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Mutations in the insulin gene can lead to rare forms of diabetes. We discovered a new mouse model of diabetes with such an insulin mutation. It is thought some of the mechanisms leading to diabetes development in these mice may have some similarities to other more common types of diabetes. It is hoped that in the future this mouse could be used to understand more about how diabetes develops.
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This page is a summary of: The KINGS Ins2+/G32S Mouse: A Novel Model of β-Cell Endoplasmic Reticulum Stress and Human Diabetes, Diabetes, September 2020, American Diabetes Association,
DOI: 10.2337/db20-0570.
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