All Stories

  1. Extracellular vesicles mediate stem cell signaling and systemic RNAi in planarians

    Article • Science Advances, February 2026, American Association for the Advancement of Science

    Dr Alejandro Sánchez Alvarado

  2. Metabolites produced by agat+ cells support regeneration in the planarian Schmidtea mediterranea

    Article • Developmental Biology, October 2025, Elsevier

    Dr Alejandro Sánchez Alvarado

  3. A powerful and versatile new fixation protocol for immunostaining and in situ hybridization that preserves delicate tissues

    Article • BMC Biology, November 2024, Springer Science + Business Media

    Dr Alejandro Sánchez Alvarado

  4. Chromatin remodeling protein BPTF regulates transcriptional stability in planarian stem cells

    Article • May 2024, Cold Spring Harbor Laboratory Press

    Dr Alejandro Sánchez Alvarado

  5. A PAK family kinase and the Hippo/Yorkie pathway modulate WNT signaling to functionally integrate body axes during regeneration

    Article • Proceedings of the National Academy of Sciences, May 2024, Proceedings of the National Academy of Sciences

    Dr Alejandro Sánchez Alvarado

  6. Developmental biology is poised to discover altogether new principles in biology in the 21st century

    Article • Developmental Biology, August 2022, Elsevier

    Dr Alejandro Sánchez Alvarado

  7. A PAK kinase family member and the Hippo/Yorkie pathway modulate WNT signaling to functionally integrate body axes during regeneration

    Article • July 2022, Cold Spring Harbor Laboratory Press

    Dr Alejandro Sánchez Alvarado

  8. Syrah, a Slide-seqV2 pipeline augmentation

    Article • March 2022, Cold Spring Harbor Laboratory Press

    Dr Alejandro Sánchez Alvarado

  9. Hox genes regulate asexual reproductive behavior and tissue segmentation in adult animals

    Article • Nature Communications, November 2021, Springer Science + Business Media

    Dr Alejandro Sánchez Alvarado

  10. The Diverse Manifestations of Regeneration and Why We Need to Study Them

    Article • Cold Spring Harbor Perspectives in Biology, November 2021, Cold Spring Harbor Laboratory Press

    Dr Alejandro Sánchez Alvarado

  11. A powerful and versatile new fixation protocol for immunohistology and in situ hybridization that preserves delicate tissues in planaria

    Article • November 2021, Cold Spring Harbor Laboratory Press

    Dr Alejandro Sánchez Alvarado

  12. Identification of rare, transient post-mitotic cell states that are induced by injury and required for whole-body regeneration in Schmidtea mediterranea

    Article • Nature Cell Biology, September 2021, Springer Science + Business Media

    Dr Alejandro Sánchez Alvarado

  13. Planarian Anatomy Ontology: a resource to connect data within and across experimental platforms

    Article • Development, August 2021, The Company of Biologists

    Dr Alejandro Sánchez Alvarado

  14. Image3C, a multimodal image-based and label-independent integrative method for single-cell analysis

    Article • eLife, July 2021, eLife

    Dr Alejandro Sánchez Alvarado

  15. Hoxgenes regulate asexual reproductive behavior and tissue segmentation in adult animals

    Article • January 2021, Cold Spring Harbor Laboratory Press

    Dr Alejandro Sánchez Alvarado

  16. Decellularization Enables Characterization and Functional Analysis of Extracellular Matrix in Planarian Regeneration

    Article • Molecular & Cellular Proteomics, January 2021, Elsevier

    Dr Alejandro Sánchez Alvarado

  17. Decellularization enables functional analysis of ECM remodeling in planarian regeneration

    Article • September 2020, Cold Spring Harbor Laboratory Press

    Dr Alejandro Sánchez Alvarado

  18. The Planarian Anatomy Ontology: A resource to connect data within and across experimental platforms

    Article • August 2020, Cold Spring Harbor Laboratory Press

    Dr Alejandro Sánchez Alvarado

  19. Molecular characterization of a flatworm Girardia isolate from Guanajuato, Mexico

    Article • July 2020, Cold Spring Harbor Laboratory Press

    Dr Alejandro Sánchez Alvarado

  20. Identification of rare transient somatic cell states induced by injury and required for whole-body regeneration

    Article • June 2020, Cold Spring Harbor Laboratory Press

    Dr Alejandro Sánchez Alvarado

  21. Subcellular analyses of planarian meiosis implicates a novel, double-membraned vesiculation process in nuclear envelope breakdown

    Article • May 2019, Cold Spring Harbor Laboratory Press

    Dr Alejandro Sánchez Alvarado

  22. Image3C: a multimodal image-based and label independent integrative method for single-cell analysis

    Article • April 2019, Cold Spring Harbor Laboratory Press

    Dr Alejandro Sánchez Alvarado

  23. Cultured pluripotent planarian stem cells retain potency and express proteins from exogenously introduced mRNAs

    Article • March 2019, Cold Spring Harbor Laboratory Press

    Dr Alejandro Sánchez Alvarado

  24. A nuclear hormone receptor and lipid metabolism axis are required for the maintenance and regeneration of reproductive organs

