All Stories

  1. Myeloid Heterogeneity Mediates Acute Exacerbations of Pulmonary Fibrosis

    Article • The Journal of Immunology, October 2023, The American Association of Immunologists

    Dr A Brent Carter

  2. Impaired PPARɣ activation by cadmium exacerbates infection-induced lung injury

    Article • JCI Insight, March 2023, American Society for Clinical Investigation

    Dr A Brent Carter

  3. Mitochondrial fission and bioenergetics mediate human lung fibroblast durotaxis

    Article • JCI Insight, November 2022, American Society for Clinical Investigation

    Dr A Brent Carter

  4. CRTH2 in Pulmonary Fibrosis: Friend or Foe?

    Article • American Journal of Respiratory Cell and Molecular Biology, June 2022, American Thoracic Society

    Dr A Brent Carter

  5. Does UCP2 Couple Hyperoxia to Lung Injury?

    Article • American Journal of Respiratory Cell and Molecular Biology, December 2021, American Thoracic Society

    Dr A Brent Carter

  6. Targeting Cpt1a-Bcl-2 interaction modulates apoptosis resistance and fibrotic remodeling

    Article • Cell Death and Differentiation, August 2021, Springer Science + Business Media

    Dr A Brent Carter

  7. NOX4 regulates macrophage apoptosis resistance to induce fibrotic progression

    Article • Journal of Biological Chemistry, July 2021, Elsevier

    Dr A Brent Carter

  8. Technical advance: The use of tree shrews as a model of pulmonary fibrosis

    Article • PLoS ONE, November 2020, PLOS

    Dr A Brent Carter

  9. Cadmium-mediated lung injury is exacerbated by the persistence of classically activated macrophages

    Article • Journal of Biological Chemistry, September 2020, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr A Brent Carter

  10. C(C)Learing the Role of Chemokines in Pulmonary Fibrosis

    Article • American Journal of Respiratory Cell and Molecular Biology, May 2020, American Thoracic Society

    Dr A Brent Carter

  11. Mitochondrial quality control in pulmonary fibrosis

    Article • Redox Biology, January 2020, Elsevier

    Dr A Brent Carter

  12. We found that supplying more substrate for Rac1 activation increased fibrosis with injury.

    Article • Journal of Clinical Investigation, October 2019, American Society for Clinical Investigation

    Dr A Brent Carter

  13. Mitochondrial calcium uniporter regulates PGC-1α expression to mediate metabolic reprogramming in pulmonary fibrosis

    Article • Redox Biology, September 2019, Elsevier

    Dr A Brent Carter

  14. NOX4 modulates macrophage phenotype and mitochondrial biogenesis in asbestosis

    Article • JCI Insight, August 2019, American Society for Clinical Investigation

    Dr A Brent Carter

  15. Reply to Eapen et al.: Dysfunctional Immunity and Microbial Adhesion Molecules in Smoking-induced Pneumonia

    Article • American Journal of Respiratory and Critical Care Medicine, January 2019, American Thoracic Society

    Dr A Brent Carter

  16. Discover why patients that smoke have more severe lung infections.

    Article • American Journal of Respiratory and Critical Care Medicine, November 2018, American Thoracic Society

    Dr A Brent Carter

  17. Serpine 1 induces alveolar type II cell senescence through activating p53-p21-Rb pathway in fibrotic lung disease

    Article • Aging Cell, July 2017, Wiley

    Dr A Brent Carter

  18. Macrophages utilize the mitochondrial calcium uniporter for profibrotic polarization

    Article • The FASEB Journal, March 2017, Federation of American Societies For Experimental Biology (FASEB)

    Dr A Brent Carter, Linlin Gu

  19. NADPH Oxidase 4 (Nox4) Suppresses Mitochondrial Biogenesis and Bioenergetics in Lung Fibroblasts via a Nuclear Factor Erythroid-derived 2-like 2 (Nrf2)-dependent Pathway

    Article • Journal of Biological Chemistry, January 2017, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr A Brent Carter

  20. Cu,Zn–Superoxide Dismutase–Mediated Redox Regulation of Jumonji Domain Containing 3 Modulates Macrophage Polarization and Pulmonary Fibrosis

