All Stories

  1. TARDBP as a Gatekeeper of HIV-1 Assembly and Infection: Targeting the Viral Capsid Precursor Pr55Gag and Limiting Viral Core Entry

    Article • October 2025, MDPI AG

    Dr Agustin Valenzuela-Fernandez

  2. The ZIKV NS5 Protein Aberrantly Alters the Tubulin Cytoskeleton, Induces the Accumulation of Autophagic p62 and Affects IFN Production: HDAC6 Has Emerged as an Anti-NS5/ZIKV Factor

    Article • Cells, March 2024, MDPI AG

    Dr Agustin Valenzuela-Fernandez

  3. The ZIKV NS5 Protein Aberrantly Alters the Tubulin Cytoskeleton, Induces the Accumulation of Autophagic p62 and Affects IFN Production: HDAC6 Has Emerged as an Anti-NS5/ZIKV Factor

    Article • February 2024, MDPI AG

    Dr Agustin Valenzuela-Fernandez

  4. HIV Infection: Shaping the Complex, Dynamic, and Interconnected Network of the Cytoskeleton

    Article • International Journal of Molecular Sciences, August 2023, MDPI AG

    Dr Agustin Valenzuela-Fernandez

  5. Reinfection rate and disease severity of the BA.5 Omicron SARS-CoV-2 lineage compared to previously circulating variants of concern in the Canary Islands (Spain)

    Article • Emerging Microbes & Infections, May 2023, Taylor & Francis

    Dr Agustin Valenzuela-Fernandez

  6. TDP-43 Controls HIV-1 Viral Production and Virus Infectiveness

    Article • International Journal of Molecular Sciences, April 2023, MDPI AG

    Dr Agustin Valenzuela-Fernandez

  7. Bioinformatic approaches to draft the viral genome sequence of Canary Islands cases related to the multicountry mpox virus 2022-outbreak

    Article • Computational and Structural Biotechnology Journal, January 2023, Elsevier

    Dr Agustin Valenzuela-Fernandez

  8. Nanomaterials to combat SARS-CoV-2: Strategies to prevent, diagnose and treat COVID-19

    Article • Frontiers in Bioengineering and Biotechnology, November 2022, Frontiers

    Dr Agustin Valenzuela-Fernandez

  9. Bioinformatic approaches to draft the viral genome sequence of Canary Islands cases related to the multi-country Monkeypox virus 2022-outbreak

    Article • November 2022, Cold Spring Harbor Laboratory Press

    Dr Agustin Valenzuela-Fernandez

  10. Tracing the trajectories of SARS-CoV-2 variants of concern between December 2020 and September 2021 in the Canary Islands (Spain)

    Article • Frontiers in Cellular and Infection Microbiology, September 2022, Frontiers

    Dr Agustin Valenzuela-Fernandez

  11. Contribution of the HIV-1 Envelope Glycoprotein to AIDS Pathogenesis and Clinical Progression

    Article • Biomedicines, September 2022, MDPI AG

    Dr Agustin Valenzuela-Fernandez

  12. Association of the Delta SARS-CoV-2 variant with 28-day hospital mortality between December 2020 and September 2021

    Article • Journal of Infection, July 2022, Elsevier

    Dr Agustin Valenzuela-Fernandez

  13. Transactive Response DNA-Binding Protein (TARDBP/TDP-43) Regulates Cell Permissivity to HIV-1 Infection by Acting on HDAC6

    Article • International Journal of Molecular Sciences, May 2022, MDPI AG

    Dr Agustin Valenzuela-Fernandez

  14. The Characteristics of the HIV-1 Env Glycoprotein Are Linked With Viral Pathogenesis

    Article • Frontiers in Microbiology, March 2022, Frontiers

    Dr Agustin Valenzuela-Fernandez

  15. Tracing the trajectories of SARS-CoV-2 variants of concern between December 2020 and September 2021 in the Canary Islands (Spain)

