All Stories

  1. A review article describing why chylomicrons and VLDL are harmful

    Article • Current Medicinal Chemistry, May 2019, Bentham Science Publishers

    Dr Katariina Öörni, Petri Kovanen

  2. The quality of LDL is a new risk factor in cardiovascular diseases

    Article • European Heart Journal, July 2018, Oxford University Press (OUP)

    Dr Katariina Öörni

  3. Human mast cell neutral proteases generate modified LDL particles with increased proteoglycan binding

    Article • Atherosclerosis, April 2018, Elsevier

    Dr Katariina Öörni, Mikko I. Mäyränpää

  4. Lipoproteins accumulate in arteries, become modified and cause inflammation

    Article • American Journal Of Pathology, February 2018, Elsevier

    Dr Katariina Öörni, Dr Satu Lehti

  5. PCSK9 inhibition alters the lipidome of plasma and lipoprotein fractions

    Article • Atherosclerosis, February 2018, Elsevier

    Dr Katariina Öörni

  6. Thermodynamic and kinetic approaches for evaluation of monoclonal antibody - Lipoprotein interactions

    Article • Analytical Biochemistry, February 2017, Elsevier

    Dr Katariina Öörni, M.Sc. and M.Sc.(Tech.) Evgen Multia

  7. Tailor-made approach for selective isolation and elution of low-density lipoproteins by immunoaffinity sorbent on silica

    Article • Analytical Biochemistry, December 2016, Elsevier

    Dr Katariina Öörni, M.Sc. and M.Sc.(Tech.) Evgen Multia

  8. p38δ MAPKHighlights

    Article • Arteriosclerosis Thrombosis and Vascular Biology, July 2016, Wolters Kluwer Health

    Dr Katariina Öörni, Mikko I. Mäyränpää

  9. Carboxyl-Terminal Cleavage of Apolipoprotein A-I by Human Mast Cell Chymase Impairs Its Anti-Inflammatory PropertiesSignificance

    Article • Arteriosclerosis Thrombosis and Vascular Biology, December 2015, Wolters Kluwer Health

    Dr Katariina Öörni

  10. Electronegative LDL induces priming and inflammasome activation leading to IL-1β release in human monocytes and macrophages

    Article • Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, November 2015, Elsevier

    Dr Katariina Öörni

  11. Lipoprotein-associated lipids accumulate in distinctive domains in atherosclerotic arteries.

    Article • American Journal Of Pathology, May 2015, Elsevier

    Dr Katariina Öörni, Dr Satu Lehti, Mikko I. Mäyränpää

  12. Apolipoprotein A-I mimetic peptide 4F blocks sphingomyelinase-induced LDL aggregation

    Article • Journal of Lipid Research, April 2015, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Seppo Yla-Herttuala, Dr Katariina Öörni

  13. Atherosclerotic lesions are acidic - here's an explanation why

    Article • Journal of Lipid Research, November 2014, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Katariina Öörni

  14. Cathepsin G activity lowers plasma LDL and reduces atherosclerosis

    Article • Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, November 2014, Elsevier

    Dr Katariina Öörni

  15. Activated Human Mast Cells Induce LOX-1-Specific Scavenger Receptor Expression in Human Monocyte-Derived Macrophages

    Article • PLoS ONE, September 2014, PLOS

    Dr Katariina Öörni

  16. Potential pathological roles for oxidized low-density lipoprotein and scavenger receptors SR-AI, CD36, and LOX-1 in aortic valve stenosis

    Article • Atherosclerosis, August 2014, Elsevier

    Dr Katariina Öörni

  17. Three complementary techniques for the clarification of temperature effect on low-density lipoprotein–chondroitin-6-sulfate interaction

    Article • Analytical Biochemistry, December 2013, Elsevier

    Dr Katariina Öörni

  18. Modified Lipoprotein-Derived Lipid Particles Accumulate in Human Stenotic Aortic Valves

    Article • PLoS ONE, June 2013, PLOS

    Dr Katariina Öörni, Dr Satu Lehti

  19. Angptl3 Deficiency Is Associated With Increased Insulin Sensitivity, Lipoprotein Lipase Activity, and Decreased Serum Free Fatty Acids

