Contact

All Stories

  1. N-Nitrosation in the absence of nitrosating agents in pharmaceuticals?

    Article • Journal of Pharmaceutical and Biomedical Analysis, September 2022, Elsevier

    Michal Douša

  2. Nitrites as precursors of N-nitrosation in pharmaceutical samples – A trace level analysis

    Article • Journal of Pharmaceutical and Biomedical Analysis, May 2022, Elsevier

    Michal Douša

  3. The determination of two analogues of 4-(azidomethyl)-1,1'-biphenyl as potential genotoxic impurities in the active pharmaceutical ingredient of several sartans containing a tetrazole group

    Article • Journal of Pharmaceutical and Biomedical Analysis, October 2021, Elsevier

    Michal Douša

  4. Analytical quality by design in the development of a solvent-modified micellar electrokinetic chromatography method for the determination of sitagliptin and its related compounds

    Article • Journal of Pharmaceutical and Biomedical Analysis, August 2021, Elsevier

    Michal Douša

  5. Separation of pharmaceutically active compounds by multimodal chromatography with ultraviolet detection

    Article • Separation Science Plus, June 2021, Wiley

    Michal Douša

  6. Insight into the formation of N-nitrosodimethylamine in metformin products

    Article • Journal of Pharmaceutical and Biomedical Analysis, February 2021, Elsevier

    Michal Douša

  7. HILIC-MS determination of dimethylamine in the active pharmaceutical ingredients and in the dosage forms of metformin

    Article • Journal of Pharmaceutical and Biomedical Analysis, November 2020, Elsevier

    Michal Douša

  8. Development of HPLC Method for the Purity Test by Design of Experiments and Determination of Activation Energy of Hydrolytic Degradation Reactions of Sofosbuvir

    Article • Current Pharmaceutical Analysis, August 2020, Bentham Science Publishers

    Jakub Hert, Filip Vymyslicky, Michal Douša

  9. Detection and structure elucidation of the new degradation impurities in the pharmaceutical formulations of ruxolitinib hydrobromide

    Article • Journal of Pharmaceutical and Biomedical Analysis, July 2020, Elsevier

    Michal Douša

  10. Supercritical fluid chromatography in chiral separations: Evaluation of equivalency of polysaccharide stationary phases

    Article • Journal of Separation Science, June 2020, Wiley

    Michal Douša

  11. Quality by Design as a risk-based strategy in pharmaceutical analysis: Development of a liquid chromatography-tandem mass spectrometry method for the determination of nintedanib and its impurities

    Article • Journal of Chromatography A, January 2020, Elsevier

    Michal Douša, Dott Giuseppe Pieraccini

  12. Enantioseparation of N-acetyl-dl-cysteine as o-phtaldialdehyde derivatives obtained with various primary aliphatic amine additives on polysaccharide-based chiral stationary phases

    Article • Journal of Pharmaceutical and Biomedical Analysis, March 2019, Elsevier

    Michal Douša

  13. Chiral separation of aliphatic primary amino alcohols as o -phthaldialdehyde/mercaptoethanol derivatives on polysaccharide-based chiral stationary phases

    Article • Chirality, January 2019, Wiley

    Michal Douša

  14. HPLC/UV/MS method application for the separation of obeticholic acid and its related compounds in development process and quality control

    Article • Journal of Pharmaceutical and Biomedical Analysis, February 2018, Elsevier

    Michal Douša

  15. 1H-Tetrazole-5-amine Immobilized on Substituted Polymer Gel/Silica as a New Stationary Phase for Hydrophilic Interaction Chromatography

    Article • Chromatographia, December 2017, Springer Science + Business Media

    Michal Douša

  16. Separation of structurally related primary aliphatic amines using hydrophilic interaction chromatography with fluorescence detection after postcolumn derivatization with o -phthaldialdehyde/mercaptoethanol

    Article • Journal of Separation Science, December 2017, Wiley

    Michal Douša

  17. Esterification of Ibuprofen in Soft Gelatin Capsules Formulations—Identification, Synthesis and Liquid Chromatography Separation of the Degradation Products

    Article • Journal of Chromatographic Science, May 2017, Oxford University Press (OUP)

    Michal Douša

  18. Enantiomeric Separation of (R,S)-Aclidinium Bromide with Negatively Charged Gamma-Cyclodextrin by CE

    Article • Chromatographia, January 2017, Springer Science + Business Media

    Michal Douša

  19. General screening and optimization strategy for fast chiral separations in modern supercritical fluid chromatography

    Article • Analytica Chimica Acta, January 2017, Elsevier

    Michal Douša

  20. A novel approach for HPLC determination of 2-cynaoacetamide using derivatization procedure with 2-hydroxyacetophenone as a new useful derivatization reagent

    Article • Journal of Pharmaceutical and Biomedical Analysis, September 2016, Elsevier

    Michal Douša

  21. Optimization ofo-phtaldialdehyde/2-mercaptoethanol postcolumn reaction for the hydrophilic interaction liquid chromatography determination of memantine utilizing a silica hydride stationary phase

    Article • Journal of Separation Science, August 2016, Wiley

    Michal Douša

  22. Quality by Design-Guided Development of a Capillary Electrophoresis Method for the Chiral Purity Determination of Ambrisentan

    Article • Chromatographia, July 2016, Springer Science + Business Media

    Michal Douša

  23. Utilization of Photochemically Induced Fluorescence Detection for HPLC Determination of Genotoxic Impurities in the Vortioxetine Manufacturing Process

    Article • Journal of Chromatographic Science, July 2016, Oxford University Press (OUP)

    Michal Douša

  24. Development, validation and comparison of UHPSFC and UHPLC methods for the determination of agomelatine and its impurities

