All Stories

  1. Structural characterization of antibiotic self-immunity tRNA synthetase in plant tumour biocontrol agent

    Article • Nature Communications, October 2016, Nature

    Dr Andrés Palencia

  2. Discovery of Novel Oral Protein Synthesis Inhibitors of Mycobacterium tuberculosis That Target Leucyl-tRNA Synthetase

    Article • Antimicrobial Agents and Chemotherapy, August 2016, ASM Journals

    Dr Andrés Palencia

  3. Crystal structure of hte Cryptosporidium muris cytosolic leucyl-tRNA synthetase editing domain complex with a post-transfer editing analogue of norvaline (Nv2AA)

    Article • August 2016, Protein Data Bank, Rutgers University

    Dr Andrés Palencia

  4. Crystal structure of the Cryptosporidium muris cytosolic leucyl-tRNA synthetase editing domain (apo structure)

    Article • August 2016, Protein Data Bank, Rutgers University

    Dr Andrés Palencia

  5. Crystal structure of the Cryptosporidium muris cytosolic leucyl-tRNA synthetase editing domain complex with the adduct AMP-AN6426

    Article • August 2016, Protein Data Bank, Rutgers University

    Dr Andrés Palencia

  6. Crystal structure of the Cryptosporidium muris cytosolic leucyl-tRNA synthetase editing domain complex with a post-transfer editing analogue of isoeucine (Ile2AA)

    Article • August 2016, Protein Data Bank, Rutgers University

    Dr Andrés Palencia

  7. Novel approach to fight toxoplasma and cryptosporidium

    Article • Antimicrobial Agents and Chemotherapy, July 2016, ASM Journals

    Dr Andrés Palencia

  8. Crystal structure of the P.falciparum cytosolic leucyl-tRNA synthetase editing domain (space group P1) containing deletions of insertions 1 and 3

    Article • June 2016, Protein Data Bank, Rutgers University

    Dr Andrés Palencia

  9. Crystal structure of the P.knowlesi cytosolic leucyl-tRNA synthetase editing domain

    Article • June 2016, Protein Data Bank, Rutgers University

    Dr Andrés Palencia

  10. Crystal structure of the P.falciparum cytosolic leucyl-tRNA synthetase editing domain (space group P21)

    Article • June 2016, Protein Data Bank, Rutgers University

    Dr Andrés Palencia

  11. Crystal structure of the P.falciparum cytosolic leucyl-tRNA synthetase editing domain (space group P1)

    Article • June 2016, Protein Data Bank, Rutgers University

    Dr Andrés Palencia

  12. Antimalarial Benzoxaboroles Target Plasmodium falciparum Leucyl-tRNA Synthetase

    Article • Antimicrobial Agents and Chemotherapy, June 2016, ASM Journals

    Dr Andrés Palencia

  13. Aminoacetylation Reaction Catalyzed by Leucyl-tRNA Synthetase Operates via a Self-Assisted Mechanism Using a Conserved Residue and the Aminoacyl Substrate

    Article • The Journal of Physical Chemistry, May 2016, American Chemical Society (ACS)

    Dr Andrés Palencia

  14. Crystal structure of the ternary complex of Agrobacterium radiobacter K84 agnB2 LeuRS-tRNA-LeuAMS

    Article • February 2016, Protein Data Bank, Rutgers University

    Dr Andrés Palencia

  15. Analysis of the Resistance Mechanism of a Benzoxaborole Inhibitor Reveals Insight into the Leucyl-tRNA Synthetase Editing Mechanism

    Article • ACS Chemical Biology, October 2015, American Chemical Society (ACS)

    Dr Andrés Palencia

  16. Crystal structure of the LeuRS editing domain of Candida albicans in complex with the adduct AN2690-AMP

    Article • July 2015, Protein Data Bank, Rutgers University

    Dr Andrés Palencia

  17. Crystal structure of the LeuRS editing domain of Candida albicans Mutant K510A

    Article • July 2015, Protein Data Bank, Rutgers University

    Dr Andrés Palencia

  18. Crystal structure of the LeuRS editing domain of Candida albicans Mutant K510A in complex with the adduct formed by AN2690-AMP

    Article • July 2015, Protein Data Bank, Rutgers University

    Dr Andrés Palencia

  19. Structure and dynamics of the MKK7–JNK signaling complex

    Article • Proceedings of the National Academy of Sciences, March 2015, Proceedings of the National Academy of Sciences

