What is it about?
A long-standing question about G protein-coupled receptors (GPCRs) is whether they function as dimers or monomers. This paper describes what possible GPCR dimers are seen in the large number of crystal structures obtained to date. The portions of the proteins involved in inter-protein interactions are identified.
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Why is it important?
This paper provides a catalog of how GPCRs might interact in their membrane environments.
Perspectives
Several structures of GPCRs bound as monomers to the G proteins are now available, so further research is needed to prove the existence of GPCR dimers. The results in this paper provide a starting point for considering the types of dimers that might be found.
Ronald Stenkamp
University of Washington System
Read the Original
This page is a summary of: Identifying G protein-coupled receptor dimers from crystal packings, Acta Crystallographica Section D Structural Biology, June 2018, International Union of Crystallography,
DOI: 10.1107/s2059798318008136.
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