    Article • Journal of Pharmaceutical and Biomedical Analysis, June 2016, Elsevier

    Michal Douša

  25. Effect of Chromatographic Conditions on Enantioseparation of Bedaquiline Using Polysaccharide-based Chiral Stationary Phases in RP-HPLC

    Article • Journal of Chromatographic Science, April 2016, Oxford University Press (OUP)

    Michal Douša

  26. Quantification of structurally related aliphatic amino alcohols inl-valinol by hydrophilic interaction liquid chromatography separation combined with postcolumn derivatization and fluorescence detection

    Article • Journal of Separation Science, January 2016, Wiley

    Michal Douša

  27. Enantiomeric purity control of R-cinacalcet in pharmaceutical product by capillary electrophoresis

    Article • Chemical Papers, January 2016, Springer Science + Business Media

    Michal Douša

  28. New approach of validation using internal normalization technique for quantification of related substances in raw material, intermediates and pharmaceutical substances by HPLC

    Article • Journal of Pharmaceutical and Biomedical Analysis, October 2015, Elsevier

    Michal Douša

  29. HILIC–MS Determination of Genotoxic Impurity of 2-Chloro-N-(2-Chloroethyl)Ethanamine in the Vortioxetine Manufacturing Process

    Article • Journal of Chromatographic Science, July 2015, Oxford University Press (OUP)

    Michal Douša

  30. Enantiomeric separation of tapentadol by capillary electrophoresis—Study of chiral selectivity manipulation by various types of cyclodextrins

    Article • Journal of Pharmaceutical and Biomedical Analysis, February 2015, Elsevier

    Michal Douša

  31. Direct analysis in real time – High resolution mass spectrometry as a valuable tool for the pharmaceutical drug development

    Article • Talanta, December 2014, Elsevier

    Michal Douša

  32. Identification, characterization, synthesis and HPLC quantification of new process-related impurities and degradation products in retigabine

    Article • Journal of Pharmaceutical and Biomedical Analysis, June 2014, Elsevier

    Michal Douša

  33. Retention behavior of a homologous series and positional isomers of aliphatic amino acids in hydrophilic interaction chromatography

    Article • Journal of Separation Science, March 2014, Wiley

    Michal Douša

  34. Underivatized amylose and cellulose as new stationary phases for hydrophilic interaction chromatography

    Article • Journal of Separation Science, September 2013, Wiley

    Michal Douša

  35. Enantiomeric separation ofR,S-tolterodine andR,S-methoxytolterodine with negatively charged cyclodextrins by capillary electrophoresis

    Article • Journal of Separation Science, May 2013, Wiley

    Michal Douša

  36. Fundamental study of enantioselective HPLC separation of tapentadol enantiomers using cellulose-based chiral stationary phase in normal phase mode

    Article • Journal of Pharmaceutical and Biomedical Analysis, February 2013, Elsevier

    Michal Douša

  37. Chiral Chromatography Studies of Chemical Behavior of Cinacalcet on Polysaccharide Chiral Reversed-Phase HPLC Stationary Phases

    Article • Journal of AOAC International, November 2012, The Journal of AOAC International

    Michal Douša

  38. Rapid HILIC method with fluorescence detection using derivatization reaction utilizing o-phthaldialdehyde for determination of degradation product of aliskiren

    Article • Journal of Pharmaceutical and Biomedical Analysis, July 2012, Elsevier

    Michal Douša

  39. The Formation of Furfural Compounds in Selected Saccharide- and Polysaccharide-based Pharmaceutical Excipients

    Article • Journal of Pharmaceutical Sciences, May 2012, Elsevier

    Michal Douša

  40. Rapid determination of ambrisentan enantiomers by enantioselective liquid chromatography using cellulose-based chiral stationary phase in reverse phase mode

    Article • Journal of Separation Science, April 2012, Wiley

    Michal Douša

  41. Rapid determination of ambrisentan enantiomers by enantioselective liquid chromatography using cellulose-based chiral stationary phase in reverse phase mode

    Article • Journal of Separation Science, March 2012, Wiley

    Michal Douša

  42. Identification, preparation and UHPLC determination of process-related impurity in zolmitriptan

    Article • Journal of Pharmaceutical and Biomedical Analysis, January 2012, Elsevier

    Michal Douša

  43. Drug-excipient compatibility testing—Identification and characterization of degradation products of phenylephrine in several pharmaceutical formulations against the common cold

    Article • Journal of Pharmaceutical and Biomedical Analysis, July 2011, Elsevier

    Michal Douša

  44. Liquid chromatographic method for enantiopurity control of alaptide using polysaccharide stationary phases

    Article • Journal of Separation Science, May 2011, Wiley

    Michal Douša

  45. Rapid hydrophilic interaction chromatography determination of lysine in pharmaceutical preparations with fluorescence detection after postcolumn derivatization with o-phtaldialdehyde

    Article • Journal of Pharmaceutical and Biomedical Analysis, April 2011, Elsevier

    Michal Douša

  46. Liquid chromatographic separation of pregabalin and its possible impurities with fluorescence detection after postcolumn derivatization with o-phtaldialdehyde

    Article • Journal of Pharmaceutical and Biomedical Analysis, November 2010, Elsevier

    Michal Douša

  47. HPLC determination of lincomycin in premixes and feedstuffs with solid-phase extraction on HLB OASIS and LC–MS/MS confirmation

    Article • Journal of Pharmaceutical and Biomedical Analysis, March 2006, Elsevier

    Michal Douša

  48. Rapid determination of amoxicillin in premixes by HPLC

    Article • Journal of Pharmaceutical and Biomedical Analysis, February 2005, Elsevier

    Michal Douša