    Article • American Journal of Respiratory Cell and Molecular Biology, July 2016, American Thoracic Society

    Dr A Brent Carter

  21. Macrophage Akt1 Kinase-Mediated Mitophagy Modulates Apoptosis Resistance and Pulmonary Fibrosis

    Article • Immunity, March 2016, Elsevier

    Dr A Brent Carter

  22. CaMKII inhibition in type II pneumocytes protects from bleomycin-induced pulmonary fibrosis by preventing Ca 2+ -dependent apoptosis

    Article • AJP Lung Cellular and Molecular Physiology, November 2015, American Physiological Society

    Dr A Brent Carter

  23. Targeting the isoprenoid pathway to abrogate progression of pulmonary fibrosis

    Article • Free Radical Biology and Medicine, September 2015, Elsevier

    Dr A Brent Carter

  24. Heme oxygenase-1-mediated autophagy protects against pulmonary endothelial cell death and development of emphysema in cadmium-treated mice

    Article • AJP Lung Cellular and Molecular Physiology, June 2015, American Physiological Society

    Dr A Brent Carter

  25. macrophage akt

    Article • The FASEB Journal, May 2015, Federation of American Societies For Experimental Biology (FASEB)

    Dr A Brent Carter

  26. The Metabolic Prospective and Redox Regulation of Macrophage Polarization

    Article • Journal of Clinical & Cellular Immunology, January 2015, OMICS Publishing Group

    Dr A Brent Carter

  27. Mitochondrial-Targeted Antioxidant Therapy Decreases Transforming Growth Factor-β–Mediated Collagen Production in a Murine Asthma Model

    Article • American Journal of Respiratory Cell and Molecular Biology, January 2015, American Thoracic Society

    Dr A Brent Carter

  28. Modulation of the Mevalonate Pathway by Akt Regulates Macrophage Survival and Development of Pulmonary Fibrosis

    Article • Journal of Biological Chemistry, November 2014, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr A Brent Carter

  29. Asbestos-induced Disruption of Calcium Homeostasis Induces Endoplasmic Reticulum Stress in Macrophages

    Article • Journal of Biological Chemistry, October 2014, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr A Brent Carter

  30. Acrolein-Exposed Normal Human Lung Fibroblasts in Vitro: Cellular Senescence, Enhanced Telomere Erosion, and Degradation of Werner’s Syndrome Protein

    Article • Environmental Health Perspectives, April 2014, Environmental Health Perspectives

    Dr A Brent Carter

  31. Accelerated Development of Pulmonary Fibrosis via Cu,Zn-superoxide Dismutase-induced Alternative Activation of Macrophages

    Article • Journal of Biological Chemistry, May 2013, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr A Brent Carter

  32. Redox Regulation of the Macrophage Phenotype Modulates Pulmonary Fibrosis

    Article • Free Radical Biology and Medicine, November 2012, Elsevier

    Dr A Brent Carter

  33. Expression of Human Paraoxonase 1 Decreases Superoxide Levels and Alters Bacterial Colonization in the Gut of Drosophila melanogaster

    Article • PLoS ONE, August 2012, PLOS

    Dr A Brent Carter

  34. SP-1 regulation of MMP-9 expression requires Ser 586 in the PEST domain

    Article • Biochemical Journal, July 2012, Portland Press Ltd.

    Dr A Brent Carter

  35. The multifunctional Ca2+/calmodulin-dependent kinase II regulates vascular smooth muscle migration through matrix metalloproteinase 9

    Article • AJP Heart and Circulatory Physiology, May 2012, American Physiological Society

    Dr A Brent Carter

  36. Cu,Zn-SOD-Induced H2O2 Mediates Pulmonary Fibrosis Via Alternative Activation Of Macrophages

    Article • May 2012, American Thoracic Society

    Dr A Brent Carter

  37. Mitochondrial Rac1 GTPase Import and Electron Transfer from CytochromecAre Required for Pulmonary Fibrosis

    Article • Journal of Biological Chemistry, December 2011, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr A Brent Carter