    Article • March 2018, Cold Spring Harbor Laboratory Press

    Dr Alejandro Sánchez Alvarado

  25. An adaptable chromosome preparation methodology for use in invertebrate research organisms

    Article • BMC Biology, February 2018, Springer Science + Business Media

    Dr Alejandro Sánchez Alvarado

  26. An adaptable chromosome preparation methodology for use in invertebrate research organisms

    Article • November 2017, Cold Spring Harbor Laboratory Press

    Dr Alejandro Sánchez Alvarado

  27. Cellular, ultrastructural and molecular analyses of epidermal cell development in the planarianSchmidtea mediterranea

    Article • August 2017, Cold Spring Harbor Laboratory Press

    Dr Alejandro Sánchez Alvarado

  28. Embryonic origin of adult stem cells required for tissue homeostasis and regeneration

    Article • eLife, January 2017, eLife

    Dr Alejandro Sánchez Alvarado

  29. Widespread maintenance of genome heterozygosity in Schmidtea mediterranea

    Article • Nature Ecology & Evolution, December 2016, Springer Science + Business Media

    Dr Alejandro Sánchez Alvarado

  30. Pathogenic shifts in endogenous microbiota impede tissue regeneration via distinct activation of TAK1/MKK/p38

    Article • eLife, July 2016, eLife

    Dr Alejandro Sánchez Alvarado

  31. Comparative and Transcriptome Analyses Uncover Key Aspects of Coding- and Long Noncoding RNAs in Flatworm Mitochondrial Genomes

    Article • G3 Genes Genomes Genetics, February 2016, Genetics Society of America

    Dr Alejandro Sánchez Alvarado

  32. Egr-5 is a post-mitotic regulator of planarian epidermal differentiation

    Article • eLife, October 2015, eLife

    Dr Alejandro Sánchez Alvarado

  33. SmedGD 2.0: TheSchmidtea mediterraneagenome database

    Article • genesis, July 2015, Wiley

    Dr Alejandro Sánchez Alvarado

  34. Stem cells and fluid flow drive cyst formation in an invertebrate excretory organ

    Article • eLife, June 2015, eLife

    Dr Alejandro Sánchez Alvarado

  35. Unravelling a can of worms

    Article • eLife, April 2015, eLife

    Dr Alejandro Sánchez Alvarado

  36. Synaptonemal complex extension from clustered telomeres mediates full-length chromosome pairing in Schmidtea mediterranea

    Article • Proceedings of the National Academy of Sciences, November 2014, Proceedings of the National Academy of Sciences

    Dr Alejandro Sánchez Alvarado

  37. Selective amputation of the pharynx identifies a FoxA-dependent regeneration program in planaria

    Article • eLife, April 2014, eLife

    Dr Alejandro Sánchez Alvarado

  38. Rethinking Differentiation: Stem Cells, Regeneration, and Plasticity

    Article • Cell, March 2014, Elsevier

    Dr Alejandro Sánchez Alvarado

  39. Molecular cloning and characterization of SL3: A stem cell-specific SL RNA from the planarian Schmidtea mediterranea

    Article • Gene, January 2014, Elsevier

    Dr Alejandro Sánchez Alvarado

  40. Histone Modifications and Regeneration in the Planarian Schmidtea mediterranea

    Article • January 2014, Elsevier

    Dr Alejandro Sánchez Alvarado

  41. Learning about loss

    Article • eLife, September 2013, eLife

    Dr Alejandro Sánchez Alvarado

  42. On the trail of a tropical disease

    Article • eLife, July 2013, eLife

    Dr Alejandro Sánchez Alvarado

  43. Cellular Hyperproliferation and Cancer as Evolutionary Variables

    Article • Current Biology, September 2012, Elsevier

    Dr Alejandro Sánchez Alvarado

  44. Planarian Immobilization, Partial Irradiation, and Tissue Transplantation

    Article • Journal of Visualized Experiments, August 2012, MyJove Corporation

    Dr Alejandro Sánchez Alvarado

  45. The history and enduring contributions of planarians to the study of animal regeneration

    Article • Wiley Interdisciplinary Reviews Developmental Biology, July 2012, Wiley

    Dr Alejandro Sánchez Alvarado

  46. TORC1 is required to balance cell proliferation and cell death in planarians

    Article • Developmental Biology, May 2012, Elsevier

    Dr Alejandro Sánchez Alvarado

  47. Q&A: What is regeneration, and why look to planarians for answers?

    Article • BMC Biology, January 2012, Springer Science + Business Media

    Dr Alejandro Sánchez Alvarado

  48. Expression of secreted Wnt pathway components reveals unexpected complexity of the planarian amputation response

    Article • Developmental Biology, November 2010, Elsevier

    Dr Alejandro Sánchez Alvarado

  49. Cell death and tissue remodeling in planarian regeneration

    Article • Developmental Biology, February 2010, Elsevier

    Dr Alejandro Sánchez Alvarado

  50. S19-01 Planarians, stem cells, and regeneration

    Article • Mechanisms of Development, August 2009, Elsevier

    Dr Alejandro Sánchez Alvarado

  51. High-resolution profiling and discovery of planarian small RNAs

    Article • Proceedings of the National Academy of Sciences, July 2009, Proceedings of the National Academy of Sciences

