All Stories

  1. Prevention of Inflammation, Neovascularization, and Retinal Dysfunction by Kinin B1 Receptor Antagonism in a Mouse Model of Age-Related Macular Degeneration

    Article • Journal of Clinical Medicine, September 2023, MDPI AG

    Professor Réjean Couture

  2. Thymus atlanticus: A Source of Nutrients with Numerous Health Benefits and Important Therapeutic Potential for Age-Related Diseases

    Article • Nutrients, September 2023, MDPI AG

    Professor Réjean Couture

  3. Saffron (Crocus sativus L.): A Source of Nutrients for Health and for the Treatment of Neuropsychiatric and Age-Related Diseases

    Article • Nutrients, January 2022, MDPI AG

    Professor Réjean Couture

  4. Kinins and Their Receptors as Potential Therapeutic Targets in Retinal Pathologies

    Article • Cells, July 2021, MDPI AG

    Professor Réjean Couture

  5. Differential Expression of Kinin Receptors in Human Wet and Dry Age-Related Macular Degeneration Retinae

    Article • Pharmaceuticals, June 2020, MDPI AG

    Professor Réjean Couture

  6. Ligand‐specific recycling profiles determine distinct potential for chronic analgesic tolerance of delta‐opioid receptor (DOPr) agonists

    Article • Journal of Cellular and Molecular Medicine, April 2020, Wiley

    Professor Réjean Couture

  7. The effects of anti‐VEGF and kinin B1 receptor blockade on retinal inflammation in laser‐induced choroidal neovascularization

    Article • British Journal of Pharmacology, February 2020, Wiley

    Professor Réjean Couture

  8. Reciprocal Regulatory Interaction between TRPV1 and Kinin B1 Receptor in a Rat Neuropathic Pain Model

    Article • International Journal of Molecular Sciences, January 2020, MDPI AG

    Professor Réjean Couture

  9. Diabetes-Induced Inflammation and Vascular Alterations in the Goto–Kakizaki Rat Retina

    Article • Current Eye Research, January 2020, Taylor & Francis

    Professor Réjean Couture

  10. Beneficial Effects of Alpha-Lipoic Acid on Hypertension, Visceral Obesity, UCP-1 Expression and Oxidative Stress in Zucker Diabetic Fatty Rats

    Article • Antioxidants, December 2019, MDPI AG

    Professor Réjean Couture

  11. Tibial post fracture pain is reduced in kinin receptors deficient mice and blunted by kinin receptor antagonists

    Article • Journal of Translational Medicine, October 2019, Springer Science + Business Media

    Professor Réjean Couture

  12. Profiling of how nociceptor neurons detect danger – new and old foes

    Article • Journal of Internal Medicine, July 2019, Wiley

    Professor Réjean Couture

  13. Bradykinin Type 1 Receptor – Inducible Nitric Oxide Synthase: A New Axis Implicated in Diabetic Retinopathy

    Article • Frontiers in Pharmacology, March 2019, Frontiers

    Professor Réjean Couture

  14. Neurons and Microglia; A Sickly-Sweet Duo in Diabetic Pain Neuropathy

    Article • Frontiers in Neuroscience, January 2019, Frontiers

    Professor Réjean Couture

  15. Oxidative Stress: Neuropathy, Excitability, and Neurodegeneration

    Article • Oxidative Medicine and Cellular Longevity, January 2019, Hindawi Publishing Corporation

    Professor Réjean Couture

  16. Expression, distribution and function of kinin B1 receptor in the rat diabetic retina

    Article • British Journal of Pharmacology, February 2018, Wiley

    Professor Réjean Couture

  17. Argan Oil as an Effective Nutri-Therapeutic Agent in Metabolic Syndrome: A Preclinical Study

    Article • International Journal of Molecular Sciences, November 2017, MDPI AG

    Joseph Haddad, Professor Réjean Couture

  18. Localization and Interaction between Kinin B1 Receptor and NADPH Oxidase in the Vascular System of Diabetic Rats

    Article • Frontiers in Physiology, October 2017, Frontiers

    Joseph Haddad, Professor Réjean Couture

  19. Kininase 1 As a Preclinical Therapeutic Target for Kinin B1 Receptor in Insulin Resistance

    Article • Frontiers in Pharmacology, August 2017, Frontiers

    Joseph Haddad, Professor Réjean Couture

  20. Impact of pioglitazone and bradykinin type 1 receptor antagonist on type 2 diabetes in high-fat diet-fed C57BL/6J mice

    Article • Obesity Science & Practice, July 2017, Wiley

    Joseph Haddad, Professor Réjean Couture

  21. Primary Role for Kinin B1 and B2 Receptors in Glioma Proliferation

    Article • Molecular Neurobiology, November 2016, Springer Science + Business Media

    Professor Réjean Couture

  22. Beneficial effects of argan oil on blood pressure, insulin resistance, and oxidative stress in rat

    Article • Nutrition, October 2016, Elsevier

    Joseph Haddad, Professor Réjean Couture

  23. Beneficial effects of kinin B1 receptor antagonism on plasma fatty acid alterations and obesity in Zucker diabetic fatty rats

    Article • Canadian Journal of Physiology and Pharmacology, July 2016, Canadian Science Publishing

