Serum Galectin-3 and Subsequent Risk of Coronary Heart Disease in Subjects With Childhood-Onset Type 1 Diabetes: A Cohort Study

What is it about?

This nationwide cohort study includes 295 cases with childhood-onset type 1 diabetes with maximum diabetes duration of 45 years and a maximum follow-up time from baseline (2002-2003) of 16 years. We investigated selected biomarkers in stored blood samples taken during clinical examinations in 2002-2003 to study any association with future event of coronary heart disease (CHD). The aim of this study was to investigate whether selected biomarkers, reflecting inflammation, fibrosis and myocardial injury are associated with risk of CHD in persons with long-standing childhood-onset type 1 diabetes.We found significant association of galectin-3 and future risk of developing CHD, after adjusting for conventional risk factors.

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