All Stories

  1. The Immune-Chemokine Axis in Alzheimer’s Disease: Roles of Adaptive Immune System in Neuroinflammation and Disease Progression

    Article • Biomolecules, June 2026, MDPI AG

    Dr Adolfo Toledano

  2. Plasma Biomarkers Panel for Early Differential Diagnosis of Alzheimer’s Disease and Frontotemporal Dementia: Role of Soluble Fractalkine in Both Diseases and Against Inflammation in Cortical Neurons In Vitro

    Article • January 2026, MDPI AG

    Dr Adolfo Toledano

  3. Relationship between Alzheimer's Disease and Type 2 Diabetes: Critical Review On Cellular and Molecular Common Pathogenic Mechanisms

    Article • Current Alzheimer Research, February 2025, Bentham Science Publishers

    Dr Adolfo Toledano

  4. Neurofeedback Technology Reduces Cortisol Levels in Bruxismitle Patients: Assessment of Cerebral Activity and Anxiolytic Effects of Origanum majorana Essential Oil

    Article • Biomimetics, November 2024, MDPI AG

    Dr Adolfo Toledano

  5. Alzheimer’s Disease, Obesity, and Type 2 Diabetes: Focus on Common Neuroglial Dysfunctions (Critical Review and New Data on Human Brain and Models)

    Article • Brain Sciences, October 2024, MDPI AG

    Dr Adolfo Toledano

  6. Alzheimer’s Disease and Type 2 Diabetes Relationships. I. Cellular and Molecular Common Pathological Mechanisms

    Article • May 2024, MDPI AG

    Dr Adolfo Toledano

  7. The relationships between neuroglial alterations and neuronal changes in Alzheimer’s disease, and the related controversies I: Gliopathogenesis and glioprotection

    Article • Journal of Central Nervous System Disease, April 2022, SAGE Publications

    Dr Adolfo Toledano

  8. The relationships between neuroglial and neuronal changes in Alzheimer’s disease, and the related controversies II: gliotherapies and multimodal therapy

    Article • Journal of Central Nervous System Disease, April 2022, SAGE Publications

    Dr Adolfo Toledano

  9. Reflections on Cerebellar Neuropathology in Classical Scrapie

    Article • Biomolecules, April 2021, MDPI AG

    Dr Adolfo Toledano

  10. Glial Alterations in Aging and Alzheimer’s Disease: A Novel Basis to Understand, Prevent and Treat the Degenerative Process

    Article • May 2020, Open BioMedical Publishing Corporation

    Dr Adolfo Toledano

  11. Hippocampal CCR5/RANTES Elevations in a Rodent Model of Post-Traumatic Stress Disorder: Maraviroc (a CCR5 Antagonist) Increases Corticosterone Levels and Enhances Fear Memory Consolidation

    Article • Biomolecules, February 2020, MDPI AG

    Dr Adolfo Toledano

  12. Elevated Systemic L-Kynurenine/L-Tryptophan Ratio and Increased IL-1 Beta and Chemokine (CX3CL1, MCP-1) Proinflammatory Mediators in Patients with Long-Term Titanium Dental Implants

    Article • Journal of Clinical Medicine, September 2019, MDPI AG

    Dr Adolfo Toledano

  13. The Long-Term Algae Extract (Chlorella and Fucus sp) and Aminosulphurate Supplementation Modulate SOD-1 Activity and Decrease Heavy Metals (Hg++, Sn) Levels in Patients with Long-Term Dental Titanium Implants and Amalgam Fillings Restorations

    Article • Antioxidants, April 2019, MDPI AG

    Dr Adolfo Toledano

  14. Defective Insulin Signalling, Mediated by Inflammation, Connects Obesity to Alzheimer Disease; Relevant Pharmacological Therapies and Preventive Dietary Interventions

    Article • Current Alzheimer Research, July 2017, Bentham Science Publishers

    Dr Adolfo Toledano

  15. Morphological Changes of Glia in Prion and a Prion-Like Disorder

    Article • Alzheimer’s & Neurodegenerative Diseases, May 2016, Herald Scholarly Open Access

    Dr Adolfo Toledano

  16. Brain local and regional neuroglial alterations in Alzheimers Disease: cell types, responses and implications.

    Article • Current Alzheimer Research, March 2016, Bentham Science Publishers

    Dr Adolfo Toledano

  17. Blood-Based Biomarkers of Alzheimers Disease: Diagnostic Algorithms and New Technologies

    Article • Current Alzheimer Research, March 2016, Bentham Science Publishers

    Dr Adolfo Toledano

  18. Editorial (Thematic Issue: Neuroglia in Alzheimer's Disease: From Cohort to Contestant in the Disease Progression and its Therapy)

    Article • Current Alzheimer Research, March 2016, Bentham Science Publishers

    Dr Adolfo Toledano

  19. Vibrational spectroscopic analysis of peripheral blood plasma of patients with Alzheimer’s disease

    Article • Fresenius Journal of Analytical Chemistry, August 2015, Springer Science + Business Media

