All Stories

  1. Investigating a new C2-symmetric testosterone dimer and its dihydrotestosterone analog: Synthesis, antiproliferative activity on prostate cancer cell lines and interaction with CYP3A4

    Article • European Journal of Medicinal Chemistry, March 2023, Elsevier

    Professor Gervais Bérubé

  2. Synthesis of new para-aminobenzoic acid derivatives, in vitro biological evaluation and preclinical validation of DAB-2-28 as a therapeutic option for the treatment of bladder cancer

    Article • European Journal of Medicinal Chemistry Reports, December 2022, Elsevier

    Professor Gervais Bérubé

  3. Structural Characterization of Cis– and Trans–Pt(NH3)2Cl2 Conjugations with Chitosan Nanoparticles

    Article • Molecules, September 2022, MDPI AG

    Professor Gervais Bérubé

  4. Design of novel 4-maleimidylphenyl-hydrazide molecules displaying anti-inflammatory properties: Refining the chemical structure

    Article • European Journal of Medicinal Chemistry Reports, August 2022, Elsevier

    Professor Gervais Bérubé

  5. Innovative C-symmetric testosterone and androstenedione dimers: Design, synthesis, biological evaluation on prostate cancer cell lines and binding study to recombinant CYP3A4

    Article • European Journal of Medicinal Chemistry, August 2021, Elsevier

    Professor Gervais Bérubé

  6. Recent Advances in the Use of the Dimerization Strategy as a Means to Increase the Biological Potential of Natural or Synthetic Molecules

    Article • Molecules, April 2021, MDPI AG

    Professor Gervais Bérubé

  7. Locating the binding sites of two aminobenzoic acid derivatives on tRNA: drug binding efficacy and RNA structure

    Article • Journal of Biomolecular Structure and Dynamics, August 2020, Taylor & Francis

    Professor Gervais Bérubé

  8. Molecular therapy with derivatives of amino benzoic acid inhibits tumor growth and metastasis in murine models of bladder cancer through inhibition of TNFα/NFΚB and iNOS/NO pathways

    Article • Biochemical Pharmacology, June 2020, Elsevier

    Professor Gervais Bérubé

  9. Binding efficacy of aminobenzoic acid derivatives with DNA duplex: drug binding sites and DNA structure and dynamics

    Article • Journal of Biomolecular Structure and Dynamics, March 2020, Taylor & Francis

    Professor Gervais Bérubé

  10. Biomolecular study and conjugation of two para-aminobenzoic acid derivatives with serum proteins: drug binding efficacy and protein structural analysis

    Article • Journal of Biomolecular Structure and Dynamics, February 2020, Taylor & Francis

    Professor Gervais Bérubé

  11. Second-generation testosterone-platinum(II) hybrids for site-specific treatment of androgen receptor positive prostate cancer: Design, synthesis and antiproliferative activity

    Article • European Journal of Medicinal Chemistry, October 2019, Elsevier

    Professor Gervais Bérubé

  12. Complexation of cis-Pt and trans-Pt(NH3)2Cl2 with serum proteins: A potential application for drug delivery

    Article • Journal of Biomolecular Structure and Dynamics, August 2019, Taylor & Francis

    Professor Gervais Bérubé

  13. How to utilize academic research efforts in cancer drug discovery

    Article • Expert Opinion on Drug Discovery, February 2019, Taylor & Francis

    Professor Gervais Bérubé

  14. Cloning and characterization of norbelladine synthase catalyzing the first committed reaction in Amaryllidaceae alkaloid biosynthesis

    Article • BMC Plant Biology, December 2018, Springer Science + Business Media

    Professor Gervais Bérubé

  15. Testo and testo-Pt(II) bind DNA at different locations

    Article • Chemico-Biological Interactions, December 2018, Elsevier

    Professor Gervais Bérubé

  16. Location of multiple binding sites for testo and testo–Pt(II) with tRNA

    Article • Journal of Biomolecular Structure and Dynamics, November 2018, Taylor & Francis

    Professor Gervais Bérubé

  17. Conjugation of testo and testo-Pt(II) with serum proteins: Loading efficacy and protein conformation

    Article • International Journal of Biological Macromolecules, October 2018, Elsevier

    Professor Gervais Bérubé

  18. PAMAM dendrimers in drug delivery: loading efficacy and polymer morphology

    Article • Canadian Journal of Chemistry, September 2017, Canadian Science Publishing

