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  1. Synthesis, biological evaluation, in silico modeling and crystallization of novel small monocationic molecules with potent antiproliferative activity by dual mechanism

    Article • European Journal of Medicinal Chemistry, December 2020, Elsevier

    Professor LUISA CARLOTA LOPEZ-CARA

  2. Crystal Structure of the Apo and the ADP-Bound Form of Choline Kinase from Plasmodium falciparum

    Article • Crystals, July 2020, MDPI AG

    Professor LUISA CARLOTA LOPEZ-CARA

  3. Targeting Aryl hydrocarbon receptor for next-generation immunotherapies: Selective modulators (SAhRMs) versus rapidly metabolized ligands (RMAhRLs)

    Article • European Journal of Medicinal Chemistry, January 2020, Elsevier

    Professor LUISA CARLOTA LOPEZ-CARA

  4. Biomimetic Magnetic Nanocarriers Drive Choline Kinase Alpha Inhibitor inside Cancer Cells for Combined Chemo-Hyperthermia Therapy

    Article • Pharmaceutics, August 2019, MDPI AG

    Professor LUISA CARLOTA LOPEZ-CARA

  5. Choline kinase inhibitors EB-3D and EB-3P interferes with lipid homeostasis in HepG2 cells

    Article • Scientific Reports, March 2019, Springer Science + Business Media

    Professor LUISA CARLOTA LOPEZ-CARA

  6. Design, Synthesis, and Biological Evaluation of 6-Substituted Thieno[3,2-d]pyrimidine Analogues as Dual Epidermal Growth Factor Receptor Kinase and Microtubule Inhibitors

    Article • Journal of Medicinal Chemistry, January 2019, American Chemical Society (ACS)

    Professor LUISA CARLOTA LOPEZ-CARA

  7. Choline Kinase Alpha Inhibition by EB-3D Triggers Cellular Senescence, Reduces Tumor Growth and Metastatic Dissemination in Breast Cancer

    Article • Cancers, October 2018, MDPI AG

    Professor LUISA CARLOTA LOPEZ-CARA

  8. EB-3D a novel choline kinase inhibitor induces deregulation of the AMPK-mTOR pathway and apoptosis in leukemia T-cells

    Article • Biochemical Pharmacology, September 2018, Elsevier

    Professor LUISA CARLOTA LOPEZ-CARA

  9. 1,2-Diphenoxiethane salts as potent antiplasmodial agents

    Article • Bioorganic & Medicinal Chemistry Letters, August 2018, Elsevier

    Professor LUISA CARLOTA LOPEZ-CARA

  10. Enhancement of Tumor Cell Death by Combining gef Gene Mediated Therapy and New 1,4-Benzoxazepin-2,6-Dichloropurine Derivatives in Breast Cancer Cells

    Article • Frontiers in Pharmacology, July 2018, Frontiers

    Professor LUISA CARLOTA LOPEZ-CARA

  11. Lead optimization-hit expansion of new asymmetrical pyridinium/quinolinium compounds as choline kinase α1 inhibitors

    Article • Future Medicinal Chemistry, July 2018, Future Science

    Professor LUISA CARLOTA LOPEZ-CARA

  12. Synthesis and biological evaluation of alpha-bromoacryloylamido indolyl pyridinyl propenones as potent apoptotic inducers in human leukaemia cells

    Article • Journal of Enzyme Inhibition and Medicinal Chemistry, January 2018, Taylor & Francis

    Francisco Estévez, Professor LUISA CARLOTA LOPEZ-CARA

  13. 2-Alkoxycarbonyl-3-arylamino-5-substituted thiophenes as a novel class of antimicrotubule agents: Design, synthesis, cell growth and tubulin polymerization inhibition

    Article • European Journal of Medicinal Chemistry, January 2018, Elsevier

    Professor LUISA CARLOTA LOPEZ-CARA

  14. Design, synthesis and biological evaluation of 3-substituted-2-oxindole hybrid derivatives as novel anticancer agents