    Dr Adolfo Toledano

  20. Ultrastructural changes in the progress of natural Scrapie regardless fixation protocol

    Article • Histochemistry and Cell Biology, February 2015, Springer Science + Business Media

    Dr Adolfo Toledano

  21. Variability in the Effects of Nicotine on Different Regions of the Brain: Changes in the Concentration of Superoxide Dismutase Isoforms

    Article • Central Nervous System Agents in Medicinal Chemistry, November 2014, Bentham Science Publishers

    Dr Adolfo Toledano

  22. Astroglial cell subtypes in the cerebella of normal adults, elderly adults, and patients with Alzheimer's disease: A histological and immunohistochemical comparison

    Article • Glia, September 2014, Wiley

    Dr Adolfo Toledano

  23. Morphological approach to assess the involvement of astrocytes in prion propagation

    Article • Cell and Tissue Research, June 2014, Springer Science + Business Media

    Dr Adolfo Toledano

  24. Does Alzheimer disease exist in all primates? Alzheimer pathology in non-human primates and its pathophysiological implications (II)

    Article • Neurología (English Edition), January 2014, Elsevier

    Dr Adolfo Toledano

  25. ¿Existe la enfermedad de Alzheimer en todos los primates? Patología Alzheimer en primates no humanos y sus implicaciones fisiopatológicas (II)

    Article • Neurología, January 2014, Elsevier

    Dr Adolfo Toledano

  26. Discrimination Analysis of Blood Plasma Associated with Alzheimer's Disease Using Vibrational Spectroscopy

    Article • Journal of Alzheimer’s Disease, March 2013, SAGE Publications

    Dr Adolfo Toledano

  27. ¿Existe la enfermedad de Alzheimer en todos los primates? Afección de Alzheimer en primates no humanos y sus implicaciones fisiopatológicas (I)

    Article • Neurología, July 2012, Elsevier

    Dr Adolfo Toledano

  28. Infrared spectroscopic analysis of mononuclear leukocytes in peripheral blood from Alzheimer’s disease patients

    Article • Fresenius Journal of Analytical Chemistry, January 2012, Springer Science + Business Media

    Dr Adolfo Toledano

  29. Changes Induced by Natural Scrapie in the Calretinin-Immunopositive Cells and Fibres of the Sheep Cerebellar Cortex

    Article • The Cerebellum, November 2011, Springer Science + Business Media

    Dr Adolfo Toledano

  30. Lesion-Induced Vertebrate Models of Alzheimer Dementia

    Article • October 2010, Springer Science + Business Media

    Dr Adolfo Toledano

  31. Diversity and Variability of the Effects of Nicotine on Different Cortical Regions of the Brain. Therapeutic and Toxicological Implications

    Article • Central Nervous System Agents in Medicinal Chemistry, September 2010, Bentham Science Publishers

    Dr Adolfo Toledano

  32. Calretinin-immunopositive Cells and Fibers in the Cerebellar Cortex of Normal Sheep

    Article • The Cerebellum, July 2008, Springer Science + Business Media

    Dr Adolfo Toledano

  33. Immunohistochemical increase in cyclooxygenase-2 without apoptosis in different brain areas of subchronic nicotine- and d-amphetamine-treated rats

    Article • Journal of Neural Transmission, March 2008, Springer Science + Business Media

    Dr Adolfo Toledano

  34. FTIR microspectroscopic analysis of the effects of certain drugs on oxidative stress and brain protein structure

    Article • Biopolymers, January 2008, Wiley

    Dr Arantxa Rodriguez-Casado, Dr Adolfo Toledano

  35. Amphetamine effects on brain protein structure and oxidative stress as revealed by FTIR microspectroscopy

    Article • Biopolymers, January 2007, Wiley

    Dr Arantxa Rodriguez-Casado, Dr Adolfo Toledano

  36. Lesions and Dysfunctions of the Nucleus Basalis as Alzheimers Disease Models: General and Critical Overview and Analysis of the Long-Term Changes in Several Excitotoxic Models

    Article • Current Alzheimer Research, August 2004, Bentham Science Publishers

    Dr Adolfo Toledano

  37. Nueva célula ‘en cepillo’ (brush cell) o célula monopolar del cerebelo. Características y posible función

    Article • Revista de Neurología, January 2004, IMR Press

    Dr Adolfo Toledano

  38. Chronic nicotine administration increases NGF-like immunoreactivity in frontoparietal cerebral cortex

    Article • Journal of Neuroscience Research, July 2003, Wiley

    Dr Ignacio Alvarez Gomez de Segura, Dr Adolfo Toledano

  39. Inervación de la glándula lagrimal en pacientes con síndrome de Sjögren primario: Estudio inmunohistopatológico

    Article • Archivos de la Sociedad Española de Oftalmología, November 2002, Elsevier

    Dr Adolfo Toledano

  40. Histochemical study of acute and chronic intraperitoneal nicotine effects on several glycolytic and Krebs cycle dehydrogenase activities in the frontoparietal cortex and subcortical nuclei of the rat brain

    Article • Journal of Neuroscience Research, June 2001, Wiley

    Dr Adolfo Toledano

  41. Long-term evolution of local, proximal and remote astrocyte responses after diverse nucleus basalis lesioning (an experimental Alzheimer model): GFAP immunocytochemical study

