Diagnosis- and Cell Type-Specific Mitochondrial Functional Pathway Signatures in Schizophrenia and Bipolar Disorder

What is it about?

The shared risk factors and clinical features in schizophrenia and bipolar disorder may be linked via mitochondrial dysfunction. This study investigated whether mitochondrial-related gene expression and higher-order gene co-expression relationships differ in both disorders in cortex and specific neuronal populations. Schizophrenia and bipolar disorder do not appear to share similar mitochondrial-related alterations. The selective and coordinated down-regulation of energy production genes in schizophrenia is consistent with the effects of chronic reductions in pyramidal neuron firing. Enhancement of this activity may serve as a therapeutic target.

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