    Article • European Journal of Medicinal Chemistry, July 2017, Elsevier

    Professor LUISA CARLOTA LOPEZ-CARA

  15. Synthesis and Biological Evaluation of 2-Methyl-4,5-Disubstituted Oxazoles as a Novel Class of Highly Potent Antitubulin Agents

    Article • Scientific Reports, April 2017, Nature

    Professor LUISA CARLOTA LOPEZ-CARA

  16. 1 H and 13 C NMR spectral assignments of 1,1′-(((ethane-1,2-diylbis(oxy))bis(4,1-phenylene))bis(methylene))-bispyridinium and -bisquinolinium bromide derivatives

    Article • Magnetic Resonance in Chemistry, July 2016, Wiley

    Professor LUISA CARLOTA LOPEZ-CARA

  17. Design and Synthesis of Potent in Vitro and in Vivo Anticancer Agents Based on 1-(3′,4′,5′-Trimethoxyphenyl)-2-Aryl-1H-Imidazole

    Article • Scientific Reports, May 2016, Nature

    Professor LUISA CARLOTA LOPEZ-CARA

  18. Synthesis of oxadiazoline and quinazolinone derivatives and their biological evaluation as nitric oxide synthase inhibitors

    Article • Medicinal Chemistry Research, April 2016, Springer Science + Business Media

    Professor LUISA CARLOTA LOPEZ-CARA

  19. Design, synthesis, crystallization and biological evaluation of new symmetrical biscationic compounds as selective inhibitors of human Choline Kinase α1 (ChoKα1)

    Article • Scientific Reports, March 2016, Nature

    Professor LUISA CARLOTA LOPEZ-CARA

  20. Novel iodoacetamido benzoheterocyclic derivatives with potent antileukemic activity are inhibitors of STAT5 phosphorylation

    Article • European Journal of Medicinal Chemistry, January 2016, Elsevier

    Professor LUISA CARLOTA LOPEZ-CARA

  21. Synthesis and biological evaluation of a new series of 2-amino-3-aroyl thiophene derivatives as agonist allosteric modulators of the A1 adenosine receptor. A position-dependent effect study

    Article • European Journal of Medicinal Chemistry, August 2015, Elsevier

    Professor LUISA CARLOTA LOPEZ-CARA

  22. Pharmacophore-Based Virtual Screening to Discover New Active Compounds for Human Choline Kinase α1

    Article • Molecular Informatics, June 2015, Wiley

    ANTONIO MACCHIARULO, Professor LUISA CARLOTA LOPEZ-CARA

  23. Design, Synthesis, in Vitro, and in Vivo Anticancer and Antiangiogenic Activity of Novel 3-Arylaminobenzofuran Derivatives Targeting the Colchicine Site on Tubulin

    Article • Journal of Medicinal Chemistry, March 2015, American Chemical Society (ACS)

    Professor LUISA CARLOTA LOPEZ-CARA

  24. New more polar symmetrical bipyridinic compounds: new strategy for the inhibition of choline kinase α1

    Article • Future Medicinal Chemistry, March 2015, Future Science

    Professor LUISA CARLOTA LOPEZ-CARA

  25. Representaciones sociales de los estudiantes sobre el trabajo docente

    Article • Infancias Imágenes, December 2014, Universidad Distrital Francisco Jose de Caldas

    Professor LUISA CARLOTA LOPEZ-CARA

  26. Synthesis and Biological Evaluation of Novel Allosteric Enhancers of the A1Adenosine Receptor Based on 2-Amino-3-(4′-Chlorobenzoyl)-4-Substituted-5-Arylethynyl Thiophene

    Article • Journal of Medicinal Chemistry, September 2014, American Chemical Society (ACS)

    Professor LUISA CARLOTA LOPEZ-CARA

  27. Design, synthesis and biological evaluation of 3,5-disubstituted 2-amino thiophene derivatives as a novel class of antitumor agents

    Article • Bioorganic & Medicinal Chemistry, September 2014, Elsevier

    Professor LUISA CARLOTA LOPEZ-CARA

  28. Synthesis and biological evaluation of novel 2-amino-3-aroyl-4-neopentyl-5-substituted thiophene derivatives as allosteric enhancers of the A1 adenosine receptor

