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We observed that individuals with mental disorders in young adulthood had an increased long-term risk of cardiometabolic complications 40 years later, but that much of this was attributable to general liability toward psychopathology rather than to specific psychiatric conditions. Familial co-aggregation analyses suggested that the elevated risk did not appear attributable to unmeasured confounds shared by siblings.This highlights the importance of transdiagnostic interventions to reduce the risk of cardiometabolic complications, particularly in patients with several mental disorders.

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This page is a summary of: Associations Between General and Specific Mental Health Conditions in Young Adulthood and Cardiometabolic Complications in Middle Adulthood: A 40-Year Longitudinal Familial Coaggregation Study of 672,823 Swedish Individuals, American Journal of Psychiatry, January 2024, American Psychiatric Association,
DOI: 10.1176/appi.ajp.20220951.
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