (OUP)

    Professor Albert Ong

  161. Autosomal Dominant Polycystic Kidney Disease: Recent Advances in Pathogenesis and Treatment

    Article • Nephron Physiology, December 2007, Karger Publishers

    Professor Albert Ong

  162. Hyperproliferation of PKD1 cystic cells is induced by insulin-like growth factor-1 activation of the Ras/Raf signalling system

    Article • Kidney International, July 2007, Elsevier

    Professor Albert Ong

  163. Involvement of Hypoxia-Inducible Transcription Factors in Polycystic Kidney Disease

    Article • American Journal Of Pathology, March 2007, Elsevier

    Professor Albert Ong

  164. Endothelin B Receptor Blockade Accelerates Disease Progression in a Murine Model of Autosomal Dominant Polycystic Kidney Disease

    Article • Journal of the American Society of Nephrology, February 2007, Wolters Kluwer Health

    Professor Albert Ong

  165. Contributors

    Article • January 2007, Elsevier

    Professor Albert Ong

  166. Identification of an N-terminal glycogen synthase kinase 3 phosphorylation site which regulates the functional localization of polycystin-2 in vivo and in vitro

    Article • Human Molecular Genetics, March 2006, Oxford University Press (OUP)

    Professor Albert Ong

  167. Detection of Proximal Tubular Motile Cilia in a Patient With Renal Sarcoidosis Associated With Hypercalcemia

    Article • American Journal of Kidney Diseases, June 2005, Elsevier

    Professor Albert Ong

  168. Molecular pathogenesis of ADPKD: The polycystin complex gets complex

    Article • Kidney International, April 2005, Elsevier

    Professor Albert Ong

  169. Expression and Cellular Localisation of Renal Endothelin-1 and Endothelin Receptor Subtypes in Autosomal-Dominant Polycystic Kidney Disease

    Article • Nephron Experimental Nephrology, November 2004, Karger Publishers

    Professor Albert Ong

  170. Aberrant Polycystin-1 Expression Results in Modification of Activator Protein-1 Activity, whereas Wnt Signaling Remains Unaffected

    Article • Journal of Biological Chemistry, June 2004, Elsevier

    Professor Albert Ong

  171. Functional Analysis of PKD1 Transgenic Lines Reveals a Direct Role for Polycystin-1 in Mediating Cell-Cell Adhesion

    Article • Journal of the American Society of Nephrology, July 2003, Wolters Kluwer Health

    Professor Albert Ong

  172. Association of mutation position in polycystic kidney disease 1 (PKD1) gene and development of a vascular phenotype

    Article • The Lancet, June 2003, Elsevier

    Professor Albert Ong

  173. Genetic Renal Abnormalities

    Article • Medicine, May 2003, Elsevier

    Professor Albert Ong

  174. Polycystic kidney disease—the ciliary connection

    Article • The Lancet, March 2003, Elsevier

    Professor Albert Ong

  175. Polycystin-2 expression is increased following experimental ischaemic renal injury

    Article • Nephrology Dialysis Transplantation, December 2002, Oxford University Press (OUP)

    Professor Albert Ong

  176. Identification, Characterization, and Localization of a Novel Kidney Polycystin-1-Polycystin-2 Complex

    Article • Journal of Biological Chemistry, June 2002, Elsevier

    Professor Albert Ong

  177. Polycystin Expression in the Kidney and Other Tissues: Complexity, Consensus and Controversy

    Article • Nephron Experimental Nephrology, July 2000, Karger Publishers

    Professor Albert Ong

  178. Endothelin antagonists in renal disease

    Article • Kidney International, April 2000, Elsevier

    Professor Albert Ong

  179. Polycystin-1 expression in PKD1, early-onset PKD1, and TSC2/PKD1 cystic tissue

    Article • Kidney International, October 1999, Elsevier

    Professor Albert Ong

  180. Coordinate Expression of the Autosomal Dominant Polycystic Kidney Disease Proteins, Polycystin-2 And Polycystin-1, in Normal and Cystic Tissue

    Article • American Journal Of Pathology, June 1999, Elsevier

    Professor Albert Ong

  181. Cyst formation in ADPKD: new insights from natural and targeted mutants

    Article • Nephrology Dialysis Transplantation, March 1999, Oxford University Press (OUP)

    Professor Albert Ong

  182. Regional Variations in Endothelin-1 and its Receptor Subtypes in Human Coronary Vasculature: Pathophysiological Implications in Coronary Disease

    Article • Endothelium, January 1998, Taylor & Francis

    Professor Albert Ong

  183. Molecular basis of renal cyst formation—one hit or two?

    Article • The Lancet, April 1997, Elsevier

    Professor Albert Ong

  184. A stable, nonsense mutation associated with a case of infantile onset polycystic kidney disease 1 (PKD1)

    Article • Human Molecular Genetics, April 1996, Oxford University Press (OUP)

    Professor Albert Ong

  185. Polycystin, the polycystic kidney disease 1 protein, is expressed by epithelial cells in fetal, adult, and polycystic kidney.