    Professor Gervais Bérubé

  19. Effect of testosterone and its aliphatic and aromatic dimers on DNA morphology

    Article • International Journal of Biological Macromolecules, February 2017, Elsevier

    Professor Gervais Bérubé

  20. Testosterone and its dimers alter tRNA morphology

    Article • Journal of Pharmaceutical and Biomedical Analysis, February 2017, Elsevier

    Professor Gervais Bérubé

  21. Synthesis of novel C2-symmetric testosterone dimers and evaluation of antiproliferative activity on androgen-dependent and -independent prostate cancer cell lines

    Article • Steroids, November 2016, Elsevier

    Professor Gervais Bérubé

  22. Review on the delivery of steroids by carrier proteins

    Article • Journal of Photochemistry and Photobiology B Biology, August 2016, Elsevier

    Professor Gervais Bérubé

  23. An overview on the delivery of antitumor drug doxorubicin by carrier proteins

    Article • International Journal of Biological Macromolecules, July 2016, Elsevier

    Professor Gervais Bérubé

  24. Review on the binding of anticancer drug doxorubicin with DNA and tRNA: Structural models and antitumor activity

    Article • Journal of Photochemistry and Photobiology B Biology, May 2016, Elsevier

    Professor Gervais Bérubé

  25. The use of isomeric testosterone dimers to explore allosteric effects in substrate binding to cytochrome P450 CYP3A4

    Article • Journal of Inorganic Biochemistry, May 2016, Elsevier

    Professor Gervais Bérubé

  26. An overview of molecular hybrids in drug discovery

    Article • Expert Opinion on Drug Discovery, January 2016, Informa Healthcare

    Professor Gervais Bérubé

  27. Transporting testosterone and its dimers by serum proteins

    Article • Journal of Photochemistry and Photobiology B Biology, December 2015, Elsevier

    Professor Gervais Bérubé

  28. Exploring the Synthesis and Anticancer Potential of L-Tyrosine-Platinum(II) Hybrid Molecules

    Article • Medicinal Chemistry, October 2015, Bentham Science Publishers

    Professor Gervais Bérubé

  29. New Testosterone Derivatives as Semi-Synthetic Anticancer Agents Against Prostate Cancer: Synthesis and Preliminary Biological Evaluation

    Article • Medicinal Chemistry, July 2015, Bentham Science Publishers

    Professor Gervais Bérubé

  30. Encapsulation of testosterone and its aliphatic and aromatic dimers by milk beta-lactoglobulin

    Article • International Journal of Biological Macromolecules, May 2015, Elsevier

    Professor Gervais Bérubé

  31. Identification of an anti-inflammatory derivative with anti-cancer potential: The impact of each of its structural components on inflammatory responses in macrophages and bladder cancer cells

    Article • European Journal of Medicinal Chemistry, May 2015, Elsevier

    Professor Gervais Bérubé

  32. Intercalation of antitumor drug doxorubicin and its analogue by DNA duplex: Structural features and biological implications

    Article • International Journal of Biological Macromolecules, May 2014, Elsevier

    Professor Gervais Bérubé

  33. New platinum(II) complexes conjugated at position 7α of 17β-acetyl-testosterone as new combi-molecules against prostate cancer: Design, synthesis, structure–activity relationships and biological evaluation

    Article • European Journal of Medicinal Chemistry, October 2013, Elsevier

    Professor Gervais Bérubé

  34. Steroid-linked nitrogen mustards as potential anticancer therapeutics: A review

    Article • The Journal of Steroid Biochemistry and Molecular Biology, September 2013, Elsevier

    Professor Gervais Bérubé

  35. tRNA Binding to Antitumor Drug Doxorubicin and Its Analogue

    Article • PLoS ONE, July 2013, PLOS

    Professor Gervais Bérubé

  36. ERα-Targeted Therapy in Ovarian Cancer Cells by a Novel Estradiol-Platinum(II) Hybrid

    Article • Endocrinology, July 2013, Endocrine Society

    Professor Gervais Bérubé

  37. Synthesis and preliminary in vitro biological evaluation of 7α-testosterone–chlorambucil hybrid designed for the treatment of prostate cancer

    Article • European Journal of Medicinal Chemistry, June 2013, Elsevier

    Professor Gervais Bérubé

  38. Advances in the development of hybrid anticancer drugs

    Article • Expert Opinion on Drug Discovery, May 2013, Informa Healthcare

    Professor Gervais Bérubé

  39. Antibiotic doxorubicin and its derivative bind milk β-lactoglobulin

    Article • Journal of Photochemistry and Photobiology B Biology, December 2012, Elsevier

