Anti-Insulin Receptor Antibodies Improve Hyperglycemia in a Mouse Model of Human Insulin Receptoropathy

What is it about?

Antibodies that stick to the insulin receptor can bypass some disease-causing genetic alteration in the receptor in studies of cells. It is now shown that they can also be beneficial in mice mimicking human receptor defects in the liver. The benefit is blunted by reduced levels of receptor. These findings suggest a route to developing a novel type of targeted treatment for some patients with extreme insulin resistance, especially if the problem of reduced receptor levels can be overcome.

Featured Image