  38. Cu,Zn-SOD Induces Pulmonary Fibrosis via Alternatively Activation of Macrophages

    Article • Free Radical Biology and Medicine, November 2011, Elsevier

    Dr A Brent Carter

  39. Cu,Zn-SOD Down-regulates MMP-9 Expression Via Inhibition Of ERK

    Article • May 2011, American Thoracic Society

    Dr A Brent Carter

  40. Mitochondrial Cu,Zn-Superoxide Dismutase Mediates Pulmonary Fibrosis by Augmenting H 2 O 2 Generation

    Article • Journal of Biological Chemistry, March 2011, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr A Brent Carter

  41. Nuclear factor kappa B–dependent gene transcription in cholecystokinin- and tumor necrosis factor-α–stimulated isolated acinar cells is regulated by p38 mitogen-activated protein kinase

    Article • The American Journal of Surgery, August 2010, Elsevier

    Dr A Brent Carter

  42. Rac1-mediated Mitochondrial H2O2Generation RegulatesMMP-9Gene Expression in Macrophages via Inhibition of SP-1 and AP-1

    Article • Journal of Biological Chemistry, June 2010, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr A Brent Carter

  43. Overexpression Of Cu,Zn-SOD Augments Proinflammatory Cytokines Gene Expression Via Mitochondrial H2O2 Generation

    Article • May 2010, American Thoracic Society

    Dr A Brent Carter

  44. Cu,Zn-SOD-induced H2O2 Mediates Pulmonary Fibrosis via Down-regulation of ERK

    Article • Free Radical Biology and Medicine, January 2010, Elsevier

    Dr A Brent Carter

  45. Modulation of reactive oxygen species by Rac1 or catalase prevents asbestos-induced pulmonary fibrosis

    Article • AJP Lung Cellular and Molecular Physiology, November 2009, American Physiological Society

    Dr A Brent Carter

  46. 15-Deoxy-Δ12,14-prostaglandin J2Impairs Phosphatidylcholine Synthesis and Induces Nuclear Accumulation of Thiol-modified Cytidylyltransferase

    Article • Journal of Biological Chemistry, July 2008, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr A Brent Carter

  47. The Nalp3 inflammasome is essential for the development of silicosis

    Article • Proceedings of the National Academy of Sciences, July 2008, Proceedings of the National Academy of Sciences

    Dr A Brent Carter

  48. Asbestos-Induced MKP-3 Expression Augments TNF-α Gene Expression in Human Monocytes

    Article • American Journal of Respiratory Cell and Molecular Biology, July 2008, American Thoracic Society

    Dr A Brent Carter

  49. Enteral Exclusion Increases Map Kinase Activation and Cytokine Production in a Model of Gallstone Pancreatitis

    Article • Pancreatology, April 2008, Elsevier

    Dr A Brent Carter

  50. Constitutive NADPH oxidase and increased mitochondrial respiratory chain activity regulate chemokine gene expression

    Article • AJP Lung Cellular and Molecular Physiology, November 2007, American Physiological Society

    Dr A Brent Carter

  51. Differential Expression and Oxidation of MKP-1 Modulates TNF-α Gene Expression

    Article • American Journal of Respiratory Cell and Molecular Biology, September 2007, American Thoracic Society

    Dr A Brent Carter

  52. Regulation of normal cell cycle progression by flavin-containing oxidases

    Article • Oncogene, July 2007, Springer Science + Business Media

    Dr A Brent Carter

  53. Oxysterols Inhibit Phosphatidylcholine Synthesis via ERK Docking and Phosphorylation of CTP:Phosphocholine Cytidylyltransferase

    Article • Journal of Biological Chemistry, March 2005, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr A Brent Carter

  54. High Levels of Catalase and Glutathione Peroxidase Activity Dampen H2O2Signaling in Human Alveolar Macrophages

    Article • American Journal of Respiratory Cell and Molecular Biology, July 2004, American Thoracic Society

    Dr A Brent Carter

  55. Respiratory Syncytial Virus Up-regulates TLR4 and Sensitizes Airway Epithelial Cells to Endotoxin

    Article • Journal of Biological Chemistry, October 2003, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr A Brent Carter