    Professor Gervais Bérubé

  40. Design, synthesis, cytocidal activity and estrogen receptor α affinity of doxorubicin conjugates at 16α-position of estrogen for site-specific treatment of estrogen receptor positive breast cancer

    Article • Steroids, September 2012, Elsevier

    Professor Gervais Bérubé

  41. Probing the Binding Sites of Antibiotic Drugs Doxorubicin and N-(trifluoroacetyl) Doxorubicin with Human and Bovine Serum Albumins

    Article • PLoS ONE, August 2012, PLOS

    Professor Gervais Bérubé

  42. Design of novel tyrosine-nitrogen mustard hybrid molecules active against uterine, ovarian and breast cancer cell lines

    Article • Steroids, April 2012, Elsevier

    Professor Gervais Bérubé

  43. Synthesis, antiproliferative activity and estrogen receptor α affinity of novel estradiol-linked platinum(II) complex analogs to carboplatin and oxaliplatin. Potential vector complexes to target estrogen-dependent tissues

    Article • European Journal of Medicinal Chemistry, February 2012, Elsevier

    Professor Gervais Bérubé

  44. SAR study of tyrosine–chlorambucil hybrid regioisomers; synthesis and biological evaluation against breast cancer cell lines

    Article • Amino Acids, November 2011, Springer Science + Business Media

    Professor Gervais Bérubé

  45. Design, synthesis and biological evaluation of estradiol-PEG-linked platinum(II) hybrid molecules: Comparative molecular modeling study of three distinct families of hybrids

    Article • Steroids, January 2011, Elsevier

    Professor Gervais Bérubé

  46. Synthesis of d- and l-tyrosine-chlorambucil analogs active against breast cancer cell lines

    Article • Bioorganic & Medicinal Chemistry Letters, December 2010, Elsevier

    Professor Gervais Bérubé

  47. Evaluation of in vivo biological activities of tetrapyrrole ethanolamides as novel anticancer agents

    Article • Journal of Photochemistry and Photobiology B Biology, July 2010, Elsevier

    Professor Gervais Bérubé

  48. First synthesis of separable isomeric testosterone dimers showing differential activities on prostate cancer cells

    Article • Bioorganic & Medicinal Chemistry Letters, April 2010, Elsevier

    Professor Gervais Bérubé

  49. Design, synthesis and biological evaluation of estradiol–chlorambucil hybrids as anticancer agents

    Article • Bioorganic & Medicinal Chemistry Letters, March 2010, Elsevier

    Professor Gervais Bérubé

  50. VP-128, a novel oestradiol-platinum(II) hybrid with selective anti-tumour activity towards hormone-dependent breast cancer cells in vivo

    Article • Endocrine Related Cancer, December 2009, Bioscientifica

    Professor Gervais Bérubé

  51. Functionalization of Testosterone at Position 7α and Synthesis of 7α-(3-Methoxypropyl)-4-androsten-17β-ol-3-one

    Article • Synthetic Communications, May 2009, Taylor & Francis

    Professor Gervais Bérubé

  52. Pure N-Alkylaminopropionic Acid and N-Alkylaminodipropionic Acid Sodium Salts: Synthesis, Characterization, and Physicochemical Properties

    Article • Journal of Surfactants and Detergents, April 2009, Wiley

    Professor Gervais Bérubé

  53. Errata

    Article • Synthetic Communications, April 2009, Taylor & Francis

    Professor Gervais Bérubé

  54. Simple and Efficient Synthesis of Steroidal Hybrids of Estrogen and Vitamin D3

    Article • Synthetic Communications, December 2008, Taylor & Francis

    Professor Gervais Bérubé

  55. Improved synthesis of unique estradiol-linked platinum(II) complexes showing potent cytocidal activity and affinity for the estrogen receptor alpha and beta

    Article • Steroids, October 2008, Elsevier

    Professor Gervais Bérubé

  56. Synthesis and cytotoxic activity of benzopyran-based platinum(II) complexes

    Article • Bioorganic & Medicinal Chemistry Letters, July 2008, Elsevier

    Professor Gervais Bérubé

  57. Transfer RNA Bindings to Antitumor Estradiol-Platinum(II) Hybrid and Cisplatin

    Article • DNA and Cell Biology, June 2008, Mary Ann Liebert Inc

    Professor Gervais Bérubé

  58. A novel series of potent cytotoxic agents targeting G2/M phase of the cell cycle and demonstrating cell killing by apoptosis in human breast cancer cells

