All Stories

  1. All-photonic kinase inhibitors: light-controlled release-and-report inhibition
  2. Fluorescent Molecular Photoswitches for the Generation of All‐Optical Encryption Keys
  3. Exploration of Novel Urolithin C Derivatives as Non-Competitive Inhibitors of Liver Pyruvate Kinase
  4. Tuning liver pyruvate kinase activity up or down with a new class of allosteric modulators
  5. Ellagic Acid and Its Metabolites as Potent and Selective Allosteric Inhibitors of Liver Pyruvate Kinase
  6. Development of Dicationic Bisguanidine-Arylfuran Derivatives as Potent Agents against Gram-Negative Bacteria
  7. Design and development of photoswitchable DFG-Out RET kinase inhibitors
  8. Environmentally friendly catechol-based synthesis of dibenzosultams
  9. A Genetic Trap in Yeast for Inhibitors of SARS-CoV-2 Main Protease
  10. Bacterial glycyl tRNA synthetase offers glimpses of ancestral protein topologies
  11. A Small Molecule Targeting Human MEK1/2 Enhances ERK and p38 Phosphorylation under Oxidative Stress or with Phenothiazines
  12. Discovery of Functional Alternatively Spliced PKM Transcripts in Human Cancers
  13. Design and development of a photoswitchable DFG-out kinase inhibitor
  14. Peroxiredoxin promotes longevity and H2O2-resistance in yeast through redox-modulation of protein kinase A
  15. Getting DNA and RNA out of the dark with 2CNqA: a bright adenine analogue and interbase FRET donor
  16. A Redox-Sensitive Thiol in Wis1 Modulates the Fission Yeast Mitogen-Activated Protein Kinase Response to H2O2 and Is the Target of a Small Molecule
  17. Lighting Up DNA with the Environment‐Sensitive Bright Adenine Analogue qAN4
  18. Interbase FRET in RNA: from A to Z
  19. A Fluorescent Kinase Inhibitor that Exhibits Diagnostic Changes in Emission upon Binding
  20. A Fluorescent Kinase Inhibitor that Exhibits Diagnostic Changes in Emission upon Binding
  21. Shining New Light on the Spiropyran Photoswitch: A Photocage Decides between cis–trans or Spiro-Merocyanine Isomerization
  22. Synthesis, oligonucleotide incorporation and fluorescence properties in DNA of a bicyclic thymine analogue
  23. Synthesis and Photophysical Characterization of Azoheteroarenes
  24. Drug Repositioning for Effective Prostate Cancer Treatment
  25. Plasmodium dihydrofolate reductase is a second enzyme target for the antimalarial action of triclosan
  26. Fluorescent nucleobase analogues for base–base FRET in nucleic acids: synthesis, photophysics and applications
  27. Pentacyclic adenine: a versatile and exceptionally bright fluorescent DNA base analogue
  28. Pulse-shaped two-photon excitation of a fluorescent base analogue approaches single-molecule sensitivity
  29. Improving the economics of NASH/NAFLD treatment through the use of systems biology
  30. Network analyses identify liver‐specific targets for treating liver diseases
  31. Toward Complete Sequence Flexibility of Nucleic Acid Base Analogue FRET
  32. On the use of diarylmaleimide derivatives in biological contexts: An investigation of the photochromic properties in aqueous solution
  33. Structural Insights into the Polyphyletic Origins of Glycyl tRNA Synthetases
  34. Chroman-4-one and chromone based somatostatin β-turn mimetics
  35. 7-(Benzofuran-2-yl)-7-deazadeoxyguanosine as a fluorescence turn-ON probe for single-strand DNA binding protein
  36. An acido- and photochromic molecular device that mimics triode action
  37. Defects in the calcium-binding region drastically affect the cadherin-like domains of RET tyrosine kinase
  38. Flexibility is important for inhibition of the MDM2/p53 protein–protein interaction by cyclic β-hairpins
  39. Arsenic Directly Binds to and Activates the Yeast AP-1-Like Transcription Factor Yap8
  40. Design, Synthesis and Evaluation of 2,5-Diketopiperazines as Inhibitors of the MDM2-p53 Interaction
  41. A Caged Ret Kinase Inhibitor and its Effect on Motoneuron Development in Zebrafish Embryos
  42. Development of bright fluorescent quadracyclic adenine analogues: TDDFT-calculation supported rational design
  43. Characterization of interactions and pharmacophore development for DFG-out inhibitors to RET tyrosine kinase
  44. Design, Synthesis and Inhibitory Activity of Photoswitchable RET Kinase Inhibitors
  45. 8-Triazolylpurines: Towards Fluorescent Inhibitors of the MDM2/p53 Interaction
