What is it about?
One of the few examples of an eight memebered ring resulting from aldol condensation, showing the crystal structure and interactions within the crystalline lattice with co-crystallized acetonitrile molecules
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Why is it important?
1,3-Indandione and related structures have been used for aldol condensation for many years, especially condensed cyclization products, some of which have been used as antiemetic and anticancer drugs.
Perspectives
This article shows an example of a crystal structure which contains many interesting features: An eight membered ring, five different aromatic "arms" stemming from the central ring, pi-pi interactions between these arms within the crystal lattice and further interactions with solvent molecules, including a hydrogen bonding network. This structure has pretty much any intermolecular interaction possible, with the except of halogen bonds.
mark baranov
Ben-Gurion University of the Negev
Read the Original
This page is a summary of: Crystal structure determination of rac-11′-(1-acetyl-1H-indazol-3-yl)-11′,11a′-dihydro-10′H,17′H-spiro[indene-2,18′-[5a,16b]methanotriindeno[1,2-b:1′,2′-d:2′′,1′′-g]oxocine]-1,3,10′,12′,17′..., Acta Crystallographica Section E Crystallographic Communications, September 2018, International Union of Crystallography,
DOI: 10.1107/s2056989018011763.
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