    Article • Bioorganic & Medicinal Chemistry, January 2014, Elsevier

    Professor LUISA CARLOTA LOPEZ-CARA

  29. Concise Synthesis and Biological Evaluation of 2-Aroyl-5-Amino Benzo[b]thiophene Derivatives As a Novel Class of Potent Antimitotic Agents

    Article • Journal of Medicinal Chemistry, November 2013, American Chemical Society (ACS)

    Professor LUISA CARLOTA LOPEZ-CARA

  30. New non-symmetrical choline kinase inhibitors

    Article • Bioorganic & Medicinal Chemistry, November 2013, Elsevier

    Professor LUISA CARLOTA LOPEZ-CARA

  31. 1H,13C NMR studies of new 3-aminophenol isomers linked to pyridinium salts

    Article • Magnetic Resonance in Chemistry, October 2013, Wiley

    Professor LUISA CARLOTA LOPEZ-CARA

  32. Synthesis and biological effects of novel 2-amino-3-(4-chlorobenzoyl)-4-substituted thiophenes as allosteric enhancers of the A1 adenosine receptor

    Article • European Journal of Medicinal Chemistry, September 2013, Elsevier

    Professor LUISA CARLOTA LOPEZ-CARA

  33. Synthesis and Biological Evaluation of 2-Amino-3-(4-chlorobenzoyl)-4-[(4-arylpiperazin-1-yl)methyl]-5-substituted-thiophenes. Effect of the 5-Modification on Allosteric Enhancer Activity at the A1Adenosine Receptor

    Article • Journal of Medicinal Chemistry, September 2012, American Chemical Society (ACS)

    Professor LUISA CARLOTA LOPEZ-CARA

  34. NMR spectroscopic characterization of new 2,3-dihydro-1,3,4-thiadiazole derivatives

    Article • Magnetic Resonance in Chemistry, June 2012, Wiley

    Professor LUISA CARLOTA LOPEZ-CARA

  35. 1,3,4-Thiadiazole derivatives as selective inhibitors of iNOS versus nNOS: Synthesis and structure-activity dependence

    Article • European Journal of Medicinal Chemistry, April 2012, Elsevier

    Professor LUISA CARLOTA LOPEZ-CARA

  36. In silico pharmacology for a multidisciplinary drug discovery process

    Article • Drug Metabolism and Drug Interactions, January 2012, De Gruyter

    Professor LUISA CARLOTA LOPEZ-CARA

  37. Calidad de vida en pacientes con disfunción eréctil

    Article • Revista Internacional de Andrología, January 2012, Elsevier

    Professor LUISA CARLOTA LOPEZ-CARA

  38. Structure–activity relationships of 2-amino-3-aroyl-4-[(4-arylpiperazin-1-yl)methyl]thiophenes. Part 2: Probing the influence of diverse substituents at the phenyl of the arylpiperazine moiety on allosteric enhancer activity at the A1 adenosine receptor

    Article • Bioorganic & Medicinal Chemistry, January 2012, Elsevier

    Professor LUISA CARLOTA LOPEZ-CARA

  39. One-pot synthesis and biological evaluation of 2-pyrrolidinyl-4-amino-5-(3′,4′,5′-trimethoxybenzoyl)thiazole: A unique, highly active antimicrotubule agent

    Article • European Journal of Medicinal Chemistry, December 2011, Elsevier

    Professor LUISA CARLOTA LOPEZ-CARA

  40. Disfunción eréctil asociada a factores de riesgo cardiovascular

    Article • Clínica e Investigación en Arteriosclerosis, November 2011, Elsevier

    Professor LUISA CARLOTA LOPEZ-CARA

  41. Synthesis and Antitumor Molecular Mechanism of Agents Based on Amino 2-(3′,4′,5′-Trimethoxybenzoyl)benzo[b]furan: Inhibition of Tubulin and Induction of Apoptosis

    Article • ChemMedChem, August 2011, Wiley

    Professor LUISA CARLOTA LOPEZ-CARA

  42. ChemInform Abstract: Synthesis and Biological Evaluation of 2-(3′,4′,5′-Trimethoxybenzoyl)-3-aryl/arylaminobenzo[b]thiophene Derivatives as a Novel Class of Antiproliferative Agents.