    Article • Arteriosclerosis Thrombosis and Vascular Biology, May 2013, Wolters Kluwer Health

    Dr Katariina Öörni

  20. Extracellular Acidosis Is a Novel Danger Signal Alerting Innate Immunity via the NLRP3 Inflammasome

    Article • Journal of Biological Chemistry, March 2013, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Katariina Öörni

  21. Plasma low-density lipoprotein immobilized silica as stationary phase in nano-liquid chromatography

    Article • Journal of Chromatography A, December 2012, Elsevier

    Dr Katariina Öörni

  22. Spontaneous remodeling of HDL particles at acidic pH enhances their capacity to induce cholesterol efflux from human macrophage foam cells

    Article • Journal of Lipid Research, August 2012, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Katariina Öörni

  23. Conformational changes of apoB-100 in SMase-modified LDL mediate formation of large aggregates at acidic pH

    Article • Journal of Lipid Research, June 2012, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Katariina Öörni

  24. Capillary electrochromatography and quartz crystal microbalance, valuable techniques in the study of heparin–lipoprotein interactions

    Article • Analytical Biochemistry, May 2012, Elsevier

    Dr Katariina Öörni

  25. Acidity and lipolysis by group V secreted phospholipase A2 strongly increase the binding of apoB-100-containing lipoproteins to human aortic proteoglycans

    Article • Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, February 2012, Elsevier

    Dr Katariina Öörni

  26. Acidity increases the uptake of native LDL by human monocyte-derived macrophages

    Article • Atherosclerosis, August 2011, Elsevier

    Dr Katariina Öörni

  27. Three-Dimensional cryoEM Reconstruction of Native LDL Particles to 16Å Resolution at Physiological Body Temperature

    Article • PLoS ONE, May 2011, PLOS

    Dr Sarah Jane Butcher, Dr Katariina Öörni

  28. Serum Amyloid A Activates the NLRP3 Inflammasome via P2X7 Receptor and a Cathepsin B-Sensitive Pathway

    Article • The Journal of Immunology, April 2011, The American Association of Immunologists

    Dr Katariina Öörni

  29. Immunochemical Analysis of the Electronegative LDL Subfraction Shows That Abnormal N-terminal Apolipoprotein B Conformation Is Involved in Increased Binding to Proteoglycans

    Article • Journal of Biological Chemistry, November 2010, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Katariina Öörni

  30. Cholesterol Crystals Activate the NLRP3 Inflammasome in Human Macrophages: A Novel Link between Cholesterol Metabolism and Inflammation

    Article • PLoS ONE, July 2010, PLOS

    Dr Katariina Öörni

  31. Sugar treatment of human lipoprotein particles and their separation by capillary electrophoresis

    Article • Journal of Separation Science, July 2010, Wiley

    Dr Katariina Öörni

  32. Open tubular capillary electrochromatography: A useful microreactor for collagen I glycation and interaction studies with low-density lipoprotein particles

    Article • Analytica Chimica Acta, April 2010, Elsevier

    Dr Katariina Öörni

  33. Partial filling affinity capillary electrophoresis with cationic poly(vinylpyrrolidone)-based copolymer coatings for studies on human lipoprotein–steroid interactions

    Article • Analytical Biochemistry, April 2010, Elsevier

    Dr Katariina Öörni

  34. Proteolysis sensitizes LDL particles to phospholipolysis by secretory phospholipase A2group V and secretory sphingomyelinase

    Article • Journal of Lipid Research, February 2010, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Katariina Öörni

  35. Phospholipase A2-modified LDL particles retain the generated hydrolytic products and are more atherogenic at acidic pH

    Article • Atherosclerosis, December 2009, Elsevier

    Dr Katariina Öörni

  36. CEC: A tool for mimicking collagen–surface interactions with apolipoprotein B-100 peptides

    Article • Electrophoresis, November 2009, Wiley

    Dr Katariina Öörni

  37. Lipoprotein modification by secretory phospholipase A2 enzymes contributes to the initiation and progression of atherosclerosis