    Article • Brain Research, May 2000, Elsevier

    Dr Adolfo Toledano

  42. Localization of glyoxylate dehydrogenase and glyoxylate-complex molecules in the rat prefrontal cortex: enzymohistochemical and immunocytochemical study

    Article • Journal of Neuroscience Research, February 2000, Wiley

    Dr Ignacio Alvarez Gomez de Segura, Dr Adolfo Toledano

  43. Repeated intracerebroventricular administration of β-amyloid25–35 to rats decreases muscarinic receptors in cerebral cortex

    Article • Neuroscience Letters, January 2000, Elsevier

    Dr Adolfo Toledano

  44. Amyloid precursor proteins in the cerebellar cortex of Alzheimer's disease patients devoid of cerebellar β-amyloid deposits: immunocytochemical study of five cases

    Article • Journal of Neural Transmission, February 1999, Springer Science + Business Media

    Dr Adolfo Toledano

  45. Synaptic immunolocalization of glyoxylate-complex molecules in the striate areas of the rat cerebral cortex: Light and electron microscopic studies

    Article • Journal of Neuroscience Research, January 1998, Wiley

    Dr Ignacio Alvarez Gomez de Segura, Dr Adolfo Toledano

  46. Synaptic immunolocalization of glyoxylate‐complex molecules in the striate areas of the rat cerebral cortex: Light and electron microscopic studies

    Article • Journal of Neuroscience Research, January 1998, Wiley

    Dr Adolfo Toledano

  47. Ultrastructural Study of the Conjunctiva in Patients with Keratoconjunctivitis Sicca not Associated with Systemic Disorders

    Article • European Journal of Ophthalmology, January 1998, SAGE Publications

    Dr Adolfo Toledano

  48. Pyritinol facilitates the recovery of cortical cholinergic deficits caused by nucleus basalis lesions

    Article • Journal of Neural Transmission - Parkinsons Disease and Dementia Section, October 1994, Springer Science + Business Media

    Dr Adolfo Toledano

  49. Mitochondria, brain aging and neurodegenerative disorders

    Article • Aging Clinical and Experimental Research, December 1993, Springer Science + Business Media

    Dr Adolfo Toledano

  50. Inter- and intracellular communication in CNS

    Article • European Neuropsychopharmacology, September 1992, Elsevier

    Dr Adolfo Toledano

  51. Autoradiographic localization of receptors for glucagon-like peptide-1(7–36) amide in rat brain

    Article • Neuropeptides, March 1992, Elsevier

    Dr Adolfo Toledano

  52. Morphometric and neurosecretory changes in supraoptic neurons after D-amphetamine treatment

    Article • Journal of Neural Transmission, February 1992, Springer Science + Business Media

    Dr Adolfo Toledano

  53. Hypotheses Concerning the Aetiology of Alzheimer's Disease

    Article • Pharmacopsychiatry, January 1988, Thieme Publishing Group

    Dr Adolfo Toledano

  54. Mitochondrial accumulation of Sr2+ supported by pyruvate in the cerebellar cortex of the rat. Cellular variations during aging.

    Article • ACTA HISTOCHEMICA ET CYTOCHEMICA, January 1988, Japan Society of Histochemistry & Cytochemistry

    Dr Adolfo Toledano

  55. Study on, distribution of polyanionic substances and glycoproteins in albino rats hippocampus during post-natal development

    Article • Acta Histochemica, January 1981, Elsevier

    Dr Adolfo Toledano

  56. Distribution of peripherally stained neurons by the Colloidal Iron histochemical method in albino rat cerebral cortex. A quantitative study

    Article • Neuroscience Letters, April 1980, Elsevier

    Dr Adolfo Toledano

  57. Histochemical characteristics of diphosphate nucleoside consumption in, cat and rat nervous system

    Article • Acta Histochemica, January 1979, Elsevier

    Dr Adolfo Toledano

  58. Diaminobenzidine oxidation in cerebellar histological sections

    Article • Acta Histochemica, January 1978, Elsevier

    Dr Adolfo Toledano

  59. Glycoproteins and polyanions in the synapses of rat and mouse central nervous system

    Article • Acta Histochemica, January 1978, Elsevier

    Dr Adolfo Toledano

  60. Localization of aspartate aminotransferase and glutamic dehydrogenase in the Edinger-Westphal and oculomotor nuclei of Lacerta lepida

    Article • Neuroscience Letters, October 1977, Elsevier

    Dr Adolfo Toledano

  61. Mucopolysaccharides in the dog spinal cord and dorsal root ganglia

    Article • Cells Tissues Organs, January 1977, Karger Publishers

    Dr Adolfo Toledano

  62. A histochemical investigation on mucopolysaccharides in the dog sympathetic ganglia

    Article • Acta Histochemica, January 1976, Elsevier

    Dr Adolfo Toledano

  63. Histochemical study of mucopolysaccharides in the subthalamic region of rats

    Article • Acta Histochemica, January 1976, Elsevier

    Dr Adolfo Toledano