    Article • ChemInform, March 2011, Wiley

    Professor LUISA CARLOTA LOPEZ-CARA

  43. New (RS)-benzoxazepin-purines with antitumour activity: The chiral switch from (RS)-2,6-dichloro-9-[1-(p-nitrobenzenesulfonyl)-1,2,3,5-tetrahydro-4,1-benzoxazepin-3-yl]-9H-purine

    Article • European Journal of Medicinal Chemistry, January 2011, Elsevier

    Professor LUISA CARLOTA LOPEZ-CARA

  44. Synthesis and biological evaluation of 2-(3′,4′,5′-trimethoxybenzoyl)-3-aryl/arylaminobenzo[b]thiophene derivatives as a novel class of antiproliferative agents

    Article • European Journal of Medicinal Chemistry, December 2010, Elsevier

    Professor LUISA CARLOTA LOPEZ-CARA

  45. Synthesis and Evaluation of Haloacetyl, α-Bromoacryloyl and Nitrooxyacetyl Benzo[b]furan and Benzo[b]thiophene Derivatives as Potent Antiproliferative Agents Against Leukemia L1210 and K562 Cells

    Article • Letters in Drug Design & Discovery, August 2010, Bentham Science Publishers

    Professor LUISA CARLOTA LOPEZ-CARA

  46. Synthesis and Antitumor Activity of 1,5-Disubstituted 1,2,4-Triazoles as Cis-Restricted Combretastatin Analogues

    Article • Journal of Medicinal Chemistry, May 2010, American Chemical Society (ACS)

    Professor LUISA CARLOTA LOPEZ-CARA

  47. Symmetrical α-bromoacryloylamido diaryldienone derivatives as a novel series of antiproliferative agents. Design, synthesis and biological evaluation

    Article • Bioorganic & Medicinal Chemistry Letters, May 2010, Elsevier

    Professor LUISA CARLOTA LOPEZ-CARA

  48. Synthesis and evaluation of a thio analogue of duocarmycin SA

    Article • Bioorganic & Medicinal Chemistry Letters, December 2009, Elsevier

    Professor LUISA CARLOTA LOPEZ-CARA

  49. NMR and conformational studies of new 5-phenylpyrrole-carboxamide derivatives

    Article • Magnetic Resonance in Chemistry, October 2009, Wiley

    Professor LUISA CARLOTA LOPEZ-CARA

  50. Design, synthesis and structure–activity relationship of 2-(3′,4′,5′-trimethoxybenzoyl)-benzo[b]furan derivatives as a novel class of inhibitors of tubulin polymerization

    Article • Bioorganic & Medicinal Chemistry, October 2009, Elsevier

    Professor LUISA CARLOTA LOPEZ-CARA

  51. 2-Arylamino-4-Amino-5-Aroylthiazoles. “One-Pot” Synthesis and Biological Evaluation of a New Class of Inhibitors of Tubulin Polymerization

    Article • Journal of Medicinal Chemistry, September 2009, American Chemical Society (ACS)

    Professor LUISA CARLOTA LOPEZ-CARA

  52. Validity of tests performed to diagnose acute abdominal pain in patients admitted at an emergency department

    Article • Revista Española de Enfermedades Digestivas, September 2009, Instituto de Salud Carlos III/BNCS/SciELO Espana

    Professor LUISA CARLOTA LOPEZ-CARA

  53. Discovery of 8-methoxypyrazino[1,2-a]indole as a New Potent Antiproliferative Agent Against Human Leukemia K562 Cells. A Structure-Activity Relationship Study

    Article • Letters in Drug Design & Discovery, June 2009, Bentham Science Publishers