    Article • February 2022, Cold Spring Harbor Laboratory Press

    Dr Agustin Valenzuela-Fernandez

  16. A Conserved uORF Regulates APOBEC3G Translation and Is Targeted by HIV-1 Vif Protein to Repress the Antiviral Factor

    Article • Biomedicines, December 2021, MDPI AG

    Dr Agustin Valenzuela-Fernandez

  17. Transactive response DNA-binding Protein (TDP-43) regulates early HIV-1 entry and infection

    Article • December 2021, Cold Spring Harbor Laboratory Press

    Dr Agustin Valenzuela-Fernandez

  18. Longitudinal study of a SARS-CoV-2 infection in an immunocompromised patient with X-linked agammaglobulinemia

    Article • Journal of Infection, November 2021, Elsevier

    Dr Agustin Valenzuela-Fernandez

  19. Longitudinal study of a SARS-CoV-2 infection in an immunocompromised patient with X-linked agammaglobulinemia

    Article • July 2021, Springer Science + Business Media

    Dr Agustin Valenzuela-Fernandez

  20. The characteristics of the HIV-1 Env glycoprotein contribute to viral pathogenesis

    Article • July 2021, Cold Spring Harbor Laboratory Press

    Dr Agustin Valenzuela-Fernandez

  21. Monitoring the rise of the SARS-CoV-2 lineage B.1.1.7 in Tenerife (Spain) since mid-December 2020

    Article • Journal of Infection, June 2021, Elsevier

    Dr Agustin Valenzuela-Fernandez

  22. The Interplay of HIV and Autophagy in Early Infection

    Article • Frontiers in Microbiology, April 2021, Frontiers

    Dr Agustin Valenzuela-Fernandez

  23. Zika Virus Pathogenesis: A Battle for Immune Evasion

    Article • Vaccines, March 2021, MDPI AG

    Dr Agustin Valenzuela-Fernandez

  24. Monitoring the rise of the SARS-CoV-2 lineage B.1.1.7 in Tenerife (Spain) since mid-December 2020

    Article • March 2021, Cold Spring Harbor Laboratory Press

    Dr Agustin Valenzuela-Fernandez

  25. Increasing SARS-CoV-2 RT-qPCR testing capacity by sample pooling

    Article • International Journal of Infectious Diseases, February 2021, Elsevier

    Dr Agustin Valenzuela-Fernandez

  26. A conserved uORF regulates APOBEC3G translation and is targeted by HIV-1 Vif protein to repress the antiviral factor

    Article • January 2021, Cold Spring Harbor Laboratory Press

    Dr Agustin Valenzuela-Fernandez

  27. Increasing SARS-CoV-2 RT-qPCR testing capacity by sample pooling

    Article • October 2020, Cold Spring Harbor Laboratory Press

    Dr Agustin Valenzuela-Fernandez

  28. Sensitivity of different RT-qPCR solutions for SARS-CoV-2 detection

    Article • International Journal of Infectious Diseases, October 2020, Elsevier

    Dr Agustin Valenzuela-Fernandez

  29. Fast SARS-CoV-2 detection by RT-qPCR in preheated nasopharyngeal swab samples

    Article • International Journal of Infectious Diseases, August 2020, Elsevier

    Dr Agustin Valenzuela-Fernandez

  30. Sensitivity of different RT-qPCR solutions for SARS-CoV-2 detection

    Article • June 2020, Cold Spring Harbor Laboratory Press

    Dr Agustin Valenzuela-Fernandez

  31. Fast SARS-CoV-2 detection by RT-qPCR in preheated nasopharyngeal swab samples

    Article • April 2020, Cold Spring Harbor Laboratory Press

    Dr Agustin Valenzuela-Fernandez

  32. HIV-1 Nef Targets HDAC6 to Assure Viral Production and Virus Infection

    Article • Frontiers in Microbiology, October 2019, Frontiers

    Dr Agustin Valenzuela-Fernandez

  33. Lower expression of plasma-derived exosome miR-21 levels in HIV-1 elite controllers with decreasing CD4 T cell count

    Article • Journal of Microbiology Immunology and Infection, August 2019, Elsevier

    Dr Agustin Valenzuela-Fernandez

  34. HIV-1 envelope glycoproteins isolated from Viremic Non-Progressor individuals are fully functional and cytopathic

    Article • Scientific Reports, April 2019, Springer Science + Business Media

    Dr Agustin Valenzuela-Fernandez

  35. Immunometabolism is a key factor for the persistent spontaneous elite control of HIV-1 infection

    Article • EBioMedicine, April 2019, Elsevier

    Dr Agustin Valenzuela-Fernandez

  36. Desarrollo de una Animación 3D sobre la Microscopia de Onda Evanescente y su aplicación en Virología: una herramienta para el estudio y comprensión de los mecanismos de infección por microorganismos en célula viva

