What is it about?
Urinary titin could serve as a novel, noninvasive biomarker to identify individuals with T2DM at high risk for muscle damage and sarcopenia, supporting early intervention and prevention strategies.
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Why is it important?
This study is the world's first to demonstrate that a simple, non-invasive urine test can detect signs of muscle weakness in individuals with diabetes years in advance.
Perspectives
By utilizing urinary titin measurement, personalized prevention and treatment approaches, such as nutrition and exercise guidance are expected to contribute to preventing the need for long-term care and extending healthy life expectancy in people with diabetes.
Michio Shimabukuro
Fukushima Medical University
Read the Original
This page is a summary of: Prediction of Sarcopenia Onset in Type 2 Diabetes Using Urinary Titin Levels: A Japanese Prospective Cohort Study, Diabetes Care, August 2025, American Diabetes Association,
DOI: 10.2337/dc25-1067.
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