  46. The unique characteristics of HOG pathway MAPKs in the extremely halotolerant Hortaea werneckii
  47. Second‐Generation Fluorescent Quadracyclic Adenine Analogues: Environment‐Responsive Probes with Enhanced Brightness
  48. HwHog1 kinase activity is crucial for survival of Hortaea werneckii in extremely hyperosmolar environments
  49. Selective inhibition of RET mediated cell proliferation in vitro by the kinase inhibitor SPP86
  50. Towards the development of chromone-based MEK1/2 modulators
  51. 8-Bromination of 2,6,9-trisubstituted purines with pyridinium tribromide
  52. Application of a peptide-based assay to characterize inhibitors targeting protein kinases from yeast
  53. A Single-Cell Study of a Highly Effective Hog1 Inhibitor for in Situ Yeast Cell Manipulation
  54. Synthesis and photophysical characterisation of new fluorescent triazole adenine analogues
  55. Inhibition of MAPK Hog1 Results in Increased Hsp104 Aggregate Formation Probably through Elevated Arsenite Influx into the Cells, an Approach with Numerous Potential Applications
  56. Chromo-pharmacophores: photochromic diarylmaleimide inhibitors for sirtuins
  57. Synthesis and photophysical characterization of 1- and 4-(purinyl)triazoles
  58. Effect of MAPK Inhibitor on the Arsenite uptake by Aquaglyceroporin in Single Yeast Cells
  59. Design and evaluation of a microfluidic system for inhibition studies of yeast cell signaling
  60. Validation of regulated protein phosphorylation events in yeast by quantitative mass spectrometry analysis of purified proteins
  61. Proline-mediated formation of novel chroman-4-one tetrahydropyrimidines
  62. Determination of primary sequence specificity of Arabidopsis MAPKs MPK3 and MPK6 leads to identification of new substrates
  63. Method for Activation and Recycling of Trityl Resins
  64. Solid‐Phase Synthesis of 5′‐O‐[N‐(Acyl)sulfamoyl]adenosine Derivatives
  65. Preparation of 3-Substituted-1-Isopropyl-1H-pyrazolo[3,4-d]pyrimidin-4-amines as RET Kinase Inhibitors
  66. Investigation, optimization and synthesis of sulfamoyloxy-linked aminoacyl-AMP analogues
  67. Design, Synthesis, and Biological Evaluation of Chromone-Based p38 MAP Kinase Inhibitors
  68. NMR-Based Substrate Analog Docking to Escherichia coli Peptidyl-tRNA Hydrolase
  69. Design, Synthesis and Characterization of a Highly Effective Inhibitor for Analog-Sensitive (as) Kinases
  70. Design, Synthesis, and Characterization of a Highly Effective Hog1 Inhibitor: A Powerful Tool for Analyzing MAP Kinase Signaling in Yeast
  71. Inhibitors and promoters of tubulin polymerization: Synthesis and biological evaluation of chalcones and related dienones as potential anticancer agents
  72. Characterization of photophysical and base-mimicking properties of a novel fluorescent adenine analogue in DNA
  73. Positional Scanning Peptide Libraries for Kinase Substrate Specificity Determinations: Straightforward and Reproducible Synthesis Using Pentafluorophenyl Esters
  74. KHMDS Enhanced SmI2-Mediated Reformatsky Type α-Cyanation
  75. Structural Influence on Radical Formation and Sensitizing Capacity of Alkylic Limonene Hydroperoxide Analogues in Allergic Contact Dermatitis
  76. Synthesis of Chiral 1,4-Disubstituted-1,2,3-Triazole Derivatives from Amino Acids
  77. Solid-Phase Peptide Synthesis in Water Using Microwave-Assisted Heating
  78. 2,6,8‐Trisubstituted 3‐Hydroxychromone Derivatives as Fluorophores for Live‐Cell Imaging
  79. Synthesis and Photophysical Characterisation of Fluorescent 8‐(1H‐1,2,3‐Triazol‐4‐yl)adenosine Derivatives
  80. Synthesis of 2-Alkyl-Substituted Chromone Derivatives Using Microwave Irradiation
  81. Synthesis of 3-(1,2,3-triazol-1-yl)- and 3-(1,2,3-triazol-4-yl)-substituted pyrazolo[3,4-d]pyrimidin-4-amines via click chemistry: potential inhibitors of the Plasmodium falciparum PfPK7 protein kinase
  82. Short cut to 1,2,3-triazole-based p38 MAP kinase inhibitorsvia [3+2]-cycloaddition chemistry
  83. Enhanced microwave‐assisted method for on‐bead disulfide bond formation: Synthesis of α‐conotoxin MII
  84. Carbon- and Oxygen-Centered Radicals Are Equally Important Haptens of Allylic Hydroperoxides in Allergic Contact Dermatitis
  85. Synthesis and photophysical properties of novel cyclonucleosides—substituent effects on fluorescence emission