    Article • Current Opinion in Lipidology, October 2009, Wolters Kluwer Health

    Dr Katariina Öörni

  38. High negative charge-to-size ratio in polyphosphates and heparin regulates factor VII-activating protease

    Article • FEBS Journal, July 2009, Wiley

    Dr Katariina Öörni

  39. In situ delipidation of low-density lipoproteins in capillary electrochromatography yields apolipoprotein B-100-coated surfaces for interaction studies

    Article • Analytical Biochemistry, December 2008, Elsevier

    Dr Katariina Öörni

  40. High binding affinity of electronegative LDL to human aortic proteoglycans depends on its aggregation level

    Article • Journal of Lipid Research, October 2008, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Katariina Öörni

  41. Proteolysis of low density lipoprotein particles by Porphyromonas gingivalis microorganisms: a novel biochemical link between periodontitis and cardiovascular diseases?

    Article • Journal of Internal Medicine, May 2008, Wiley

    Dr Katariina Öörni

  42. 1H NMR at 800MHz facilitates detailed phospholipid follow-up during atherogenic modifications in low density lipoproteins

    Article • Biochemical and Biophysical Research Communications, August 2007, Elsevier

    Dr Katariina Öörni

  43. Angiotensin II increases expression and secretion of cathepsin F in cultured human monocyte-derived macrophages: An angiotensin II type 2 receptor-mediated effect

    Article • Atherosclerosis, June 2007, Elsevier

    Dr Katariina Öörni

  44. Open tubular CE forin vitro oxidation studies of human very-low-density lipoprotein particles

    Article • Electrophoresis, March 2007, Wiley

    Dr Katariina Öörni

  45. PLA2-V: A Real Player in Atherogenesis

    Article • Arteriosclerosis Thrombosis and Vascular Biology, March 2007, Wolters Kluwer Health

    Dr Katariina Öörni

  46. Open tubular capillary electrochromatography: a new technique for in situ enzymatic modification of low density lipoprotein particles and their protein-free derivatives

    Article • The Analyst, January 2007, Royal Society of Chemistry

    Dr Katariina Öörni

  47. Enhanced extracellular lipid accumulation in acidic environments

    Article • Current Opinion in Lipidology, October 2006, Wolters Kluwer Health

    Dr Katariina Öörni

  48. Increased Expression of Elastolytic Cathepsins S, K, and V and Their Inhibitor Cystatin C in Stenotic Aortic Valves

    Article • Arteriosclerosis Thrombosis and Vascular Biology, August 2006, Wolters Kluwer Health

    Dr Katariina Öörni, Mikko I. Mäyränpää

  49. Miniaturization of asymmetrical flow field-flow fractionation and application to studies on lipoprotein aggregation and fusion

    Article • Analytical Biochemistry, July 2006, Elsevier

    Susanne Kristina Wiedmer, Dr Katariina Öörni

  50. Open Tubular Capillary Electrochromatography:  Technique for Oxidation and Interaction Studies on Human Low-Density Lipoproteins

    Article • Analytical Chemistry, April 2006, American Chemical Society (ACS)

    Dr Katariina Öörni

  51. Decrease in pH Strongly Enhances Binding of Native, Proteolyzed, Lipolyzed, and Oxidized Low Density Lipoprotein Particles to Human Aortic Proteoglycans

    Article • Journal of Biological Chemistry, September 2005, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Katariina Öörni

  52. Sphingomyelinase Induces Aggregation and Fusion of Small Very Low-Density Lipoprotein and Intermediate-Density Lipoprotein Particles and Increases Their Retention to Human Arterial Proteoglycans

    Article • Arteriosclerosis Thrombosis and Vascular Biology, May 2005, Wolters Kluwer Health

    Dr Katariina Öörni

  53. Human Low-Density Lipoprotein-Coated Capillaries in Electrochromatography

    Article • Analytical Chemistry, May 2005, American Chemical Society (ACS)