    Professor LUISA CARLOTA LOPEZ-CARA

  54. Phenylpyrrole derivatives as neural and inducible nitric oxide synthase (nNOS and iNOS) inhibitors

    Article • European Journal of Medicinal Chemistry, June 2009, Elsevier

    Professor LUISA CARLOTA LOPEZ-CARA

  55. Hybrid α-bromoacryloylamido chalcones. Design, synthesis and biological evaluation

    Article • Bioorganic & Medicinal Chemistry Letters, April 2009, Elsevier

    Professor LUISA CARLOTA LOPEZ-CARA

  56. α-Halogenoacrylic Derivatives of Antitumor Agents

    Article • Mini-Reviews in Medicinal Chemistry, January 2009, Bentham Science Publishers

    Professor LUISA CARLOTA LOPEZ-CARA

  57. Synthesis and Biological Evaluation of 2-aroyl-4-phenyl-5- hydroxybenzofurans as a New Class of Antitubulin Agents

    Article • Medicinal Chemistry, November 2008, Bentham Science Publishers

    Professor LUISA CARLOTA LOPEZ-CARA

  58. Pyrazoles and pyrazolines as neural and inducible nitric oxide synthase (nNOS and iNOS) potential inhibitors (III)

    Article • European Journal of Medicinal Chemistry, November 2008, Elsevier

    Professor LUISA CARLOTA LOPEZ-CARA

  59. Synthesis and Biological Evaluation of 2-Amino-3-(4-Chlorobenzoyl)-4-[N-(Substituted) Piperazin-1-yl]Thiophenes as Potent Allosteric Enhancers of the A1Adenosine Receptor

    Article • Journal of Medicinal Chemistry, September 2008, American Chemical Society (ACS)

    Professor LUISA CARLOTA LOPEZ-CARA

  60. Synthesis and biological evaluation of 2-(3′,4′,5′-trimethoxybenzoyl)-3-N,N-dimethylamino benzo[b]furan derivatives as inhibitors of tubulin polymerization

    Article • Bioorganic & Medicinal Chemistry, September 2008, Elsevier

    Professor LUISA CARLOTA LOPEZ-CARA

  61. Synthesis and biological evaluation of 2-amino-3-(3′,4′,5′-trimethoxybenzoyl)-6-substituted-4,5,6,7-tetrahydrothieno[2,3-c]pyridine derivatives as antimitotic agents and inhibitors of tubulin polymerization

    Article • Bioorganic & Medicinal Chemistry Letters, September 2008, Elsevier

    Professor LUISA CARLOTA LOPEZ-CARA

  62. 1 H, 13 C NMR, X-ray and conformational studies of new 1-alkyl-3-benzoyl-pyrazole and 1-alkyl-3-benzoyl-pyrazoline derivatives

    Article • Magnetic Resonance in Chemistry, June 2008, Wiley

    Professor LUISA CARLOTA LOPEZ-CARA

  63. Design, synthesis, and biological evaluation of thiophene analogues of chalcones

    Article • Bioorganic & Medicinal Chemistry, May 2008, Elsevier

    Professor LUISA CARLOTA LOPEZ-CARA

  64. The P2X7receptor as a therapeutic target

    Article • Expert Opinion on Therapeutic Targets, April 2008, Informa Healthcare

    Professor LUISA CARLOTA LOPEZ-CARA

  65. Synthesis and Biological Evaluation of a Series of 2-(3,4,5-Trimethoxybenzoyl)-Indol-3-yl Acetic Acid Derivatives as Potential Agents against Human Leukemia K562 Cells

    Article • Letters in Drug Design & Discovery, April 2008, Bentham Science Publishers

    Professor LUISA CARLOTA LOPEZ-CARA

  66. Synthesis and Biological Evaluation of 1-Methyl-2-(3′,4′,5′-trimethoxybenzoyl)-3-aminoindoles as a New Class of Antimitotic Agents and Tubulin Inhibitors

    Article • Journal of Medicinal Chemistry, March 2008, American Chemical Society (ACS)

    Professor LUISA CARLOTA LOPEZ-CARA

  67. Synthesis and Biological Evaluation of 2-amino-3-(3, 4, 5-trimethoxyphenylsulfonyl)-5-aryl thiophenes as a New Class of Antitubulin Agents