  86. Synthesis of 2′-([1,2,3]Triazol-1-yl)-2′-deoxyadenosines
  87. Microwave assisted synthesis of spiro-2,5-diketopiperazines
  88. A practical synthesis of 2′-aminoacylamino-2′-deoxyadenosines
  89. Synthesis of 3-Aminomethyl-2-aryl- 8-bromo-6-chlorochromones
  90. Synthesis of Functionalized, Unsymmetrical 1,3,4,6-Tetrasubstituted 2,5-Diketopiperazines
  91. Microwave-Assisted Solid-Phase Synthesis of 2,5-Diketopiperazines:  Solvent and Resin Dependence
  92. Synthesis of 2,3,6,8-Tetrasubstituted Chromone Scaffolds
  93. Efficient synthesis of 2,5-diketopiperazines using microwave assisted heating
  94. Microwave-assisted synthesis of the Schöllkopf chiral auxiliaries: (3S)- and (3R)-3,6-dihydro-2,5-diethoxy-3-isopropyl-pyrazine
  95. ROLE OF THE SUBUNIT COMPOSITION OF CENTRAL NICOTINIC ACETYLCHOLINE RECEPTORS FOR THE STIMULATORY AND DOPAMINE-ENHANCING EFFECTS OF ETHANOL
  96. A Scaffold Approach to 3,6,8-Trisubstituted Flavones
  97. Discovering New Classes of Brugia malayi Asparaginyl-tRNA Synthetase Inhibitors and Relating Specificity to Conformational Change
  98. Synthesis of adenosine-based fluorosides containing a novel heterocyclic ring system
  99. The Biotin Repressor: Modulation of Allostery by Corepressor Analogs
  100. Structural and Mechanistic Basis of Pre- and Posttransfer Editing by Leucyl-tRNA Synthetase
  101. ChemInform Abstract: Physical Properties of Polyethylene Glycol (PEG)‐Based Resins for Solid‐Phase Organic Chemistry: A Comparison of PEG Crosslinked and PEG Grafted Resins.
  102. SPOCC-194, a New High Functional Group Density PEG-Based Resin for Solid-Phase Organic Synthesis
  103. Palladium on Carbon Encapsulated in POEPOP1500:  A Resin-Supported Catalyst for Hydrogenation Reactions
  104. Solid-Phase Glycosylation of Peptide Templates and On-Bead MAS-NMR Analysis: Perspectives for Glycopeptide Libraries
  105. Diffusion of Reagents in Macrobeads
  106. A succession of substrate induced conformational changes ensures the amino acid specificity of Thermus thermophilus prolyl-tRNA synthetase: comparison with histidyl-tRNA synthetase
  107. ChemInform Abstract: Identification of Protease Inhibitors Using Biocompatible Resins and Library Synthesis
  108. Surfactant Mediated Cationic and Anionic Suspension Polymerization of PEG-Based Resins in Silicon Oil:  Beaded SPOCC 1500 and POEPOP 1500
  109. Crystallization and preliminary crystallographic analysis ofThermus thermophilusleucyl-tRNA synthetase and its complexes with leucine and a non-hydrolysable leucyl-adenylate analogue
  110. Physical Properties of Poly(ethylene glycol) (PEG)-Based Resins for Combinatorial Solid Phase Organic Chemistry:  A Comparison of PEG-Cross-Linked and PEG-Grafted Resins
  111. Towards peptide isostere libraries: aqueous aldol reactions on hydrophilic solid supports
  112. HYDRA: A novel hydroxy and amine functionalised resin synthesised by reductive amination of PEG aldehyde and a polyamine
  113. Single-bead structure elucidation. Requirements for analysis of combinatorial solid-phase libraries by Nanoprobe MAS-NMR spectroscopy
  114. SPOCC:  A Resin for Solid-Phase Organic Chemistry and Enzymatic Reactions on Solid Phase
  115. 2′-O-(carbamoylmethyl)oligoribonucleotides
  116. Identification of Protease Inhibitors Using Biocompatible Resins and Library Synthesis
  117. The crystal structure of asparaginyl-tRNA synthetase from Thermus thermophilus and its complexes with ATP and asparaginyl-adenylate: the mechanism of discrimination between asparagine and aspartic acid
  118. 2′-O-Propargyl oligoribonucleotides: Synthesis and hybridisation
  119. Solid-phase synthesis of branched RNA and branched DNA/RNA chimeras
  120. A simple method for the synthesis of 2′-O-alkylguanosine derivatives
  121. Protection of the guanine residue during synthesis of 2′-O-alkylguanosine derivatives
  122. Ether, Carbonate and Urethane Deoxynucleoside Derivatives as Prodrugs.
  123. Lithofibrin. A New Remarkably Stable Substance Found in Renal Stones.
  124. Synthesis of 2'-Allyl-2'-Deoxyribonucleosides by Radical Reactions.
  125. Design and Synthesis of Novel Chromone Based Peptidomimetics
  126. SPOCC resins: Polar and chemically inert resins for organic synthesis and library enzyme assays
  127. Investigation of enzyme activity and inhibition in the interior of novel solid supports