    Article • Bioorganic & Medicinal Chemistry Letters, September 2007, Elsevier

    Professor Gervais Bérubé

  59. Synthesis and Preliminary Biological Evaluation of Estrone Dimers

    Article • Letters in Drug Design & Discovery, April 2007, Bentham Science Publishers

    Professor Gervais Bérubé

  60. Synthesis of Substituted Triarylpyran through an Unexpected Intramolecular Cyclization

    Article • Synthetic Communications, January 2007, Taylor & Francis

    Dr Atul Gupta, Professor Gervais Bérubé

  61. Natural and Synthetic Biologically Active Dimeric Molecules: Anticancer Agents, Anti-HIV Agents, Steroid Derivatives and Opioid Antagonists

    Article • Current Medicinal Chemistry, January 2006, Bentham Science Publishers

    Professor Gervais Bérubé

  62. Synthesis of 17β-estradiol-linked platinum(II) complexes and their cytocidal activity on estrogen-dependent and -independent breast tumor cells

    Article • Bioorganic Chemistry, February 2005, Elsevier

    Professor Gervais Bérubé

  63. A facile synthesis of C2-symmetric 17β-estradiol dimers

    Article • Bioorganic & Medicinal Chemistry Letters, February 2003, Elsevier

    Professor Gervais Bérubé

  64. Synthesis and Preliminary in Vitro Cytotoxic Activity of New Triphenylethylene Dimers

    Article • Bioorganic Chemistry, October 1999, Elsevier

    Professor Gervais Bérubé

  65. Ionic Characterization of a Synthetic Amphoteric Surfactant:  N,N-((Butyloxy)propyl)amino Diacetic Acid

    Article • Langmuir, August 1998, American Chemical Society (ACS)

    Professor Gervais Bérubé

  66. The synthesis and characterization of new triphenylethylene platinum(II) complexes

    Article • Inorganica Chimica Acta, October 1997, Elsevier

    Professor Gervais Bérubé

  67. Conjugation of doxorubicin to monoclonal anti-carcinoembryonic antigen antibody via novel thiol-directed cross-linking reagents

    Article • Bioorganic & Medicinal Chemistry, October 1995, Elsevier

    Professor Gervais Bérubé

  68. Synthesis and in vitro biological evaluation of new triphenylethylene platinum (II) complexes

    Article • Bioorganic & Medicinal Chemistry Letters, October 1995, Elsevier

    Professor Gervais Bérubé

  69. The synthesis of new platinum(II) complexes linked to non-steroidal estrogens

    Article • Inorganica Chimica Acta, July 1993, Elsevier

    Professor Gervais Bérubé

  70. Synthesis of New N-(Trifluoroacetyl) Doxorubicin Analogues

    Article • Synthetic Communications, April 1991, Taylor & Francis

    Professor Gervais Bérubé

  71. A stereocontrolled intramolecular cycloaddition – sigmatropic rearrangement approach to a tricyclo[7.4.01,6.01,10]tridecane precursor for (±) gascardic acid

    Article • Canadian Journal of Chemistry, January 1991, Canadian Science Publishing

    Professor Gervais Bérubé

  72. Synthesis and transannular Diels–Alder reaction of a 13-membered macrocyclic triene having a tetrasubstituted enol ether as dienophile

    Article • Canadian Journal of Chemistry, March 1990, Canadian Science Publishing

    Professor Gervais Bérubé

  73. An intramolecular cycloaddition-sigmatropic rearrangement approach to (±) gascardic acid

    Article • Tetrahedron Letters, January 1989, Elsevier

    Professor Gervais Bérubé

  74. Intramolecular Diels–Alder reactions of cyclopentadiene systems: Model studies for the total synthesis of the capnellenes

    Article • Canadian Journal of Chemistry, March 1988, Canadian Science Publishing

    Professor Gervais Bérubé

  75. Synthesis and transannular diels-alder reaction of a 13-membered macrocyclic triene having a tetrasubstituted enol ether as a dienophile

    Article • Tetrahedron Letters, January 1987, Elsevier

    Professor Gervais Bérubé

  76. 1,5-Acyclic stereoselection. The stereocontrolled synthesis of optically active vitamin E fourteen-carbon side chain alcohol

    Article • Canadian Journal of Chemistry, August 1984, Canadian Science Publishing

    Professor Gervais Bérubé

  77. Asymmetric induction on the Schiff bases

    Article • Tetrahedron Letters, January 1982, Elsevier

    Professor Gervais Bérubé