    Article • Medicinal Chemistry, November 2007, Bentham Science Publishers

    Professor LUISA CARLOTA LOPEZ-CARA

  68. Microwave-Assisted Synthesis of Substituted 2,4-Diarylthiazoles and their Evaluation as Anticancer Agents

    Article • Letters in Drug Design & Discovery, October 2007, Bentham Science Publishers

    Professor LUISA CARLOTA LOPEZ-CARA

  69. From Tyrosine to Glycine:  Synthesis and Biological Activity of Potent Antagonists of the Purinergic P2X7Receptor

    Article • Journal of Medicinal Chemistry, July 2007, American Chemical Society (ACS)

    Professor LUISA CARLOTA LOPEZ-CARA

  70. Allosteric Enhancers for A1 Adenosine Receptor

    Article • Mini-Reviews in Medicinal Chemistry, June 2007, Bentham Science Publishers

    Professor LUISA CARLOTA LOPEZ-CARA

  71. Synthesis and Biological Evaluation of 2- and 3-Aminobenzo[b]thiophene Derivatives as Antimitotic Agents and Inhibitors of Tubulin Polymerization

    Article • Journal of Medicinal Chemistry, May 2007, American Chemical Society (ACS)

    Professor LUISA CARLOTA LOPEZ-CARA

  72. Synthesis and Biological Evaluation of Novel 1-Deoxy-1-[6-[((hetero)arylcarbonyl)hydrazino]- 9H-purin-9-yl]-N-ethyl-β-d-ribofuranuronamide Derivatives as Useful Templates for the Development of A2BAdenosine Receptor Agonists

    Article • Journal of Medicinal Chemistry, January 2007, American Chemical Society (ACS)

    Professor LUISA CARLOTA LOPEZ-CARA

  73. Microwave-assisted synthesis of thieno[2,3-c]pyridine derivatives as a new series of allosteric enhancers at the adenosine A1 receptor

    Article • Bioorganic & Medicinal Chemistry Letters, November 2006, Elsevier

    Professor LUISA CARLOTA LOPEZ-CARA

  74. Synthesis and Biological Evaluation of 2-(3‘,4‘,5‘-Trimethoxybenzoyl)-3-Amino 5-Aryl Thiophenes as a New Class of Tubulin Inhibitors

    Article • Journal of Medicinal Chemistry, October 2006, American Chemical Society (ACS)

    Professor LUISA CARLOTA LOPEZ-CARA

  75. An unexpected aromatization during the N-alkylation reaction of 3,4-dihydro-1H-pyrazole derivatives: insight into the reaction mechanism

    Article • Tetrahedron Letters, August 2006, Elsevier

    Professor LUISA CARLOTA LOPEZ-CARA

  76. Constipation in the population over 50 years of age in Albacete province

    Article • Revista Española de Enfermedades Digestivas, June 2006, Instituto de Salud Carlos III/BNCS/SciELO Espana

    Professor LUISA CARLOTA LOPEZ-CARA

  77. Kynurenamines as Neural Nitric Oxide Synthase Inhibitors

    Article • Journal of Medicinal Chemistry, December 2005, American Chemical Society (ACS)

    Professor LUISA CARLOTA LOPEZ-CARA

  78. Synthesis and Biological Evaluation of Allosteric A1-Adenosine Receptor Modulators Structurally Related to (2-Amino-4,5,6,7-Tetrahydro-Benzo[B]Thiophen-3-YL)-(4-Chloro-Phenyl)-Methanone, a Potent Compound Useful to Reduce Neuropathic Pain

    Article • Medicinal Chemistry Research, April 2005, Springer Science + Business Media

    Professor LUISA CARLOTA LOPEZ-CARA

  79. A pharmacoeconomic evaluation of statins in the treatment of hypercholesterolaemia in the primary care setting in Spain

    Article • PharmacoEconomics, March 2005, Springer Science + Business Media

    Professor LUISA CARLOTA LOPEZ-CARA

  80. Structural elucidation of a new Δ2-pyrazoline derivatives using1H and13C NMR spectroscopy

    Article • Magnetic Resonance in Chemistry, January 2005, Wiley

    Professor LUISA CARLOTA LOPEZ-CARA