Reduced function of the adaptor SH2B3 promotes T1D via altered cytokine-regulated, T cell intrinsic immune tolerance

What is it about?

Specific genetic variation in a gene called SH2B3 increases the risk of developing type 1 diabetes in humans. SH2B3 normally acts as a "brake" on the immune system, particularly on T cells (a type of immune cell) and reduced function mutations promote autoimmune destruction of the pancreas in mouse models of diabetes.

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