What is it about?
Malaria is endemeic in about 100 countries in the world and resistances of Plasmodium parasites to existing treatments is an issue. The paarsite subtilisin-like protease 1 plays an essentail role for the parasite to egress from human hepatic and erytthrocytic cells and emerged as an interesting drug-target to design new generation of anti-malarial candidates. In this issue, we describe the first 3D-structure of Sub1 in complex with a specific inhibitor.
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Why is it important?
Informations provided by these structural data will help cehemists to design and synthetise optimized Sub1 inhibitor that could eventually become new lead compounds to figth malaria.
Read the Original
This page is a summary of: 3D structures of the Plasmodium vivax subtilisin-like drug target SUB1 reveal conformational changes to accommodate a substrate-derived α-ketoamide inhibitor, Acta Crystallographica Section D Structural Biology, July 2023, International Union of Crystallography,
DOI: 10.1107/s2059798323004710.
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