    Dr Andrés Palencia

  20. Crystal structure of the E.coli LeuRS-tRNA complex with the non- cognate isoleucyl adenylate analogue

    Article • July 2014, Protein Data Bank, Rutgers University

    Dr Andrés Palencia

  21. The physiological target for LeuRS translational quality control is norvaline

    Article • The EMBO Journal, June 2014, EMBO

    Dr Andrés Palencia

  22. Crystal structure of mouse mu‐crystallin complexed with NADPH and the T3 thyroid hormone

    Article • FEBS Journal, February 2014, Wiley

    Dr Andrés Palencia

  23. Crystal structure of Mycoplasma mobile Leucyl-tRNA Synthetase with Leu-AMS in the active site

    Article • February 2013, Protein Data Bank, Rutgers University

    Dr Andrés Palencia

  24. Leucyl-tRNA synthetase editing domain functions as a molecular rheostat to control codon ambiguity in Mycoplasma pathogens

    Article • Proceedings of the National Academy of Sciences, February 2013, Proceedings of the National Academy of Sciences

    Dr Andrés Palencia

  25. Ternary complex of E. coli leucyl-tRNA synthetase, tRNA(leu) and toxic moiety from agrocin 84 (TM84) in aminoacylation-like conformation

    Article • January 2013, Protein Data Bank, Rutgers University

    Dr Andrés Palencia

  26. Plant tumour biocontrol agent employs a tRNA-dependent mechanism to inhibit leucyl-tRNA synthetase

    Article • Nature Communications, January 2013, Nature

    Dr Andrés Palencia

  27. Discovery of a Novel Class of Boron-Based Antibacterials with Activity against Gram-Negative Bacteria

    Article • Antimicrobial Agents and Chemotherapy, January 2013, ASM Journals

    Dr Andrés Palencia

  28. Structure of extended Tudor domain TD3 from mouse TDRD1 in complex with MILI peptide containing dimethylarginine 45.

    Article • October 2012, Protein Data Bank, Rutgers University

    Dr Andrés Palencia

  29. Structure of extended Tudor domain TD3 from mouse TDRD1

    Article • October 2012, Protein Data Bank, Rutgers University

    Dr Andrés Palencia

  30. The multiple Tudor domain-containing protein TDRD1 is a molecular scaffold for mouse Piwi proteins and piRNA biogenesis factors

    Article • RNA, September 2012, Cold Spring Harbor Laboratory Press

    Dr Andrés Palencia

  31. A Role for Fkbp6 and the Chaperone Machinery in piRNA Amplification and Transposon Silencing

    Article • Molecular Cell, September 2012, Elsevier

    Dr Andrés Palencia

  32. Ternary complex of E. coli leucyl-tRNA synthetase, tRNA(leu) and leucyl-adenylate analogue in the aminoacylation conformation

    Article • June 2012, Protein Data Bank, Rutgers University

    Dr Andrés Palencia

  33. Ternary complex of E. coli leucyl-tRNA synthetase, tRNA(leu) and leucine in the editing conformation

    Article • June 2012, Protein Data Bank, Rutgers University

    Dr Andrés Palencia

  34. Ternary complex of E. coli leucyl-tRNA synthetase, tRNA(leu) and the benzoxaborole AN2679 in the editing conformation

    Article • June 2012, Protein Data Bank, Rutgers University

    Dr Andrés Palencia

  35. Ternary complex of E. coli leucyl-tRNA synthetase, tRNA(leu) and the benzoxaborole AN2679 in the editing conformation

    Article • June 2012, Protein Data Bank, Rutgers University

    Dr Andrés Palencia

  36. Structural dynamics of the aminoacylation and proofreading functional cycle of bacterial leucyl-tRNA synthetase

    Article • Nature Structural & Molecular Biology, June 2012, Nature

    Dr Andrés Palencia

  37. Mutational and Metal Binding Analysis of the Endonuclease Domain of the Influenza Virus Polymerase PA Subunit

    Article • Journal of Virology, June 2010, ASM Journals

    Dr Andrés Palencia

  38. Crystallization by capillary counter-diffusion and structure determination of the N114A mutant of the SH3 domain of Abl tyrosine kinase complexed with a high-affinity peptide ligand

    Article • Acta Crystallographica Section D Biological Crystallography, April 2007, International Union of Crystallography

    Dr. Jose A. Gavira, Ana Camara-Artigas, Dr Andrés Palencia

  39. Crystallographic structure of human Tsg101 UEV domain

    Article • March 2006, Protein Data Bank, Rutgers University

    Dr Andrés Palencia

  40. Structure of human TSG101 UEV domain

    Article • Acta Crystallographica Section D Biological Crystallography, March 2006, International Union of Crystallography

    Ana Camara-Artigas, Dr Andrés Palencia

  41. Thermodynamic Dissection of the Binding Energetics of Proline-rich Peptides to the Abl-SH3 Domain: Implications for Rational Ligand Design

    Article • Journal of Molecular Biology, February 2004, Elsevier

    Dr Andrés Palencia