What is it about?
Melanoma cancer diagnosed in the lung of a woman, including Caris molecular testing showing mutations. Treatment included surgery and immunotherapy regimens.
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Why is it important?
Molecular characterization of melanoma presenting as a lung primary is rare in the literature. This case report documents extensive molecular testing, histological staining, and pathology review, in addition to thorough physical exam, PET/CT testing, and patient history methodology, in order to aid in characterization/differentiation of melanoma as lung primary or metastasis. Surgery, coupled with recent advances in immunotherapeutic drug combinations may further advance treatment options for lung melanoma patients and increase overall survival or limit progression of disease.
Perspectives
Molecular mutations in conjunction with histopathology and thorough patient history may help physicians differentiate between primary or metastatic melanoma lesions in the lung. Patient treatment with surgical intervention and immunotherapy drug combinations may lead to improvement in patient outcomes.
Layla Landgraf
Cleveland Clinic Indian River Hospital
Read the Original
This page is a summary of: Primary Melanoma of the Lung Treated with Surgery, Dabrafenib and Trametinib, Case Reports in Oncology, July 2020, Karger Publishers,
DOI: 10.1159/000508093.
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