    Dr Alejandro Sánchez Alvarado

  52. A cellular view of regeneration

    Article • Nature, July 2009, Springer Science + Business Media

    Dr Alejandro Sánchez Alvarado

  53. Dynamic expression of planarian Wnt genes reveals complex response to amputation

    Article • Developmental Biology, July 2009, Elsevier

    Dr Alejandro Sánchez Alvarado

  54. Flow cytometry methods for the study of cell-cycle parameters of planarian stem cells

    Article • Developmental Dynamics, May 2009, Wiley

    Dr Alejandro Sánchez Alvarado

  55. Formaldehyde-based whole-mount in situ hybridization method for planarians

    Article • Developmental Dynamics, January 2009, Wiley

    Dr Alejandro Sánchez Alvarado

  56. The Shredding of a Caricature

    Article • Cell, December 2008, Elsevier

    Dr Alejandro Sánchez Alvarado

  57. Gene nomenclature guidelines for the planarianSchmidtea mediterranea

    Article • Developmental Dynamics, November 2008, Wiley

    Dr Alejandro Sánchez Alvarado

  58. Molecular Analysis of Stem Cells and Their Descendants during Cell Turnover and Regeneration in the Planarian Schmidtea mediterranea

    Article • Cell Stem Cell, September 2008, Elsevier

    Dr Alejandro Sánchez Alvarado

  59. Stem Cells: Time to Check Our Premises

    Article • Cell Stem Cell, July 2008, Elsevier

    Dr Alejandro Sánchez Alvarado

  60. Slicing across Kingdoms: Regeneration in Plants and Animals

    Article • Cell, February 2008, Elsevier

    Dr Alejandro Sánchez Alvarado

  61. Stem cells in animal models of regeneration

    Article • StemBook, January 2008, Stem Book

    Dr Alejandro Sánchez Alvarado

  62. Cell Turnover and Adult Tissue Homeostasis: From Humans to Planarians

    Article • Annual Review of Genetics, December 2007, Annual Reviews

    Dr Alejandro Sánchez Alvarado

  63. Stem cells and the Planarian Schmidtea mediterranea

    Article • Comptes Rendus Biologies, June 2007, Elsevier

    Dr Alejandro Sánchez Alvarado

  64. Bridging the regeneration gap: genetic insights from diverse animal models

    Article • Nature Reviews Genetics, November 2006, Springer Science + Business Media

    Dr Alejandro Sánchez Alvarado

  65. Design, Implementation and Deployment of a Commodity Cluster for Periodic Comparisons of Gene Sequences

    Article • January 2006, Wiley

    Dr Alejandro Sánchez Alvarado

  66. Planarian Regeneration: Its End Is Its Beginning

    Article • Cell, January 2006, Elsevier

    Dr Alejandro Sánchez Alvarado

  67. Multicellularity, stem cells, and the neoblasts of the planarian Schmidtea mediterranea

    Article • Experimental Cell Research, June 2005, Elsevier

    Dr Alejandro Sánchez Alvarado

  68. Identification of Genes Needed for Regeneration, Stem Cell Function, and Tissue Homeostasis by Systematic Gene Perturbation in Planaria

    Article • Developmental Cell, May 2005, Elsevier

    Dr Alejandro Sánchez Alvarado

  69. FUNDAMENTALS OF PLANARIAN REGENERATION

    Article • Annual Review of Cell and Developmental Biology, November 2004, Annual Reviews

    Dr Alejandro Sánchez Alvarado

  70. Planarians

    Article • Current Biology, September 2004, Elsevier

    Dr Alejandro Sánchez Alvarado

  71. Morphological and Functional Recovery of the Planarian Photosensing System during Head Regeneration

    Article • ZOOLOGICAL SCIENCE, March 2004, Zoological Society of Japan

    Dr Alejandro Sánchez Alvarado

  72. FGFR-related gene nou-darake restricts brain tissues to the head region of planarians

    Article • Nature, October 2002, Springer Science + Business Media

    Dr Alejandro Sánchez Alvarado

  73. Not your father's planarian: a classic model enters the era of functional genomics

    Article • Nature Reviews Genetics, March 2002, Springer Science + Business Media

    Professor Phillip Allan Newmark, Dr Alejandro Sánchez Alvarado

  74. Regeneration in the metazoans: why does it happen?

    Article • BioEssays, May 2000, Wiley

    Dr Alejandro Sánchez Alvarado

  75. Bromodeoxyuridine Specifically Labels the Regenerative Stem Cells of Planarians

    Article • Developmental Biology, April 2000, Elsevier

    Professor Phillip Allan Newmark, Dr Alejandro Sánchez Alvarado

  76. The use of planarians to dissect the molecular basis of metazoan regeneration

    Article • Wound Repair and Regeneration, July 1998, Wiley

    Professor Phillip Allan Newmark, Dr Alejandro Sánchez Alvarado