    Article • January 2019, University of La Laguna

    Dr Agustin Valenzuela-Fernandez

  37. High Plasma Levels of sTNF-R1 and CCL11 Are Related to CD4+ T-Cells Fall in Human Immunodeficiency Virus Elite Controllers With a Sustained Virologic Control

    Article • Frontiers in Immunology, June 2018, Frontiers

    Dr Agustin Valenzuela-Fernandez

  38. Erratum: Corrigendum: HIV-1 Env associates with HLA-C free-chains at the cell membrane modulating viral infectivity

    Article • Scientific Reports, May 2018, Springer Science + Business Media

    Donato Zipeto, Dr Agustin Valenzuela-Fernandez

  39. Viral defective HIV-1-Env could be responsible for natural control of HIV-1 infection.

    Article • mBio, April 2018, ASM Journals

    Dr Agustin Valenzuela-Fernandez, Cecilio Lopez-Galindez

  40. HLA-B*57 and IFNL4-Related Polymorphisms Are Associated With Protection Against HIV-1 Disease Progression in Controllers

    Article • Clinical Infectious Diseases, February 2017, Oxford University Press (OUP)

    Dr Agustin Valenzuela-Fernandez

  41. HIV-1 Env associates with HLA-C free-chains at the cell membrane modulating viral infectivity

    Article • Scientific Reports, January 2017, Springer Science + Business Media

    Donato Zipeto, Dr Agustin Valenzuela-Fernandez

  42. MicroRNA Profile in CD8+ T-Lymphocytes from HIV-Infected Individuals: Relationship with Antiviral Immune Response and Disease Progression

    Article • PLOS One, May 2016, PLOS

    Dr. Vicente Soriano, Dr Agustin Valenzuela-Fernandez

  43. Membrane structures and viral infection

    Article • Reviews in Medical Virology, January 2016, Wiley

    Dr Agustin Valenzuela-Fernandez

  44. The HDAC6/APOBEC3G complex regulates HIV-1 infectiveness by inducing Vif autophagic degradation

    Article • Retrovirology, June 2015, Springer Science + Business Media

    Dr Agustin Valenzuela-Fernandez

  45. Quantitative Analysis of the Processes and Signaling Events Involved in Early HIV-1 Infection of T Cells

    Article • PLOS One, August 2014, PLOS

    Dr Agustin Valenzuela-Fernandez

  46. Gelsolin activity controls efficient early HIV-1 infection

    Article • Retrovirology, January 2013, Springer Science + Business Media

    Donato Zipeto, Dr Agustin Valenzuela-Fernandez

  47. Viral infection

    Article • Communicative & Integrative Biology, July 2011, Taylor & Francis

    Dr Agustin Valenzuela-Fernandez

  48. HIV-1 requires Arf6-mediated membrane dynamics to efficiently enter and infect T lymphocytes

    Article • Molecular Biology of the Cell, April 2011, American Society for Cell Biology (ASCB)

    Dr Agustin Valenzuela-Fernandez

  49. The Tight Junction-Associated Protein Occludin Is Required for a Postbinding Step in Hepatitis C Virus Entry and Infection

    Article • Journal of Virology, June 2009, ASM Journals

    Dr Agustin Valenzuela-Fernandez

  50. The Lupane-type Triterpene 30-Oxo-calenduladiol Is a CCR5 Antagonist with Anti-HIV-1 and Anti-chemotactic Activities

    Article • Journal of Biological Chemistry, June 2009, Elsevier

    Dr Agustin Valenzuela-Fernandez

  51. Moesin Regulates the Trafficking of Nascent Clathrin-coated Vesicles

    Article • Journal of Biological Chemistry, January 2009, Elsevier

    Dr Agustin Valenzuela-Fernandez

  52. Moesin is required for HIV-1-induced CD4-CXCR4 interaction, F-actin redistribution, membrane fusion and viral infection in lymphocytes

