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Dopamine is a signaling molecule as a brake to negatively regulate insulin secretion. Dopamine is stored in the vesicle and is co-secreted with insulin. Storage of dopamine in the vesicle is important to protect beta-cells from prolonged exposure to ROS. that generated during insulin secretion, particularly during overnutrition.
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This page is a summary of: VMAT2 Safeguards β-Cells Against Dopamine Cytotoxicity Under High-Fat Diet–Induced Stress, Diabetes, August 2020, American Diabetes Association,
DOI: 10.2337/db20-0207.
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