  56. Phosphatidylinositol 3-Kinase Activity Negatively Regulates Stability of Cyclooxygenase 2 mRNA

    Article • Journal of Biological Chemistry, June 2002, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr A Brent Carter

  57. Oxidant-Mediated Increases in Redox Factor-1 Nuclear Protein and Activator Protein-1 DNA Binding in Asbestos-Treated Macrophages

    Article • The Journal of Immunology, June 2002, The American Association of Immunologists

    Dr A Brent Carter

  58. Ceramide Regulates Lipopolysaccharide-Induced Phosphatidylinositol 3-Kinase and Akt Activity in Human Alveolar Macrophages

    Article • The Journal of Immunology, November 2001, The American Association of Immunologists

    Dr A Brent Carter

  59. Respiratory Syncytial Virus Inhibits Apoptosis and Induces NF-κB Activity through a Phosphatidylinositol 3-Kinase-dependent Pathway

    Article • Journal of Biological Chemistry, October 2001, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr A Brent Carter

  60. GM-CSF Increases AP-1 DNA Binding and Ref-1 Amounts in Human Alveolar Macrophages

    Article • American Journal of Respiratory Cell and Molecular Biology, August 2001, American Thoracic Society

    Dr A Brent Carter

  61. The Absence of Activator Protein 1-dependent Gene Expression in THP-1 Macrophages Stimulated with Phorbol Esters Is Due to Lack of p38 Mitogen-activated Protein Kinase Activation

    Article • Journal of Biological Chemistry, July 2001, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr A Brent Carter

  62. Lipopolysaccharide Activates Akt in Human Alveolar Macrophages Resulting in Nuclear Accumulation and Transcriptional Activity of  -Catenin

    Article • The Journal of Immunology, April 2001, The American Association of Immunologists

    Dr A Brent Carter

  63. Protein Kinase C   Plays a Central Role in Activation of the p42/44 Mitogen-Activated Protein Kinase by Endotoxin in Alveolar Macrophages

    Article • The Journal of Immunology, October 2000, The American Association of Immunologists

    Dr A Brent Carter

  64. ACTIVATION OF ERK2 BY RESPIRATORY SYNCYTIAL VIRUS IN A549 CELLS IS LINKED TO THE PRODUCTION OF INTERLEUKIN 8

    Article • Experimental Lung Research, January 2000, Taylor & Francis

    Dr A Brent Carter

  65. The p38 Mitogen-activated Protein Kinase Is Required for NF-κB-dependent Gene Expression

    Article • Journal of Biological Chemistry, October 1999, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr A Brent Carter

  66. THERAPY FOR VENTILATOR-ASSOCIATED PNEUMONIA

    Article • Clinics in Chest Medicine, September 1999, Elsevier

    Dr A Brent Carter

  67. Human Alveolar Macrophages Are Markedly Deficient in REF-1 and AP-1 DNA Binding Activity

    Article • Journal of Biological Chemistry, June 1999, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr A Brent Carter

  68. Both Erk and p38 Kinases Are Necessary for Cytokine Gene Transcription

    Article • American Journal of Respiratory Cell and Molecular Biology, April 1999, American Thoracic Society

    Dr A Brent Carter

  69. TNF-α increases ceramide without inducing apoptosis in alveolar type II epithelial cells

    Article • AJP Lung Cellular and Molecular Physiology, March 1999, American Physiological Society

    Dr A Brent Carter

  70. Changes in PKC isoforms in human alveolar macrophages compared with blood monocytes

    Article • AJP Lung Cellular and Molecular Physiology, August 1998, American Physiological Society

    Dr A Brent Carter

  71. Lipopolysaccharide-induced NF- κ B Activation and Cytokine Release in Human Alveolar Macrophages Is PKC-independent and TK- and PC-PLC-dependent

    Article • American Journal of Respiratory Cell and Molecular Biology, March 1998, American Thoracic Society

    Dr A Brent Carter

  72. Massive Pleural Effusion in Diffuse Granulomatous Disease

    Article • CHEST Journal, July 1997, Elsevier

    Dr A Brent Carter