    Professor Réjean Couture

  24. Interplay between the kinin B1receptor and inducible nitric oxide synthase in insulin resistance

    Article • British Journal of Pharmacology, May 2016, Wiley

    Joseph Haddad, Professor Réjean Couture

  25. Contribution of adrenomedullin to the switch of G protein‐coupled μ‐opioid receptors from Gi to Gs in the spinal dorsal horn following chronic morphine exposure in rats

    Article • British Journal of Pharmacology, February 2016, Wiley

    Professor Réjean Couture

  26. Placental Underperfusion in a Rat Model of Intrauterine Growth Restriction Induced by a Reduced Plasma Volume Expansion

    Article • PLoS ONE, January 2016, PLOS

    Professor Réjean Couture

  27. Cellular localisation of the kinin B1R in the pancreas of streptozotocin-treated rat and the anti-diabetic effect of the antagonist SSR240612

    Article • Biological Chemistry, January 2016, De Gruyter

    Professor Réjean Couture

  28. Brain kinin B1 receptor is upregulated by the oxidative stress and its activation leads to stereotypic nociceptive behavior in insulin-resistant rats

    Article • Peptides, July 2015, Elsevier

    Professor Réjean Couture

  29. A primary role for kinin B1 receptor in inflammation, organ damage, and lethal thrombosis in a rat model of septic shock in diabetes

    Article • European Journal of Inflammation, April 2015, SAGE Publications

    Professor Réjean Couture

  30. Effects of Alpha-Lipoic Acid on Oxidative Stress and Kinin Receptor Expression in Obese Zucker Diabetic Fatty Rats

    Article • Journal of Diabetes & Metabolism, January 2015, OMICS Publishing Group

    Professor Réjean Couture

  31. Kinin Receptors in Vascular Biology and Pathology

    Article • Current Vascular Pharmacology, April 2014, Bentham Science Publishers

    Professor Réjean Couture

  32. Activated microglia in the spinal cord underlies diabetic neuropathic pain

    Article • European Journal of Pharmacology, April 2014, Elsevier

    Professor Réjean Couture

  33. The Kallikrein-Kinin System in Diabetic Retinopathy

    Article • January 2014, Springer Science + Business Media

    Professor Réjean Couture

  34. Activation of Mas oncogene-related gene (Mrg) C receptors enhances morphine-induced analgesia through modulation of coupling of μ-opioid receptor to Gi-protein in rat spinal dorsal horn

    Article • Neuroscience, December 2013, Elsevier

    Professor Réjean Couture

  35. Antioxidant/Oxidant Status and Cardiac Function in Bradykinin B1- and B2-Receptor Null Mice

    Article • Physiological Research, October 2013, Institute of Physiology of the Czech Academy of Sciences

    Professor Réjean Couture

  36. Bradykinin B2 receptors increase hippocampal excitability and susceptibility to seizures in mice

    Article • Neuroscience, September 2013, Elsevier

    Professor Réjean Couture

  37. Brain kinin B1 receptor contributes to the onset of stereotypic nocifensive behavior in rat

    Article • Behavioural Brain Research, March 2013, Elsevier

    Professor Réjean Couture

  38. Cognitive and cerebrovascular improvements following kinin B1 receptor blockade in Alzheimer’s disease mice

    Article • Journal of Neuroinflammation, January 2013, Springer Science + Business Media

    Dr Baptiste Lacoste, Professor Réjean Couture

  39. Assessment of Retinal and Choroidal Blood Flow Changes Using Laser Doppler Flowmetry in Rats

    Article • Current Eye Research, September 2012, Taylor & Francis

    Professor Réjean Couture

  40. Activation of kinin B1 receptor evokes hyperthermia through a vagal sensory mechanism in the rat

    Article • Journal of Neuroinflammation, September 2012, Springer Science + Business Media

    Professor Réjean Couture

  41. Bradykinin inhibits high glucose- and growth factor-induced collagen synthesis in mesangial cells through the B2-kinin receptor

    Article • AJP Renal Physiology, July 2012, American Physiological Society

    Professor Réjean Couture

  42. Emerging role of microglial kinin B1 receptor in diabetic pain neuropathy

    Article • Experimental Neurology, April 2012, Elsevier

    Professor Réjean Couture

  43. Ocular Application of the Kinin B1 Receptor Antagonist LF22-0542 Inhibits Retinal Inflammation and Oxidative Stress in Streptozotocin-Diabetic Rats

    Article • PLoS ONE, March 2012, PLOS

    Professor Réjean Couture

  44. An ex vivo approach to the differential parenchymal responses induced by cigarette whole smoke and its vapor phase

    Article • Toxicology, March 2012, Elsevier

    Professor Réjean Couture

  45. Activation of TRPV1 by capsaicin induces functional Kinin B1 receptor in rat spinal cord microglia

    Article • Journal of Neuroinflammation, January 2012, Springer Science + Business Media

    Professor Réjean Couture

  46. Blockade of kinin B1 receptor reverses plasma fatty acids composition changes and body and tissue fat gain in a rat model of insulin resistance

    Article • Diabetes Obesity and Metabolism, November 2011, Wiley

    Professor Réjean Couture