    Article • Proceedings of the National Academy of Sciences, February 1996, Proceedings of the National Academy of Sciences

    Professor Albert Ong

  186. Candidate 56 and 58 kDa protein(s) responsible for mediating the renal defects in oncogenic hypophosphatemic osteomalacia

    Article • Bone, February 1996, Elsevier

    Professor Albert Ong

  187. Tubulointerstitial actions of endothelins in the kidney: roles in health and disease

    Article • Nephrology Dialysis Transplantation, February 1996, Oxford University Press (OUP)

    Professor Albert Ong

  188. Tubulointerstitial actions of endothelins in the kidney: roles in health and disease

    Article • Nephrology Dialysis Transplantation, February 1996, Oxford University Press (OUP)

    Professor Albert Ong

  189. Oncogenous hypophosphataemic osteomalacia: effects on phosphate transport and vitamin D metabolism in cultured human kidney cells

    Article • Bone, June 1995, Elsevier

    Professor Albert Ong

  190. Human high density lipoproteins stimulate endothelin-1 release by cultured human renal proximal tubular cells

    Article • Kidney International, November 1994, Elsevier

    Professor Albert Ong

  191. Tubular lipidosis: Epiphenomenon or pathogenetic lesion in human renal disease?

    Article • Kidney International, March 1994, Elsevier

    Professor Albert Ong

  192. Loss of glomerular function and tubulointerstitial fibrosis:Cause or effect?

    Article • Kidney International, February 1994, Elsevier

    Professor Albert Ong

  193. Tubular-Derived Growth Factors and Cytokines in the Pathogenesis of Tubulointerstitial Fibrosis: Implications for Human Renal Disease Progression

    Article • American Journal of Kidney Diseases, February 1994, Elsevier

    Professor Albert Ong

  194. Tubular-derived cytokines and human renal disease progression

    Article • Nephrology Dialysis Transplantation, January 1994, Oxford University Press (OUP)

    Professor Albert Ong

  195. Mechanisms of tubulo‐interstitiaI injury in progressive renal diseases

    Article • European Journal of Clinical Investigation, May 1993, Wiley

    Professor Albert Ong

  196. Effect of cyclosporin A on endothelin synthesis by cultured human renal cortical epithelial cells

    Article • Nephrology Dialysis Transplantation, January 1993, Oxford University Press (OUP)

    Professor Albert Ong

  197. Sinus arrest and asystole due to severe lithium intoxication

    Article • International Journal of Cardiology, March 1991, Elsevier

    Professor Albert Ong

  198. The pathogenesis of the ovarian hyperstimulation syndrome (OHS): a possible role for ovarian renin

    Article • Clinical Endocrinology, January 1991, Wiley

    Professor Albert Ong

  199. Atrial natriuretic peptide release responds to atrial stretch and not to atrial pressure: observations during pericardiocentesis in a young woman

    Article • European Heart Journal, April 1990, Oxford University Press (OUP)

    Professor Albert Ong

  200. The Use of Lithium Clearance in Bartter's Syndrome

    Article • Nephrology Dialysis Transplantation, January 1990, Oxford University Press (OUP)

    Professor Albert Ong

  201. Intermittent absorption of warfarin caused by an unrecognized pharyngeal pouch

    Article • Postgraduate Medical Journal, September 1989, Oxford University Press (OUP)

    Professor Albert Ong

  202. Effects of noradrenaline infusion on platelet catecholamine levels and platelet aggregation

    Article • Journal of Hypertension, January 1989, Wolters Kluwer Health

    Professor Albert Ong

  203. Hypersensitivity vasculitis complicating intravenous streptokinase therapy in acute myocardial infarction

    Article • International Journal of Cardiology, October 1988, Elsevier

    Professor Albert Ong