What is it about?
We have executed an unbiased screen to find drug-like molecules that protect insulin-secreting beta cells from stress. Molecules we found worked by reducing calcium overload in the beta cells.
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Why is it important?
The study adds a central hypothesis around a causal role for calcium overload for beta-cell dysfunction in Type 2 Diabetes and suggests calcium antagonists as possible therapeutics.
Perspectives
I hope that this work will lead to the T2D community to further consider the role of calcium antagonists in diabetes.
Alina Berdichevsky
Novartis AG
Read the Original
This page is a summary of: A Phenotypic Screen Identifies Calcium Overload as a Key Mechanism of β-Cell Glucolipotoxicity, Diabetes, February 2020, American Diabetes Association,
DOI: 10.2337/db19-0813.
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