    Article • Journal of Cell Science, January 2009, The Company of Biologists

    Dr Agustin Valenzuela-Fernandez

  53. PI4P5-Kinase Iα Is Required for Efficient HIV-1 Entry and Infection of T Cells

    Article • The Journal of Immunology, November 2008, Oxford University Press (OUP)

    Dr Agustin Valenzuela-Fernandez

  54. HDAC6: a key regulator of cytoskeleton, cell migration and cell–cell interactions

    Article • Trends in Cell Biology, June 2008, Elsevier

    Dr Agustin Valenzuela-Fernandez

  55. Expression and Regulation of the Metalloproteinase ADAM-8 during Human Neutrophil Pathophysiological Activation and Its Catalytic Activity on L-Selectin Shedding

    Article • The Journal of Immunology, June 2007, Oxford University Press (OUP)

    Dr Agustin Valenzuela-Fernandez

  56. Chemical modulation of VLA integrin affinity in human breast cancer cells

    Article • Experimental Cell Research, April 2007, Elsevier

    Dr Agustin Valenzuela-Fernandez

  57. Myosin IIA is involved in the endocytosis of CXCR4 induced by SDF-1α

    Article • Journal of Cell Science, March 2007, The Company of Biologists

    Dr Agustin Valenzuela-Fernandez

  58. The role of actomyosin and the microtubular network in both the immunological synapse and T cell activation

    Article • Frontiers in Bioscience, January 2007, IMR Press

    Dr Agustin Valenzuela-Fernandez

  59. Tetraspanins CD9 and CD81 Modulate HIV-1-Induced Membrane Fusion

    Article • The Journal of Immunology, October 2006, Oxford University Press (OUP)

    Dr Agustin Valenzuela-Fernandez

  60. Lymphocyte Chemotaxis Is Regulated by Histone Deacetylase 6, Independently of Its Deacetylase Activity

    Article • Molecular Biology of the Cell, May 2006, American Society for Cell Biology (ASCB)

    Dr Miguel Vicente-Manzanares, Dr Agustin Valenzuela-Fernandez

  61. Histone Deacetylase 6 Regulates Human Immunodeficiency Virus Type 1 Infection

    Article • Molecular Biology of the Cell, November 2005, American Society for Cell Biology (ASCB)

    Dr Agustin Valenzuela-Fernandez

  62. Low levels of co-receptor CCR5 are sufficient to permit HIV envelope-mediated fusion with resting CD4 T cells

    Article • AIDS, November 2002, Wolters Kluwer Health

    Dr Agustin Valenzuela-Fernandez

  63. Leukocyte Elastase Negatively Regulates Stromal Cell-derived Factor-1 (SDF-1)/CXCR4 Binding and Functions by Amino-terminal Processing of SDF-1 and CXCR4

    Article • Journal of Biological Chemistry, May 2002, Elsevier

    Dr Agustin Valenzuela-Fernandez

  64. Palmitoylation-dependent Control of Degradation, Life Span, and Membrane Expression of the CCR5 Receptor

    Article • Journal of Biological Chemistry, August 2001, Elsevier

    Dr Agustin Valenzuela-Fernandez

  65. Optimal Inhibition of X4 HIV Isolates by the CXC Chemokine Stromal Cell-derived Factor 1α Requires Interaction with Cell Surface Heparan Sulfate Proteoglycans

    Article • Journal of Biological Chemistry, July 2001, Elsevier

    Dr Agustin Valenzuela-Fernandez

  66. The HIV‐1 gp120 inhibits the binding of adenosine deaminase to CD26 by a mechanism modulated by CD4 and CXCR4 expression

    Article • FEBS Letters, July 2000, Wiley

    Dr Agustin Valenzuela-Fernandez

  67. Stromal Cell-derived Factor-1α Associates with Heparan Sulfates through the First β-Strand of the Chemokine

    Article • Journal of Biological Chemistry, August 1999, Elsevier

    Dr Agustin Valenzuela-Fernandez

  68. Enzymatic and extraenzymatic role of ecto‐adenosine deaminase in lymphocytes

    Article • Immunological Reviews, February 1998, Wiley

    Dr Agustin Valenzuela-Fernandez