    Susanne Kristina Wiedmer, Dr Katariina Öörni

  54. Cysteine Protease Cathepsin F Is Expressed in Human Atherosclerotic Lesions, Is Secreted by Cultured Macrophages, and Modifies Low Density Lipoprotein Particlesin Vitro

    Article • Journal of Biological Chemistry, June 2004, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Katariina Öörni, Mikko I. Mäyränpää

  55. The mast cell, a rich source of neutral proteases in atherosclerotic plaques

    Article • International Congress Series, May 2004, Elsevier

    Dr Katariina Öörni

  56. Cathepsins F and S block HDL3-induced cholesterol efflux from macrophage foam cells

    Article • Biochemical and Biophysical Research Communications, December 2003, Elsevier

    Dr Katariina Öörni

  57. Lipoprotein Lipase in the Arterial Wall: Linking LDL to the Arterial Extracellular Matrix and Much More

    Article • Arteriosclerosis Thrombosis and Vascular Biology, February 2002, Wolters Kluwer Health

    Dr Katariina Öörni

  58. Myeloperoxidase and Hypochlorite, but Not Copper Ions, Oxidize Heparin-Bound LDL Particles and Release Them From Heparin

    Article • Arteriosclerosis Thrombosis and Vascular Biology, December 2001, Wolters Kluwer Health

    Dr Katariina Öörni

  59. Phospholipase A2 in Vascular Disease

    Article • Circulation Research, August 2001, Wolters Kluwer Health

    Dr Katariina Öörni

  60. Lipolysis of LDL by Human Secretory Phospholipase A2 Induces Particle Fusion and Enhances the Retention of LDL to Human Aortic Proteoglycans

    Article • Arteriosclerosis Thrombosis and Vascular Biology, June 2001, Wolters Kluwer Health

    Dr Katariina Öörni

  61. Changes in a Phospholipid Bilayer Induced by the Hydrolysis of a Phospholipase A2 Enzyme: A Molecular Dynamics Simulation Study

    Article • Biophysical Journal, February 2001, Elsevier

    Dr Katariina Öörni

  62. Modified LDL - trigger of atherosclerosis and inflammation in the arterial intima

    Article • Journal of Internal Medicine, March 2000, Wiley

    Dr Katariina Öörni

  63. Lipoprotein Lipase (LPL) Strongly Links Native and Oxidized Low Density Lipoprotein Particles to Decorin-coated Collagen

    Article • Journal of Biological Chemistry, February 2000, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Katariina Öörni

  64. Mast Cells in Atherogenesis: A Model for Studying Proteolytic Modification of Low and High Density Lipoproteins

    Article • January 2000, Springer Science + Business Media

    Dr Katariina Öörni

  65. Lipolytic Modification of LDL by Phospholipase A2 Induces Particle Aggregation in the Absence and Fusion in the Presence of Heparin

    Article • Arteriosclerosis Thrombosis and Vascular Biology, May 1999, Wolters Kluwer Health

    Dr Katariina Öörni

  66. Sphingomyelinase Induces Aggregation and Fusion, but Phospholipase A2Only Aggregation, of Low Density Lipoprotein (LDL) Particles

    Article • Journal of Biological Chemistry, October 1998, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Katariina Öörni

  67. Human Arterial Proteoglycans Increase the Rate of Proteolytic Fusion of Low Density Lipoprotein Particles

    Article • Journal of Biological Chemistry, October 1997, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Katariina Öörni

  68. Oxidation of Low Density Lipoprotein Particles Decreases Their Ability to Bind to Human Aortic Proteoglycans

    Article • Journal of Biological Chemistry, August 1997, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Katariina Öörni

  69. The Proteoglycan Decorin Links Low Density Lipoproteins with Collagen Type I

    Article • Journal of Biological Chemistry, March 1997, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Katariina Öörni

  70. Proteolysis and Fusion of Low Density Lipoprotein Particles Strengthen Their Binding to Human Aortic Proteoglycans

    Article • Journal of Biological Chemistry, May 1995, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Katariina Öörni

  71. Characterization of antigenic epitopes of potato virus Y

    Article • Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, March 1993, Elsevier

    Dr Katariina Öörni